(S)-3-Hydroxypyrrolidine hydrochloride
- CAS No.
- 122536-94-1
- Chemical Name:
- (S)-3-Hydroxypyrrolidine hydrochloride
- Synonyms
- (S)-pyrrolidin-3-ol hydrochloride;TIMTEC-BB SBB004272;(S)-3-hydroxypyrroL;(S)-3-Hydroxypyrro HCl;S-(+)-3-PyrrolidinolHCl;(S)-PYRROLIDIN-3-OL HCL;(3S)-3-Pyrrolidinol HCl;3-(S)-HYDROXYPYRROLIDINE HCL;(S)-3-HYDROXY PYRROLIDINE HCL;3(S)-3-HYDROXY-PYRROLIDINE HCL
- CBNumber:
- CB4294344
- Molecular Formula:
- C4H10ClNO
- Molecular Weight:
- 123.58
- MDL Number:
- MFCD00272298
- MOL File:
- 122536-94-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| (S)-3-HydroxypyrrolidineHydrochloride | H950290 | 1g | $45 |
| (S)-3-HydroxypyrrolidineHCl | N094 | 25g | $54 |
| (S)-pyrrolidin-3-olHydrochloride ≥98.0% | CS-M0906 | 100g | $107 |
| (S)-3-Hydroxypyrrolidinehydrochloride | 112193 | 25g | $115 |
| (S)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE 95.00% | CCH0037859 | 25G | $1264.73 |
| More product size | |||
| Melting point | 104-107°C |
|---|---|
| Boiling point | 108-110℃/8mm |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| color | Off-White to Pale Beige |
| Stability | Hygroscopic |
| InChI | InChI=1/C4H9NO.ClH/c6-4-1-2-5-3-4;/h4-6H,1-3H2;1H/t4-;/s3 |
| InChIKey | QPMSJEFZULFYTB-NDILARRWNA-N |
| SMILES | O[C@@H]1CNCC1.Cl |&1:1,r| |
| CAS DataBase Reference | 122536-94-1(CAS DataBase Reference) |
| FDA UNII | XY8EDF8GSP |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | -36/37/38 | |||||||||
| Safety Statements | 26-37 | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
(S)-3-Hydroxypyrrolidine hydrochloride price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | H950290 | (S)-3-HydroxypyrrolidineHydrochloride | 122536-94-1 | 1g | $45 | 2021-12-16 | Buy |
| AK Scientific | N094 | (S)-3-HydroxypyrrolidineHCl | 122536-94-1 | 25g | $54 | 2021-12-16 | Buy |
| ChemScene | CS-M0906 | (S)-pyrrolidin-3-olHydrochloride ≥98.0% | 122536-94-1 | 100g | $107 | 2021-12-16 | Buy |
| Matrix Scientific | 112193 | (S)-3-Hydroxypyrrolidinehydrochloride | 122536-94-1 | 25g | $115 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0037859 | (S)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE 95.00% | 122536-94-1 | 25G | $1264.73 | 2021-12-16 | Buy |
(S)-3-Hydroxypyrrolidine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
almost white crystalline powder
Uses
(S)-3-Hydroxypyrrolidine Hydrochloride is a useful intermediate for the synthesis of Asimadoline Hydrochlorine (A788250), used in the treatment of IBS, a disorder associated with pain and altered bowel function.
Synthesis
(3S)-N-benzyl-3-hydroxypyrrolidine-2,5-dione (100g), added to a 1L high-pressure reactor, add ethanol 500mL, add 10% palladium carbon (58% water content, model D10H5A, Shaanxi Ruike New Materials Co., Ltd.) 5g, through the hydrogen, keep the pressure of the reaction system 0.5MPa, slowly raise the temperature to 70 , the reaction for 5 hours. The reaction was completed by central control, filtered to recover the palladium carbon, concentrated the solvent, added isopropanol (200 mL) to the residue and stirred to dissolve completely, added concentrated hydrochloric acid (45 mL, 12M, 1.1eq) dropwise, stirred overnight at room temperature, and filtered to obtain a white solid, i.e., 51g of (S)-3-pyrrolidinol hydrochloride, with 85% yield and 99.1% purity.
References
[1] Patent: EP2803664, 2014, A1. Location in patent: Paragraph 0153; 0154
[2] Patent: US2015/5282, 2015, A1. Location in patent: Paragraph 0224; 0225
[3] Patent: CN105646321, 2016, A. Location in patent: Paragraph 0031; 0032
(S)-3-Hydroxypyrrolidine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 | info@rochipharma.com | China | 505 | 58 |
| SHANGHAI SAGACHEM CO., LTD. | +86-02168404722 +86-13816115801 | david_si@shjlchem.com | China | 216 | 58 |
| Chemport Science Technology Shanghai) Co., Ltd. | +undefined13816004845 | chen@chemport-sh.com | China | 188 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21592 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
View Lastest Price from (S)-3-Hydroxypyrrolidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-21 | (S)-3-hydroxypyrrolidine hydrochoride
122536-94-1
|
US $600.00-20000.00 / KG | 1KG | 98% | 2MT per month | Anhui Dexinjia Biopharm Co., Ltd | |
 |
2026-03-20 | (S)-3-Hydroxypyrrolidine hydrochloride
122536-94-1
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-02-02 | (S)-3-Hydroxypyrrolidine hydrochloride
122536-94-1
|
US $0.00-0.00 / KG | 1g | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd |
-
- (S)-3-hydroxypyrrolidine hydrochoride
122536-94-1
- US $600.00-20000.00 / KG
- 98%
- Anhui Dexinjia Biopharm Co., Ltd
-
- (S)-3-Hydroxypyrrolidine hydrochloride
122536-94-1
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- (S)-3-Hydroxypyrrolidine hydrochloride
122536-94-1
- US $0.00-0.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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