ChemicalBook >> CAS DataBase List >>trans-4-Hydroxy-L-proline methyl ester hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride

trans-4-Hydroxy-L-proline methyl ester hydrochloride structure

CAS No.: 40216-83-9

Chemical Name:: trans-4-Hydroxy-L-proline methyl ester hydrochloride

Synonyms: METHYL (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE;H-HYP-OME HCL;H-HYP-OME·HCL;(4R)-4-Hydroxy-L-proline methyl ester HCl;L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE;4-Hydroxy-L-proline methyl ester hydrochloride;trans-4-Hydroxyproline Methyl Ester Hydrochloride;(2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE;(2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride;Hyp-Ome HCL

CBNumber:: CB9351552

Molecular Formula:: C6H12ClNO3

Molecular Weight:: 181.62

MDL Number:: MFCD00080855

MOL File:: 40216-83-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:31:41

Request For Quotation

trans-4-Hydroxy-L-proline methyl ester hydrochloride Properties

Melting point	169 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
form	Solid
color	White to Off-White
BRN	4716932
Stability	Hygroscopic
Major Application	peptide synthesis
InChI	InChI=1/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/s3
InChIKey	KLGSHNXEUZOKHH-SRJSDOSHNA-N
SMILES	[C@@H]1(NC[C@H](O)C1)C(=O)OC.Cl \|&1:0,3,r\|
CAS DataBase Reference	40216-83-9(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319-H315-H335

Precautionary statements

P261-P271-P280

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Safety Statements

24/25

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

trans-4-Hydroxy-L-proline methyl ester hydrochloride price More Price(94)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	30681	L-4-Hydroxyproline methyl ester hydrochloride ≥98.0% (TLC)	40216-83-9	5g	$64.3	2026-04-30	Buy
TCI Chemical	H1533	trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride	40216-83-9	5G	$29	2026-04-30	Buy
TCI Chemical	H1533	trans-4-Hydroxy-L-proline Methyl Ester Hydrochloride	40216-83-9	25G	$94	2026-04-30	Buy
Usbiological	279443	trans-4-Hydroxy-L-proline methyl ester hydrochloride	40216-83-9	50g	$337	2026-06-03	Buy
Usbiological	279443	trans-4-Hydroxy-L-proline methyl ester hydrochloride	40216-83-9	100g	$468	2026-06-03	Buy

Product number	Packaging	Price	Buy
30681	5g	$64.3	Buy
H1533	5G	$29	Buy
H1533	25G	$94	Buy
279443	50g	$337	Buy
279443	100g	$468	Buy

trans-4-Hydroxy-L-proline methyl ester hydrochloride Chemical Properties, Uses, Production

Chemical Properties

White Solid

Uses

trans-4-Hydroxy-L-proline (H952376) derivative. A natural constituent of animal structural proteins such as collagen and elastin.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

67-56-1

32968-78-8

40216-83-9

The general procedure for synthesizing trans-4-hydroxy-L-proline methyl ester hydrochloride from methanol and trans-4-hydroxy-L-proline hydrochloride is as follows: Example 1: (2S,4R)-4-hydroxy-2-pyrrolidine carboxylic acid hydrochloride (1.0 g, 7.6 mmol) was dissolved in methanol (25 mL) and cooled to 0°C. Thionyl chloride (0.83 mL, 11.4 mmol) was added slowly under stirring. The reaction mixture was gradually warmed to room temperature and subsequently heated to reflux overnight. After completion of the reaction, it was cooled to room temperature and the reaction mixture was concentrated to dryness under reduced pressure to afford trans-4-hydroxy-L-proline methyl ester hydrochloride (1.2 g, 92% yield) in white solid form. The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6).

IC 50

Non-cleavable Linker

References

[1] Organic Letters, 2018, vol. 20, # 1, p. 162 - 165
[2] Patent: WO2013/174937, 2013, A1. Location in patent: Page/Page column 74
[3] Patent: US2015/152048, 2015, A1. Location in patent: Paragraph 0447-0448

trans-4-Hydroxy-L-proline methyl ester hydrochloride synthesis

Synthesis of trans-4-Hydroxy-L-proline methyl ester hydrochloride from Methanol and Boc-Hyp-OH

trans-4-Hydroxy-L-proline methyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Methanol Trans-4-Hydroxy-L-proline Hydrochloride Boc-Hyp-OH L-Hydroxyproline Acetyl chloride

Preparation Products

N-Boc-4-oxo-L-Proline methyl ester 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine N-BOC-cis-4-fluoro-L-proline (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-methyl ester hydrochloride Glycine, L-prolyl-(4R)-4-hydroxy-L-prolyl-

trans-4-Hydroxy-L-proline methyl ester hydrochloride Suppliers

Global Suppliers ( 419)

Supplier	Tel	Email	Country	ProdList	Advantage
YangZhou Ruihong Biotech Co., Ltd.	0514-015380367604 15380367604	sales@ruibobiotech.com	China	509	55
Nantong puyue biomedical Co., Ltd	0513-0513-0513-89158300 18014392889	sales@puyerbiopharma.com	China	4956	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544 15366717810	sales@thbiochem.com	China	407	55
Nanjing Danron Bio-New Materials Co.Ltd	18936428028 18936428028	3806853067@qq.com	China	147	58
Wuhan Mayue Longteng Technology Development Co., Ltd.	132-37125928 15171477138	2428374547@qq.com	China	52	58
Yangzhou Xuda Biotechnology Co., Ltd	15161820588; 15161820588	xdchemical2024@163.com	China	91	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56

Supplier	Advantage
YangZhou Ruihong Biotech Co., Ltd.	55
Nantong puyue biomedical Co., Ltd	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	55
Nanjing Danron Bio-New Materials Co.Ltd	58
Wuhan Mayue Longteng Technology Development Co., Ltd.	58
Yangzhou Xuda Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56

View Latest Price from trans-4-Hydroxy-L-proline methyl ester hydrochloride manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	trans-4-Hydroxy-L-proline methyl ester hydrochloride 40216-83-9	100g	98.0%min	500kgs	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-17	H-L-Hyp-Ome·HCl 40216-83-9	1kg	98%	1T+	Sichuan HongRi Pharma-Tech Co.,Ltd
2024-11-26	trans-4-Hydroxy-L-proline methyl ester hydrochloride 40216-83-9	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd

trans-4-Hydroxy-L-proline methyl ester hydrochloride
40216-83-9
$0.00
98.0%min
WUHAN FORTUNA CHEMICAL CO., LTD

H-L-Hyp-Ome·HCl
40216-83-9
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

trans-4-Hydroxy-L-proline methyl ester hydrochloride
40216-83-9
98%
Nanjing Fred Technology Co., Ltd

trans-4-Hydroxy-L-proline methyl ester hydrochloride Spectrum

trans-4-Hydroxy-L-proline methyl ester hydrochloride(40216-83-9)¹HNMR

40216-83-9 (trans-4-Hydroxy-L-proline methyl ester hydrochloride) Related Search:

Topotecan hydrochloride Kresoxim-methyl 4-Hydroxyaniline hydrochloride cis-4-Hydroxy-L-proline Methyl glycolate

Methylparaben L-Hydroxyproline Methyl acrylate Methyl L-prolinate hydrochloride D-Proline

Bensulfuron methyl Trans-4-Hydroxy-L-proline Hydrochloride Thiophanate-methyl Chlorophosphonazo III L-Proline-(4-3H(n))

H-Hyp(tBu)-OH H-Hyp(Bzl)-OH HCl trans-4-Hydroxy-D-proline

1of4

H-HYP-OME HCL H-L-HYP-OME HCL HYDROXYPROLINE-OME HCL (2S,4R)-trans-4-hydroxy-L-proline methyl ester hydrochloride 4-hydroxy-2-pyrrolidinecarboxylic acid methyl ester hydrochloride L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE L-4-TRANS-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT L-TRANS-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE SALT L-HYDROXYPROLINE METHYL ESTER HCL L-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE (2S,4R)-2-CARBOMETHOXY-4-HYDROXYPYRROLIDINE HYDROCHLORIDE TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HYDROCHLORIDE SALT TRANS-L-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE TIMTEC-BB SBB003740 4-HYDROXY-L-PROLINE METHYL ESTER HCl (2s,4r)-Methyl 4-Hydroxy-Pyrrolidine-2-Carboxylate HCl Hyp-Ome HCL (2S,4R)-4-hydroxy-L-proline methyl ester L-4-HYDROXYPROLINE METHYL ESTER HYDROCHL (2R,4S)-4-hydroxy-D-proline methyl ester Methyl (2S,4R)-4-hydroxy-2-prolinate hydrochloride 4-Hydroxy-L-proline methyl ester hydrochloride TRANS-4-HYDROXY-L-PROLINE METHYL ESTER HCL L-Hyp-OMe·HCl L-4-trans-Hydroxyproline methyl ester hydrochloride≥ 97% (HPLC) H-Hyp-OMe·HCl (Non-animal Origin) Hydroxyproline methyl ester hydrochloride L-4-Hydroxyproline methyl ester hydrochloride ,98% Methyl (2S,4R)-4-Hydroxy-2-pyrrolidinecarboxylate Hydrochloride Methyl L-Hydroxyprolinate Hydrochloride Methyl trans-4-Hydroxy-L-prolinate Hydrochloride trans-4-Hydroxyproline Methyl Ester Hydrochloride trans-4-Hydroxy-L-proline Methyl ester hydrochloride trans-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride 4-hydroxy-pyrrolidine-2-carboxylic acid Methyl ester hydrochloride Trans-4-hydroxyl-lprolinemethylesterhydrochloride Methyl (2S)-1-hydroxypyrrolidine-2-carboxylate hydrochloride L-(S)-4-Hydroxyproline Methyl Ester Hydrochloride trans-4-Hydroxy-L-proline methyl ester hydrochloride, Methyl (4R)-4-hydroxy-L-prolinate hydrochloride L-4-Hydroxyproline Methyl ester hydrochloride >=98.0% (TLC) L-4-Hydroxyproline Methyl ester hydrochloride, 95+% L-4-Hydroxyproline methyl ester trans-4-Hydroxy-L-prolineMethylEsterHydrochloride> -4-HydroxyproL (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester Hydrochloride trans-4-Hydroxy-L-proline methyl ester hydrochloride USP/EP/BP H-Hyp-OMe (hydrochloride) (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic Acid Methyl Ester HCl (2S,4R)-methyl 4-hydroxypyrrolidine-2-carboxylate Hydrochloride/trans-4-HYDROXY-L-PROLINE METHYL ESTER Hydrochloride L-4-Hydroxyproline methyl ester hydrochloride (2S,4R)-Methyl 4-hydroxypyrrolidine-2-carboxylate hydrochloride (4R)-4-Hydroxy-L-proline methyl ester HCl H-HYP-OME·HCL L-4-HYDROXYPROLINE METHYL ESTER HYDROCHLORIDE METHYL (2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLATE HYDROCHLORIDE 40216-83-9