(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
- CAS No.
- 247580-43-4
- Chemical Name:
- (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE
- Synonyms
- SB 328437;SB 328437 >=98% (HPLC);SB 328437, CCR3 antagonist;SB 328437 - CAS 247580-43-4 - Calbiochem;SB 328437 (DMSO solution), CCR3 antagonist;(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE;Methyl (S)-2-(1-naphthamido)-3-(4-nitrophenyl)propanoate;Methyl (2S)-2-(1-naphthoylaMino)-3-(4-nitrophenyl)propanoate;N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalaninemethylester;L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester
- CBNumber:
- CB4283869
- Molecular Formula:
- C21H18N2O5
- Molecular Weight:
- 378.38
- MDL Number:
- MFCD03453566
- MOL File:
- Mol file
| Product description | Number | Pack Size | Price |
| SB 328437 | 29677 | 1mg | $34 |
| SB 328437 | 29677 | 5mg | $111 |
| SB 328437 ≥98% (HPLC) | SML0207 | 5mg | $116 |
| SB 328437 | 29677 | 10mg | $202 |
| SB 328437 ≥99%(HPLC) | 3650 | 10 | $195 |
| Boiling point | 642.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.305±0.06 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility | DMSO: ≥10mg/mL |
| form | White solid |
| pka | 12.51±0.46(Predicted) |
| color | white to tan |
| InChI | 1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1 |
| InChIKey | VMFGCGRAIBLAFY-IBGZPJMESA-N |
| SMILES | COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c2cccc3ccccc23 |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H400-H302 |
| Precautionary statements | P273-P391-P501-P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50 |
| Safety Statements | 60-61 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29677 | SB 328437 | 247580-43-4 | 1mg | $34 | 2024-03-01 | Buy |
| Cayman Chemical | 29677 | SB 328437 | 247580-43-4 | 5mg | $111 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0207 | SB 328437 ≥98% (HPLC) | 247580-43-4 | 5mg | $116 | 2025-07-31 | Buy |
| Cayman Chemical | 29677 | SB 328437 | 247580-43-4 | 10mg | $202 | 2024-03-01 | Buy |
| Tocris | 3650 | SB 328437 ≥99%(HPLC) | 247580-43-4 | 10 | $195 | 2021-12-16 | Buy |
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Chemical Properties,Uses,Production
Uses
SB 328437 is a potent and selective CCR3 receptor antagonist.
Biological Activity
SB 328437 inhibits the recruitment and migration of eosinophils in allergen models of models. It suppresses the Th2-mediated eosinophil infiltration in the airways.', 'SB-328437 is a potent, selective CCR-3 antagonist (IC50 = 1.6 nM). The compound blockes CCR3 agonist-induced calcium mobilization in CCR3 expressing cells with the following IC50 values: eotaxin, 38 nM; eotaxin-2, 35 nM and MCP4, 20 nM.
in vivo
SB-328437 (intraperitoneal injection; 5 g/kg; single dose) has a beneficial effect in mouse models of LPS (HY-D1056)-induced lung injury and influenza virus infection[2].
| Animal Model: | Influenza A strain pmd09 treated C57BL/6 female mice aged 8-10 weeks old (18-20 g) [2] |
| Dosage: | 5 g/kg |
| Administration: | Intraperitoneal injection (i.p.); single dose |
| Result: | Reduced neutrophil recruitment to the lung alveolar space. Reduced tissue damage. Reduced lung inflammation and the expression of pro-inflammatory cytokines, Tnfa and Cxcl1. Decreased the activation level of neutrophils. Lowered the viral load in mice. |
IC 50
CCR3: 4.5 nM (IC50)
storage
Store at +4°C
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32470 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Soochow Chirally Material Science and Technology Co.,Ltd | +86-51266834346 +86-17751128648 | sales@krl-tech.com | China | 942 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4720 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9431 | 55 |
| Shanghai Chaolan Chemical Technology Center | 021-QQ：65489617 15618227136 | Sales@ATKchemical.com | China | 9543 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
