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ChemicalBook >> CAS DataBase List >>(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Structure
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE structure
CAS No.
247580-43-4
Chemical Name:
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
Synonyms
SB 328437;SB 328437 >=98% (HPLC);SB 328437, CCR3 antagonist;SB 328437 - CAS 247580-43-4 - Calbiochem;SB 328437 (DMSO solution), CCR3 antagonist;(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE;Methyl (S)-2-(1-naphthamido)-3-(4-nitrophenyl)propanoate;Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate;N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester;L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester
CBNumber:
CB4283869
Molecular Formula:
C21H18N2O5
Molecular Weight:
378.38
MDL Number:
MFCD03453566
MOL File:
Mol file
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
Product description Number Pack Size Price
SB-328437 ≥98% 29677 1mg $38
SB-328437 ≥98% 29677 5mg $123
SB-328437 ≥98% 29677 10mg $223
SB 328437 Asreported 256615 10mg $438
SB 328437 Asreported 256615 50mg $1160
Request For Quotation

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Properties

Boiling point 642.9±50.0 °C(Predicted)
Density 1.305±0.06 g/cm3(Predicted)
storage temp. Store at +4°C
solubility DMSO: ≥10mg/mL
pka 12.51±0.46(Predicted)
form White solid
color white to tan
InChI 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChIKey VMFGCGRAIBLAFY-IBGZPJMESA-N
SMILES COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23
UNSPSC Code 12352202
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
Signal word  Warning
Hazard statements  H400-H302
Precautionary statements  P273-P391-P501-P264-P270-P301+P312-P330-P501
Hazard Codes  Xn,N
Risk Statements  22-50
Safety Statements  60-61
WGK Germany  3
Storage Class 11 - Combustible Solids

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE price More Price(39)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29677 SB-328437 ≥98% 247580-43-4 1mg $38 2026-04-30 Buy
Cayman Chemical 29677 SB-328437 ≥98% 247580-43-4 5mg $123 2026-04-30 Buy
Cayman Chemical 29677 SB-328437 ≥98% 247580-43-4 10mg $223 2026-04-30 Buy
Usbiological 256615 SB 328437 Asreported 247580-43-4 10mg $438 2026-06-03 Buy
Usbiological 256615 SB 328437 Asreported 247580-43-4 50mg $1160 2026-06-03 Buy
Product number Packaging Price Buy
29677 1mg $38 Buy
29677 5mg $123 Buy
29677 10mg $223 Buy
256615 10mg $438 Buy
256615 50mg $1160 Buy

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Chemical Properties,Uses,Production

Uses

SB 328437 is a potent and selective CCR3 receptor antagonist.

Biological Activity

SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.', 'SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.

in vivo

SB-328437 (intraperitoneal injection; 5 g/kg; single dose) has a beneficial effect in mouse models of LPS (HY-D1056)-induced lung injury and influenza virus infection[2].

Animal Model:Influenza A strain pmd09 treated C57BL/6 female mice aged 8-10 weeks old (18-20 g) [2]
Dosage:5 g/kg
Administration:Intraperitoneal injection (i.p.); single dose
Result:Reduced neutrophil recruitment to the lung alveolar space.
Reduced tissue damage.
Reduced lung inflammation and the expression of pro-inflammatory cytokines, Tnfa and Cxcl1. Decreased the activation level of neutrophils.
Lowered the viral load in mice.

IC 50

CCR3: 4.5 nM (IC50)

storage

Store at +4°C

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Suppliers

Global( 74)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
Shaanxi Dideu New Materials Co. Ltd 		18192503167 1036@dideu.com China 13278 58
Soochow Chirally Material Science and Technology Co.,Ltd 		+86-51266834346 +86-17751128648 sales@krl-tech.com China 1050 58
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4773 55
Shanghai YuanYe Biotechnology Co., Ltd. 13636370518 shyysw007@163.com China 89667 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 9819 55
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9696 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44926 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shaanxi Dideu New Materials Co. Ltd 		58
Soochow Chirally Material Science and Technology Co.,Ltd 		58
Guangzhou Isun Pharmaceutical Co., Ltd 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Shanghai Chaolan Chemical Technology Center 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58

View Lastest Price from (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SB 328437 pictures 2026-07-27 SB 328437
247580-43-4
 $79.00-278.00 99.54% 10g TargetMol Chemicals Inc.
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE pictures 2026-06-30 (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
247580-43-4
 1KG 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
  • SB 328437 pictures
  • SB 328437
    247580-43-4
  • $79.00-278.00
  • 99.54%
  • TargetMol Chemicals Inc.

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Spectrum

(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE(247580-43-4)1HNMR

247580-43-4((S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE)Related Search:

N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA SB 204741 SB242235 SB 225002 SB 297006
SB 239063 Benzamide, N-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]propyl]-4-nitro-, hydrochloride (1:1) GSK-CXCR2 SB 200646

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SB 328437 (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE SB 328437 - CAS 247580-43-4 - Calbiochem N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester SB 328437 >=98% (HPLC) Methyl (S)-2-(1-naphthamido)-3-(4-nitrophenyl)propanoate SB 328437, CCR3 antagonist SB 328437 (DMSO solution), CCR3 antagonist 247580-43-4