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DR2313 | PARP inhibitor

DR2313 | PARP inhibitor Structure
DR2313 | PARP inhibitor structure
CAS No.
284028-90-6
Chemical Name:
DR2313 | PARP inhibitor
Synonyms
DR 2313;IR 2313;SC-202756;DR2313 >=98% (HPLC);PARP Inhibitor XI, DR2313;4H-Thiopyrano[4,3-d]pyriMidin-4-one,3,5,7,8-tetrahydro-2;DR2313 (PARP Inhibitor XI), brain-penetrant PARP inhibitor;7,8-Dihydro-2-methyl-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one;3,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one;1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE
CBNumber:
CB9837735
Molecular Formula:
C8H10N2OS
Molecular Weight:
182.24
MDL Number:
MFCD08703132
MOL File:
284028-90-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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DR2313 | PARP inhibitor Properties

Boiling point 349.3±52.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility H2O: >2mg/mL (warmed)
form powder
pka 1.54±0.20(Predicted)
color white to beige
Water Solubility H2O: >2mg/mL (warmed)
InChI 1S/C8H10N2OS/c1-5-9-7-2-3-12-4-6(7)8(11)10-5/h2-4H2,1H3,(H,9,10,11)
InChIKey HRYKZAKEAVZGJD-UHFFFAOYSA-N
SMILES CC1=NC(=O)C2=C(CCSC2)N1
FDA UNII 4GM3843TP6
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

DR2313 | PARP inhibitor price More Price(42)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0397 DR2313 ≥98% (HPLC) 284028-90-6 5mg $62.4 2026-04-30 Buy
Sigma-Aldrich SML0397 DR2313 ≥98% (HPLC) 284028-90-6 25mg $337 2022-05-15 Buy
Cayman Chemical 21181 DR2313 ≥98% 284028-90-6 1mg $36 2026-04-30 Buy
Cayman Chemical 21181 DR2313 ≥98% 284028-90-6 5mg $82 2026-04-30 Buy
Cayman Chemical 21181 DR2313 ≥98% 284028-90-6 10mg $135 2026-04-30 Buy
Product number Packaging Price Buy
SML0397 5mg $62.4 Buy
SML0397 25mg $337 Buy
21181 1mg $36 Buy
21181 5mg $82 Buy
21181 10mg $135 Buy

DR2313 | PARP inhibitor Chemical Properties, Uses, Production

Uses

DR2313 is a potent, selective, competitive and brain-penetrant inhibitor of poly(ADP-ribose) polymerase (PARP), with IC50s of 0.20 μM and 0.24 μM for PARP-1 and PARP-2, respectively. DR2313 exhibits neuroprotective effects on ischemic injuries in vitro and in vivo[1][2].

Biological Activity

Potent, competitive inhibitor of poly(ADP-ribose) polymerase (PARP) (IC 50 values are 0.20 and 0.24 μ M for PARP-1 and PARP-2 respectively). Neuroprotective; reduces neuronal cell death in models of cerebral ischemia in vivo and in vitro . Brain penetrant.

in vivo

DR2313 (3-10 mg/kg i.v. bolus or infusion for 6 h) significantly reduces the cortical infarct volume in both permanent and transient focal ischemia models in rats[1].

Animal Model:Male Wistar rats (220-300 g) with permanent MCA occlusions (pMCAos) and transient MCA occlusions (tMCAos)[1]
Dosage:3, 10 mg/kg
Administration:I.v. bolus and i.v. infusion for 6 h beginning 5 min before the onset of ischemia
Result:Reduced the infarct volume in a dose-dependent manner in pMCAo and tMCAo model.

IC 50

PARP-1: 0.20 μM (IC50); PARP-2: 0.24 μM (IC50)

References

[1] Nakajima H, et, al. A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats. J Pharmacol Exp Ther. 2005 Feb;312(2):472-81. DOI:10.1124/jpet.104.075465
[2] Xu Z, et, al. Endonuclease G does not play an obligatory role in poly(ADP-ribose) polymerase-dependent cell death after transient focal cerebral ischemia. Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299(1):R215-21. DOI:10.1152/ajpregu.00747.2009

DR2313 | PARP inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

DR2313 | PARP inhibitor Suppliers

Global Suppliers ( 129)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
EnciPharmatech Co., Ltd 025-52714267-66 13813902930 stephen_shengll@hotmail.com China 231 64
China Langchem Inc. 0086-21-58956006 China 7798 57
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2774 58
Shanghai YuLue Chemical Co., Ltd. 021-60345187 13671753212 lzz841106@aliyun.com China 10244 55
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Shanghai Longsheng chemical Co.,Ltd. 59
EnciPharmatech Co., Ltd 64
China Langchem Inc. 57
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
AdooQ BioScience, LLC 58
Shanghai YuLue Chemical Co., Ltd. 55
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from DR2313 | PARP inhibitor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DR2313 pictures 2026-07-27 DR2313
284028-90-6
 $29.00-98.00 99.84% 10g TargetMol Chemicals Inc.
1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE pictures 2026-06-30 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE
284028-90-6
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE pictures 2020-01-01 1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE
284028-90-6
 $1.00 1KG 95-99% 1ton Career Henan Chemical Co
  • DR2313 pictures
  • DR2313
    284028-90-6
  • $29.00-98.00
  • 99.84%
  • TargetMol Chemicals Inc.

DR2313 | PARP inhibitor Spectrum

1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE(284028-90-6)1HNMR

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1of4

1,5,7,8-TETRAHYDRO-2-METHYL-4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE DR 2313 7,8-Dihydro-2-methyl-1H-thiopyrano[4,3-d]pyrimidin-4(5H)-one 3,5,7,8-Tetrahydro-2-methyl-4H-thiopyrano[4,3-d]pyrimidin-4-one 4H-Thiopyrano[4,3-d]pyriMidin-4-one,3,5,7,8-tetrahydro-2 4H-THIOPYRANO[4,3-D]PYRIMIDIN-4-ONE,3,5,7,8-TETRAHYDRO-2-METHYL- SC-202756 2-Methyl-1-sulfanyl-1H,4H,5H,7H,8H-pyrano[4,3-d]pyriMidin-4-one PARP Inhibitor XI, DR2313 IR 2313 3,5,7,8-tetrahydro-2-methyl-4h-thiopyrano(4,3-d)pyrimidin-4-one, 98%(HPLC) DR2313 >=98% (HPLC) DR2313 (PARP Inhibitor XI), brain-penetrant PARP inhibitor 284028-90-6