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1H-PYRROLO[2,3-B]PYRIDIN-5-OL

1H-PYRROLO[2,3-B]PYRIDIN-5-OL structure

CAS No.: 98549-88-3

Chemical Name:: 1H-PYRROLO[2,3-B]PYRIDIN-5-OL

Synonyms: 5-HYDROXY-7-AZAINDOLE;SW-63;SWF-63;5-Hydroxyazaindole;Vinetola impurity 12;5-Hydroxy-7-azaindole 97%;H-PYRROLO[2,3-B]PYRIDIN-5-OL;1H-Pyrrolo[2,3-B]Pridin-5-ol;1H-PYRROLO[2,3-B]PYRIDIN-5-OL;5-hydroxypyrrolo[2,3-b]pyridine

CBNumber:: CB3484584

Molecular Formula:: C7H6N2O

Molecular Weight:: 134.14

MDL Number:: MFCD08272242

MOL File:: 98549-88-3.mol

MSDS File:: SDS

Last updated:2026-05-12 09:14:19

Product description	Number	Pack Size	Price
1H-Pyrrolo[2,3-b]pyridin-5-ol Aldrich	ADE000886	1g	$870
1H-pyrrolo[2,3-b]pyridin-5-ol 97.0%	P9657	1g	$16
1H-pyrrolo[2,3-b]pyridin-5-ol 97.0%	P9657	5g	$30
1H-pyrrolo[2,3-b]pyridin-5-ol 97.0%	P9657	10g	$60
1H-pyrrolo[2,3-b]pyridin-5-ol 97.0%	P9657	25g	$150
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1H-PYRROLO[2,3-B]PYRIDIN-5-OL Properties

Melting point	219-220°C
Boiling point	381.8±42.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	6.93±0.20(Predicted)
form	Powder
Appearance	Light brown to light yellow Solid
InChI	InChI=1S/C7H6N2O/c10-6-3-5-1-2-8-7(5)9-4-6/h1-4,10H,(H,8,9)
InChIKey	VUQZKLXKFUBWRP-UHFFFAOYSA-N
SMILES	C12NC=CC1=CC(O)=CN=2
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xi,Xn
Risk Statements	22
Safety Statements	24/25
WGK Germany	3
HazardClass	IRRITANT
HS Code	29339900
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral
REACH Registrations	Active

1H-PYRROLO[2,3-B]PYRIDIN-5-OL price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	ADE000886	1H-Pyrrolo[2,3-b]pyridin-5-ol Aldrich	98549-88-3	1g	$870	2026-04-30	Buy
Synthonix	P9657	1H-pyrrolo[2,3-b]pyridin-5-ol 97.0%	98549-88-3	1g	$16	2026-05-06	Buy
Synthonix	P9657	1H-pyrrolo[2,3-b]pyridin-5-ol 97.0%	98549-88-3	5g	$30	2026-05-06	Buy
Synthonix	P9657	1H-pyrrolo[2,3-b]pyridin-5-ol 97.0%	98549-88-3	10g	$60	2026-05-06	Buy
Synthonix	P9657	1H-pyrrolo[2,3-b]pyridin-5-ol 97.0%	98549-88-3	25g	$150	2026-05-06	Buy

Product number	Packaging	Price	Buy
ADE000886	1g	$870	Buy
P9657	1g	$16	Buy
P9657	5g	$30	Buy
P9657	10g	$60	Buy
P9657	25g	$150	Buy

1H-PYRROLO[2,3-B]PYRIDIN-5-OL Chemical Properties,Uses,Production

Chemical Properties

Light yellow solid

Uses

1H-Pyrrolo[2,3-b]pyridin-5-ol is a reagent used in the synthesis of potent VEGFR-2 inhibitors. 7-Azaindole derivative identified as an intermediate in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets.

Synthesis

5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE

858116-66-2

98549-88-3

General procedure for the synthesis of 1H-pyrrolo[2,3-b]pyridin-5-ol from 1-triisopropylsilyl-5-bromo-7-azaindole: To a 50 mL reaction flask at room temperature were added the compound of formula II (4.08 g, 11.5 mmol), copper acetylacetonate (0.15 g, 0.575 mmol), MHPO (0.15 g, 0.575 mmol), lithium hydroxide monohydrate (2.42 g, 57.5 mmol), 18 mL of DMSO, and 4.5 mL of water. Stirring was turned on, the air in the reaction system was replaced with nitrogen, and the reaction temperature was raised to an internal temperature of 100°C. The reaction was maintained at this temperature for 6 h. The reaction was carried out by TLC. The progress of the reaction was monitored by TLC and after confirming that the ingredients were fully reacted, the heating was stopped and the reaction mixture was cooled to room temperature (20-30°C). 100 mL of water was added to the reaction mixture and the pH was adjusted to 6 with 2 N dilute hydrochloric acid, at which point a solid precipitated. Filtering was carried out and the solid was collected. The aqueous phase was extracted with ethyl acetate (50 mL × 3) and the organic phases were combined. The organic phase was washed sequentially with water and saturated aqueous sodium chloride solution each, and then dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure to give the compound of formula III. Yield: 1.2 g, yield: 78.5%.

References

[1] Patent: CN107434807, 2017, A. Location in patent: Paragraph 0056-0059; 0080-0083; 0102-0106

1H-PYRROLO[2,3-B]PYRIDIN-5-OL synthesis

Synthesis of 1H-PYRROLO[2,3-B]PYRIDIN-5-OL from 5-Benzyloxy-1H-pyrrolo[2,3-b]pyridine

1H-PYRROLO[2,3-B]PYRIDIN-5-OL Preparation Products And Raw materials

Raw materials

5-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE 5-BROMO-1-TRIISOPROPYLSILANYL-1H-PYRROLO[2,3-B]PYRIDINE 7-Azaindole-5-boronic acid pinacol ester 5-BROMO-PYRROLO[2,3-B]PYRIDINE-1-CARBOXYLICACIDTERT-BUTYLESTER Water

Cupric acetylacetonate Dimethyl sulfoxide Lithium hydroxide monohydrate

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Preparation Products

Methyl 2-[(1H-pyrrolo[2,3-b]pyridin-5-yl)oxy]-4-[4-[[2-(4-chlorophenyl)-4,4-dimethylcyclohex-1-enyl]methyl]piperazin-1-yl]benzoate 5-Benzyloxy-1H-pyrrolo[2,3-b]pyridine

1H-PYRROLO[2,3-B]PYRIDIN-5-OL Suppliers

Global( 304)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
Senova Technology Co. Ltd.	+86-0755-86703119 +8618503098836	info@senovatech.com	China	351	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Hebei Xinsheng New Material Technology Co., LTD.	+86-16632316109	xinshengkeji@xsmaterial.com	China	1085	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	+15184799099	lbaochemicals@gmail.com	China	671	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13902	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29816	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58

Supplier	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	58
Senova Technology Co. Ltd.	58
Hangzhou ICH Biofarm Co., Ltd	58
Hebei Xinsheng New Material Technology Co., LTD.	58
Hefei Lbao Physical & Chemical Science Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58

View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDIN-5-OL manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-18	1H-Pyrrolo[2,3-b]pyridin-5-ol 98549-88-3	US $0.00 / kg	1kg	98%	Customise	Hefei Lbao Physical & Chemical Science Co.,Ltd
2026-03-12	Venetoclax Impurity 12 98549-88-3	US $0.00 / mg	10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD
2026-03-12	Venetoclax Impurity 12 98549-88-3	US $0.00-0.00 / mg	10mg	0.98	10g	ShenZhen H&D Pharmaceutical Technology Co., LTD

1H-Pyrrolo[2,3-b]pyridin-5-ol
98549-88-3
US $0.00 / kg
98%
Hefei Lbao Physical & Chemical Science Co.,Ltd

Venetoclax Impurity 12
98549-88-3
US $0.00 / mg
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

Venetoclax Impurity 12
98549-88-3
US $0.00-0.00 / mg
0.98
ShenZhen H&D Pharmaceutical Technology Co., LTD

1H-PYRROLO[2,3-B]PYRIDIN-5-OL Spectrum

1H-PYRROLO[2,3-B]PYRIDIN-5-OL(98549-88-3)¹HNMR

98549-88-3(1H-PYRROLO[2,3-B]PYRIDIN-5-OL)Related Search:

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5-Hydroxy-7-azaindole 97% 5-hydroxypyrrolo[2,3-b]pyridine 1H-PYRROLO[2,3-B]PYRIDIN-5-OL 1H-Pyrrolo[2,3-b]pyridin-5-ol(6CI,9CI) 5-HYDROXY-1H-PYRROLO[2,3-B]PYRIDINE H-PYRROLO[2,3-B]PYRIDIN-5-OL 5-Hydroxyazaindole 5-Hydroxy-7-azaindole Company Standards 1H-pyrrolo[2,3-b]pyridin-5-ol(For export only) SWF-63 SW-63 1H-Pyrrolo[2,3-b]pyridin-5-ol (6CI, 9CI, ACI) 1H-Pyrrolo[2,3-B]Pridin-5-ol 1H pyrrolo [2,3, B] pyridine-5-ol Vinetola impurity 12 1H-Pyrrolo[2,3-B]Pyridine-5-alcohol 5-HYDROXY-7-AZAINDOLE 98549-88-3 74420-02-4 98549-68-3 PYRIDINE