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L-Malic acid

L-Malic acid Structure
L-Malic acid structure
CAS No.
97-67-6
Chemical Name:
L-Malic acid
Synonyms
L-MALIC ACID;L-(-)-MALIC ACID;(2S)-2-hydroxybutanedioic acid;L-Malic;apple acid;L-Mailcacid;HYDROXYBUTANEDIOIC ACID;L-Gydroxybutanedioicacid;pinguosuan;(S)-(-)-MALIC ACID
CBNumber:
CB0493594
Molecular Formula:
C4H6O5
Molecular Weight:
134.09
MDL Number:
MFCD00064213
MOL File:
97-67-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-20 20:20:01
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L-Malic acid Properties

Melting point 101-103 °C (lit.)
alpha -2 º (c=8.5, H2O)
Boiling point 167.16°C (rough estimate)
bulk density 600kg/m3
Density 1.60
vapor pressure 0Pa at 25℃
FEMA 2655 | L-MALIC ACID
refractive index -6.5 ° (C=10, Acetone)
Flash point 220 °C
storage temp. Store below +30°C.
solubility H2O: 0.5 M at 20 °C, clear, colorless
form Powder
color White
Specific Gravity 1.595 (20/4℃)
Odor odorless
PH 2.2 (10g/l, H2O, 20℃)
pka (1) 3.46, (2) 5.10(at 25℃)
Odor Type odorless
biological source microbial
optical activity [α]20/D 30±2°, c = 5.5% in pyridine
Water Solubility soluble
Merck 14,5707
JECFA Number 619
BRN 1723541
Cosmetics Ingredients Functions BUFFERING
InChI 1S/C4H6O5/c5-2(4(8)9)1-3(6)7/h2,5H,1H2,(H,6,7)(H,8,9)/t2-/m0/s1
InChIKey BJEPYKJPYRNKOW-REOHCLBHSA-N
SMILES O[C@@H](CC(O)=O)C(O)=O
LogP -1.68
SCOGS (Select Committee on GRAS Substances) L-Malic acid
CAS DataBase Reference 97-67-6(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS) L-MALIC ACID
FDA UNII J3TZF807X5
NIST Chemistry Reference Butanedioic acid, hydroxy-, (s)-(97-67-6)
EPA Substance Registry System Butanedioic acid, 2-hydroxy-, (2S)- (97-67-6)
UNSPSC Code 51113400
NACRES NA.75

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-37/39
WGK Germany  3
RTECS  ON7175000
TSCA  TSCA listed
HS Code  29181980
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
REACH Registrations Active
NFPA 704
0
2 0

L-Malic acid price More Price(107)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.00384 L-(-)-Malic acid for resolution of racemates for synthesis 97-67-6 5G $29.7 2026-04-30 Buy
Sigma-Aldrich 8.00384 L-(-)-Malic acid for resolution of racemates for synthesis 97-67-6 10g $43.4 2026-04-30 Buy
Sigma-Aldrich 8.00384 L-(-)-Malic acid for resolution of racemates for synthesis 97-67-6 50g $109 2026-04-30 Buy
Sigma-Aldrich 8.00384 L-(-)-Malic acid for resolution of racemates for synthesis 97-67-6 500g $449 2026-04-30 Buy
Sigma-Aldrich 8.00384 L-(-)-Malic acid for resolution of racemates for synthesis 97-67-6 1kg $876 2026-04-30 Buy
Product number Packaging Price Buy
8.00384 5G $29.7 Buy
8.00384 10g $43.4 Buy
8.00384 50g $109 Buy
8.00384 500g $449 Buy
8.00384 1kg $876 Buy

L-Malic acid Chemical Properties, Uses, Production

Description

L-Malic acid is nearly odorless (sometimes a faint, acrid odor) with a tart, acidic taste. It is nonpungent. May be prepared by hydration of maleic acid; by fermentation from sugars.

Chemical Properties

L-Malic acid is nearly odorless (sometimes a faint, acrid odor). This compound has a tart, acidic, nonpungent taste.

Chemical Properties

clear colourless solution

Occurrence

Occurs in maple sap, apple, melon, papaya, beer, grape wine, cocoa, sake, kiwifruit and chicory root.

Uses

L-Malic acid is used as a food additive, Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.

Uses

The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid rece

Uses

Intermediate in chemical synthesis. Chelating and buffering agent. Flavoring agent, flavor enhancer and acidulant in foods.

Definition

ChEBI: An optically active form of malic acid having (S)-configuration.

Preparation

L-Malic acid can be prepared by hydration of maleic acid; by fermentation from sugar.

General Description

L-Malic acid is an organic acid that is commonly found in wine. It plays an important role in wine microbiological stability.

Biochem/physiol Actions

L-Malic acid is a part of cellular metabolism. Its application is recognized in pharmaceutics. It is useful in the treatment of hepatic malfunctioning, effective against hyper-ammonemia. It is used as a part of amino acid infusion. L-Malic acid also serves as a nanomedicine in the treatment of brain neurological disorders. A TCA (Krebs cycle) intermediate and partner in the malic acid aspartate shuttle.

Purification Methods

Crystallise S-malic acid (charcoal) from ethyl acetate/pet ether (b 55-56o), keeping the temperature below 65o. Or dissolve it by refluxing in fifteen parts of anhydrous diethyl ether, decant, concentrate to one-third volume and crystallise it at 0o, repeatedly to constant melting point. [Beilstein 3 IV 1123.]

L-Malic acid synthesis

1009815-87-5
640-68-6
72-18-4
97-67-6
1127229-10-0
1127229-09-7
56-40-6
Synthesis of L-Malic acid from Largazole

L-Malic acid Preparation Products And Raw materials

Raw materials

Calcium carbonate Disodium fumarate Poly(acrylic acid) (2S)-1-(3-Acetylthio-2-methyl-1-oxopropyl)-L-proline

Preparation Products

Fluorescent Brightener 135 (S)-(+)-3-Hydroxytetrahydrofuran (-)-(1S,4R)-4-Aminocyclopent-2-enecarboxylic acid (R)-(-)-3-Quinuclidinol (S)-1-Benzyl-3-pyrrolidinol
(S)-3-Hydroxypyrrolidine hydrochloride Diethyl malate (R)-3-Quinuclidinol hydrochloride Coumalic acid Chlorosuccinic acid
2,5-Pyrrolidinedione, 3-(acetyloxy)-, (3S)- Butanedioic acid, 2-hydroxy-, 1-(phenylmethyl) ester, (2S)- Cabozantinib Malate

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L-Malic acid Suppliers

Global Suppliers ( 848)
Supplier Tel Email Country ProdList Advantage
Jinan Daen Pharmaceutical Technology Co., Ltd 0531-68657833 15905416458 2098511197@qq.com China 283 58
Changzhou Success Chemical Co., Ltd. 18961148122; 18961148122 278954761@qq.com China 34 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939 shenlinxing@macklin.cn China 29676 58
ShangHai ZskBio CO., LTD 021-58056897 15399714481 info@zsklab.com China 7539 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Jinan Daen Pharmaceutical Technology Co., Ltd 58
Changzhou Success Chemical Co., Ltd. 58
Shanghai Maclean Biochemical Technology Co., LTD 58
ShangHai ZskBio CO., LTD 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
future industrial shanghai co., ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81

Related articles

View Latest Price from L-Malic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-(-)-Malic Acid pictures 2026-09-17 L-(-)-Malic Acid
97-67-6
 0.99 RongNa Biotechnology Co.,Ltd
L-(-)-Malic Acid pictures 2026-09-17 L-(-)-Malic Acid
97-67-6
 1KG 99%min 1000kgs WUHAN FORTUNA CHEMICAL CO., LTD
L-Malic acid pictures 2026-09-17 L-Malic acid
97-67-6
 $4.00-7.00 25g 0.99 100kg Shanghai UCHEM Inc.

L-Malic acid Spectrum

L-(-)-Malic Acid(97-67-6)MSL-(-)-Malic Acid(97-67-6)1HNMRL-(-)-Malic Acid(97-67-6)13CNMRL-(-)-Malic Acid(97-67-6)IR1L-(-)-Malic Acid(97-67-6)IR2L-(-)-Malic Acid(97-67-6)Raman

97-67-6 (L-Malic acid) Related Search:

Ethyl 2-(Chlorosulfonyl)acetate Dimethyl succinate 2,3-Dibromosuccinic acid Disodium succinate D(-)-Tartaric acid
Folic acid DL-Malic acid Ammonium succinate Succinic acid D(+)-Malic acid
Citric acid Glycine Ascoric Acid Oxaloacetic acid 3,4-dihydroxybutanoic acid
Malic acid 4-Me ester L-Carnosine 2-Hydroxysuccinic acid methyl ester

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L-(-)-Malic acid, CP Butanedioic acid, 2-hydroxy-, (2S)- pinguosuan Butanedioicacid,hydroxy-,(S)- hydroxy-,(S)-Butanedioicacid l-(ii)-malicacid L-Gydroxybutanedioicacid L-Mailcacid L(-)-Malic acid, 30 wt% aqueous solution Butanedioic acid, hydroxy-, (2S)- L-MALIC ACID L L-LYSINEMONOHCL L-MALIC ACID / (S)-(-)-HYDROXYSUCCINIC ACID (S)-(-)-2-Hydroxysuccinic acid, L-Hydroxybutanedioic acid S-2-Hydroxybutanedioic acid )-Malic ac L-()-Malic ac L(-)-Malic acid, 99% 25GR L-2-Hydroxybutanedioic acid L-(-)-MALIC ACID FOR RESOLUTION OF RACEM L-(-)-Malic acid 95-100% (enzyMatic) L-(-)-Malic acid 97%, optical purity ee: 99% (GLC) L-(-)-Malic acid ReagentPlus(R), >=99% L-(-)-Malic Acid, 97+% L-(-)-Malicacid,98+% L-(-)-Malicacid,99% L-(-)-ALIC ACID, AQUEOUS SOLUTION L-(-)-Malic acid Vetec(TM) reagent grade, 97% malic acid ,Hydrozybutanedioic acid (S)-(-)-2-Hydroxysuccinic acid L-Hydroxybutanedioic acid Apple acid L-(-)-Apple Acid (S)-(-)-HYDROXYSUCCINIC ACID (S)-HYDROXYSUCCINIC ACID (S)-HYDROXYBUTANEDIOIC ACID (S)-(-)-MALIC ACID (S)-2-HYDROXYBUTANEDICARBOXYLIC ACID S(-)-2-HYDROXYSUCCINIC ACID NATURAL APPLE ACID HYDROXYBUTANEDIOIC ACID L-HYDROXYSUCCINIC ACID L-HYDROXYBUTANEDIOIC ACID L-(-)-APPLE ACID L-APPLE ACID L(-)-MALATE (-)-L-MALIC ACID L-MALIC ACID MALIC ACID, L-(-)- 2-HYDROXYSYCCINIC ACID 1-HYDROXYSUCCINIC ACID L-Maleic Acid L(+-)MALIC ACID FREE ACID INSECT CELL*CU LTURE TESTE L-MALIC ACID FREE ACID CRYSTALLINE L(-)MALIC ACID FREE ACID PLANT CELL*CULT URE TESTED L (-) MALIC ACID SIGMAULTRA L-MALIC ACID 99+% FCC L-MALIC ACID BIOTECH GRADE 99.5% L-(-)-MalicAcid> CultureSure L(-)-Malic Acid, Animal-derived-free -(-)-MaL