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ChemicalBook >> CAS DataBase List >>1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro-

1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro-

1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- Structure
1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- structure
CAS No.
1186608-83-2
Chemical Name:
1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro-
Synonyms
SW-75;SWF-75;3-BroMo-5-nitro-1H-pyrazo...;3-Bromo-5-nitropyrazolo[3,4-b]pyridine;3-bromo-5-nitro-2H-pyrazolo[3,4-b]pyridine;3-BroMo-5-nitro-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro-
CBNumber:
CB42552820
Molecular Formula:
C6H3BrN4O2
Molecular Weight:
243.02
MDL Number:
MFCD13193610
MOL File:
1186608-83-2.mol
MSDS File:
SDS
Last updated:2026-05-28 02:46:18
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1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- Properties

storage temp. under inert gas (nitrogen or Argon) at 2-8°C
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405

1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- price More Price(22)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 112939 3-Bromo-5-nitro-1H-pyrazolo[3,4-b]pyridine 1186608-83-2 250.00mg $22 2026-05-18 Buy
Matrix Scientific 112939 3-Bromo-5-nitro-1H-pyrazolo[3,4-b]pyridine 1186608-83-2 1.00g $79 2026-05-18 Buy
Matrix Scientific 112939 3-Bromo-5-nitro-1H-pyrazolo[3,4-b]pyridine 1186608-83-2 5.00g $349 2026-05-18 Buy
Synthonix B7961 3-Bromo-5-nitro-1H-pyrazolo[3,4-b]pyridine 97.0% 1186608-83-2 1g $90 2026-05-06 Buy
Synthonix B7961 3-Bromo-5-nitro-1H-pyrazolo[3,4-b]pyridine 97.0% 1186608-83-2 5g $400 2026-05-06 Buy
Product number Packaging Price Buy
112939 250.00mg $22 Buy
112939 1.00g $79 Buy
112939 5.00g $349 Buy
B7961 1g $90 Buy
B7961 5g $400 Buy

1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- Chemical Properties, Uses, Production

Synthesis

5-Nitro-1H-pyrazolo[3,4-b]pyridine

63572-73-6

1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro-

1186608-83-2

The general procedure for the synthesis of 3-bromo-5-nitro-1H-pyrazolo[3,4-b]pyridine from 5-nitro-7-azaindazole was as follows: a 4N NaOH solution (5.12 mL, 20.5 mmol) was slowly added to a dioxane (30 mL) solution of 5-nitro-1H-pyrazolo[3,4-b]pyridine (0.84 g, 5.12 mmol) at 0 °C. ) solution, followed by dropwise addition of bromine (1.05 mL, 20.5 mmol). After removal of the ice bath, the reaction mixture was stirred at room temperature for 30 min. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (100 mL) and the reaction was quenched with saturated aqueous Na2S2O3 solution (50 mL). The aqueous layer was further extracted with ethyl acetate (100 mL). The organic layers were combined, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using hexane/ethyl acetate (9:1, v/v) as eluent to afford 3-bromo-5-nitro-1H-pyrazolo[3,4-b]pyridine (1.10 g, 88% yield) as solid.

References

[1] Patent: WO2011/25968, 2011, A1. Location in patent: Page/Page column 49
[2] Patent: WO2009/111279, 2009, A1. Location in patent: Page/Page column 96
[3] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 5, p. 342 - 347

1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- Preparation Products And Raw materials

Raw materials

5-Nitro-1H-pyrazolo[3,4-b]pyridine Sodium thiosulfate Sodium hydroxide Water 1,4-Dioxane

Preparation Products

1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- Suppliers

Global Suppliers ( 58)
Supplier Tel Email Country ProdList Advantage
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
ZEROSCHEM.CO.,LTD. 10-61256048 13810278579; sales@zeroschem.com China 1400 59
Wuhan ariel chemical Co., LTD. 18986259541 18986259541 sales@3stc.com China 3828 58
SynAsst Chemical. 021-60343070 China 12731 55
Wuhan Kaymke Chemical Co., Ltd., 027-87342388 18086026008 sales@kaymke.com China 3537 55
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512 China 1784 58
Nanjing ShengSai Chemical Co., Ltd. 025-85205967 13951876367 shengsaichem@163.com China 818 58
Nantong MYBio-pharm. Co., Ltd. 0513-85921823 18662920231 sales@ntminyanmedical.com China 4563 58
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
Shanghai Kahn Pharmaceutical Co., Ltd. 021-34979681; 17701870669 41513101@qq.com China 1788 55
Supplier Advantage
Pure Chemistry Scientific Inc. 62
ZEROSCHEM.CO.,LTD. 59
Wuhan ariel chemical Co., LTD. 58
SynAsst Chemical. 55
Wuhan Kaymke Chemical Co., Ltd., 55
CEG Chemical Science&Technology Co., Ltd. 58
Nanjing ShengSai Chemical Co., Ltd. 58
Nantong MYBio-pharm. Co., Ltd. 58
ShangHai KenEn Chemical Technology Co., Ltd. 55
Shanghai Kahn Pharmaceutical Co., Ltd. 55

1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- Spectrum

3-BroMo-5-nitro-1H-pyrazo...(1186608-83-2)1HNMR

1186608-83-2 (1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro-) Related Search:

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Acetic acid, [(5-chloro-2-pyridinyl)aMino]oxo- 4-Chloro-5-fluoro-2-(Meth... 1-Benzylazetidin-3-ol tert-butyl 7-oxo-2,6-diazaspiro[3.4]octane-2-carboxylate DL-7-Azatryptophan Monohydrate
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester 4-Chloro-7-azaindole 4-Bromo-7-azaindole 6-Bromo-4-indolecarboxylic acid methyl ester
1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID 4-Chloro-5H-pyrrolo[3,2-d] pyrimidine 1H-Pyrrolo[2,3-b]pyridin-5-ol

1of4

3-BroMo-5-nitro-1H-pyrazolo[3,4-b]pyridine 3-bromo-5-nitro-2H-pyrazolo[3,4-b]pyridine 1H-Pyrazolo[3,4-b]pyridine, 3-bromo-5-nitro- SWF-75 SW-75 3-Bromo-5-nitropyrazolo[3,4-b]pyridine 3-BroMo-5-nitro-1H-pyrazo... 1186608-83-2