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6-Bromo-1H-indole

6-Bromo-1H-indole structure

CAS No.: 52415-29-9

Chemical Name:: 6-Bromo-1H-indole

Synonyms: bromoindole;6-BROMOINDOLE;EOS-60560;BROMOINDOLE-6;6-BROMO-1H-INDOLE;6-Bromoindole,96%;6-Bromoindole,98%;6-broMo-3H-indole;6-BROMOINDOLE 98%;6-Bromoindole >

CBNumber:: CB9663460

Molecular Formula:: C8H6BrN

Molecular Weight:: 196.04

MDL Number:: MFCD00238550

MOL File:: 52415-29-9.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:51

Product description	Number	Pack Size	Price
6-Bromoindole 96%	524344	1g	$62.37
6-Bromoindole 96%	524344	5g	$223
6-Bromoindole >98.0%(GC)	B1794	1g	$58
6-Bromoindole >98.0%(GC)	B1794	5g	$172
6-Bromoindole	B684560	5g	$525
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6-Bromo-1H-indole Properties

Melting point	92-96 °C (lit.)
Boiling point	70-75°C 0,01mm
Density	1.660±0.06 g/cm3(Predicted)
Flash point	70-75°C/0.01mm
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	16.07±0.30(Predicted)
form	Powder
color	White to brown
Sensitive	Air & Light Sensitive
BRN	112711
InChI	InChI=1S/C8H6BrN/c9-7-2-1-6-3-4-10-8(6)5-7/h1-5,10H
InChIKey	MAWGHOPSCKCTPA-UHFFFAOYSA-N
SMILES	N1C2=C(C=CC(Br)=C2)C=C1
CAS DataBase Reference	52415-29-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-37/39

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

6-Bromo-1H-indole price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	524344	6-Bromoindole 96%	52415-29-9	1g	$62.37	2025-07-31	Buy
Sigma-Aldrich	524344	6-Bromoindole 96%	52415-29-9	5g	$223	2025-07-31	Buy
TCI Chemical	B1794	6-Bromoindole >98.0%(GC)	52415-29-9	1g	$58	2025-07-31	Buy
TCI Chemical	B1794	6-Bromoindole >98.0%(GC)	52415-29-9	5g	$172	2025-07-31	Buy
TRC	B684560	6-Bromoindole	52415-29-9	5g	$525	2021-12-16	Buy

Product number	Packaging	Price	Buy
524344	1g	$62.37	Buy
524344	5g	$223	Buy
B1794	1g	$58	Buy
B1794	5g	$172	Buy
B684560	5g	$525	Buy

6-Bromo-1H-indole Chemical Properties,Uses,Production

Chemical Properties

White to brown powder

Uses

6-Bromoindole is a starting material in the synthesis of various indole derivatives.

Uses

Essential starter in 6-substituted indole chemistry.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 249, 1984 DOI: 10.1021/jo00176a007

General Description

6-Bromoindole is an indole derivative. It undergoes palladium-catalyzed reaction with 2-(4-fluorophenyl)ethylpiperazine to afford the carbonylation products.

Synthesis

60956-26-5

4637-24-5

52415-29-9

Step A: Under nitrogen protection, 4-bromo-2-nitrotoluene (7.9 g, 36.6 mmol) was dissolved in anhydrous N,N-dimethylformamide (73 mL), and N,N-dimethylformamide dimethyl acetal (14.5 mL, 110 mmol) and pyrrolidine (4.7 mL) were added sequentially. The reaction mixture was heated and stirred in an oil bath at 110 °C for 90 min. After completion of the reaction, the mixture was cooled to room temperature, diluted with ether (200 mL), and washed with deionized water (3 × 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was dissolved in 80% aqueous acetic acid (245 mL) and heated to 75 °C. Under stirring, zinc powder (20.8 g, 318 mmol) was added in batches for 2 hours. After addition, the reaction mixture was warmed to 85 °C and stirring was continued for 3.5 hours. After completion of the reaction, the mixture was cooled to room temperature and then to 0 °C in an ice bath and filtered to remove insoluble matter. The filtrate was diluted with ethyl acetate (200 mL) and washed with deionized water (2 × 100 mL). The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give a brown oily crude product. The crude product was purified by fast column chromatography with the eluent being a mixed solvent of hexane/ethyl acetate in the order of 95:5 and 90:10 to give 6-bromoindole as a gray solid (2.61 g, 36% yield). The structure of the product was confirmed by 1H NMR (500 MHz, CDCl3): δ 8.14 (br s, 1H), 7.53 (s, 1H), 7.49 (d, J = 8.4 Hz, 1H), 7.21 (dd, J = 8.4, 1.7 Hz, 1H), 7.17-7.15 (m, 1H), 6.53-6.51 (m, 1H).

References

[1] Journal of Organic Chemistry, 2004, vol. 69, # 20, p. 6812 - 6820
[2] RSC Advances, 2014, vol. 4, # 9, p. 4672 - 4675
[3] Patent: US2006/52378, 2006, A1. Location in patent: Page/Page column 154
[4] Tetrahedron, 1999, vol. 55, # 4, p. 935 - 942
[5] Patent: US2011/46370, 2011, A1. Location in patent: Page/Page column 10

6-Bromo-1H-indole Preparation Products And Raw materials

Raw materials

4-Bromo-2-nitrotoluene EthenaMine, 2-(4-broMo-2-nitrophenyl)-N,N-diMethyl- N,N-Dimethylformamide dimethyl acetal N,N-Dimethylformamide Pyrrolidine

Acetic acid ZINC

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Preparation Products

6-Bromoindole-3-carboxaldehyde 7-bromoquinoline-4-carboxylic acid AKOS B006681 Indole-6-boronic acid Indole-6-boronic acid pinacol ester

3H-Indol-3-one, 6-bromo-2-(6-bromo-1,3-dihydro-3-oxo-2H-indol-2-ylidene)-1,2-dihydro- Indole 6-Bromoisatin 3-IODO-6-BROMO INDOLE 6-Bromo-3-(1-methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

1H-INDOLE-3-ACETIC ACID, 6-BROMO-α-OXO- 6-Bromo-1-(tert-butyldimethylsilyl)indole

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6-Bromo-1H-indole Suppliers

Global( 487)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13451	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29850	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2161	58
Shanghai Arbor Chemical Co., Ltd.	021-60451682	act@arborchemical.com	CHINA	904	58
Win-Win Chemical CO., Limited	0086-577-64498589	sales@win-winchemical.com	CHINA	998	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10405	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shanghai Arbor Chemical Co., Ltd.	58
Win-Win Chemical CO., Limited	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58

View Lastest Price from 6-Bromo-1H-indole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-04-04	6-Bromo-1H-indole 52415-29-9	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2025-01-03	6-Bromo-1H-indole 52415-29-9	US $0.00-0.00 / KG	1g	99%	2000tons	Shaanxi Dideu Medichem Co. Ltd
2020-06-02	6-Bromoindole in stock Factory 52415-29-9	US $1.00 / KG	1KG	TOP 3 Factory in China	Top 3 largest production capacity Factory	Chemwill Asia Co.,Ltd.

6-Bromo-1H-indole
52415-29-9
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

6-Bromo-1H-indole
52415-29-9
US $0.00-0.00 / KG
99%
Shaanxi Dideu Medichem Co. Ltd

6-Bromoindole in stock Factory
52415-29-9
US $1.00 / KG
TOP 3 Factory in China
Chemwill Asia Co.,Ltd.

6-Bromo-1H-indole Spectrum

6-Bromo-1H-indole(52415-29-9)MS 6-Bromo-1H-indole(52415-29-9)¹HNMR 6-Bromo-1H-indole(52415-29-9)¹³CNMR 6-Bromo-1H-indole(52415-29-9)IR1 6-Bromo-1H-indole(52415-29-9)IR2

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EOS-60560 6-Bromoindole in stock Factory bromoindole BROMOINDOLE-6 6-BROMO-1H-INDOLE 6-BROMOINDOLE 6-Bromoindole,98% bromoindole 6-Bromoindole 6-Bromoindole,96% 1H-Indole, 6-broMo- 6-broMo-3H-indole 6-BROMOINDOLE 98% 6-Bromoindole > 52415-29-9 54415-29-9 52415-29-2 Building Blocks ARYL HALIDE Indoles Simple Indoles Heterocyclic Building Blocks Halogenated Heterocycles Heterocycle-Indole series Simple Indoles Halogenated Heterocycles Heterocyclic Building Blocks IndolesBuilding Blocks pharmacetical Indole Indoles Heterocyclic Compounds Halogenated Organohalides blocks Bromides IndolesOxindoles Indole/indoline/oxindole Indoles and derivatives