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2-Bromo-3-methoxypyridine

2-Bromo-3-methoxypyridine Structure
2-Bromo-3-methoxypyridine structure
CAS No.
24100-18-3
Chemical Name:
2-Bromo-3-methoxypyridine
Synonyms
AKOS BBS-00006021;TIMTEC-BB SBB005633;BROMO-3-METHOXYPYRIDINE;2-BROMO-3-METHOXYPYRIDI;2-Bromo-3-methoxypyridine;Pyridine,2-bromo-3-methoxy-;2-Bromo-3-methoxypyridine >2-BROMO-3-METHOXYPYRIDINE, 98+%;2-BROMO-3-METHOXYPYRIDINE, PURUM, 97%;2-BROMO-3-METHOXYPYRIDINE ISO 9001：2015 REACH
CBNumber:
CB4354149
Molecular Formula:
C6H6BrNO
Molecular Weight:
188.02
MDL Number:
MFCD01570896
MOL File:
24100-18-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:45
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2-Bromo-3-methoxypyridine Properties

Melting point 45-49 °C (lit.)
Boiling point 233.4±20.0 °C(Predicted)
Density 1.530±0.06 g/cm3(Predicted)
Flash point >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Dichloromethane
pka -0.51±0.10(Predicted)
form Crystalline Powder
color White to cream
InChI InChI=1S/C6H6BrNO/c1-9-5-3-2-4-8-6(5)7/h2-4H,1H3
InChIKey PDOWLYNSFYZIQX-UHFFFAOYSA-N
SMILES C1(Br)=NC=CC=C1OC
CAS DataBase Reference 24100-18-3(CAS DataBase Reference)
FDA UNII SQN9M14S1Y
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn
Risk Statements  22-37/38-41
Safety Statements  26-39
WGK Germany  3
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Bromo-3-methoxypyridine price More Price(91)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 649716 2-Bromo-3-methoxypyridine 97% 24100-18-3 1g $31.2 2023-06-20 Buy
Sigma-Aldrich 649716 2-Bromo-3-methoxypyridine 97% 24100-18-3 10g $278 2023-06-20 Buy
TCI Chemical B3861 2-Bromo-3-methoxypyridine >98.0%(GC) 24100-18-3 5g $95 2026-04-30 Buy
TCI Chemical B3861 2-Bromo-3-methoxypyridine >98.0%(GC) 24100-18-3 25g $339 2026-04-30 Buy
Usbiological B2860-48 2-Bromo-3-methoxy-pyridine 24100-18-3 250mg $425 2026-06-03 Buy
Product number Packaging Price Buy
649716 1g $31.2 Buy
649716 10g $278 Buy
B3861 5g $95 Buy
B3861 25g $339 Buy
B2860-48 250mg $425 Buy

2-Bromo-3-methoxypyridine Chemical Properties, Uses, Production

Chemical Properties

2-BROMO-3-METHOXYPYRIDINE is Light yellow Cryst

Uses

2-BROMO-3-METHOXYPYRIDINE is used in the preparation of triazolopyrimidine derivatives and analogs as AXL receptor tyrosine kinase function inhibitors.

Synthesis Reference(s)

Tetrahedron, 42, p. 1475, 1986 DOI: 10.1016/S0040-4020(01)87367-1

Synthesis

2-Bromo-3-hydroxypyridine

6602-32-0

Iodomethane

74-88-4

2-BROMO-3-METHOXYPYRIDINE

24100-18-3

Under nitrogen protection, sodium hydride (605 mg, 15.1 mmol) was added in batches to ice-cooled methanol (10 mL). After stirring for 20 min, a solution of 2-bromo-3-hydroxypyridine (2.5 g, 14.4 mmol) in dimethylformamide (20 mL) was added to the reaction system. Subsequently, methanol was removed by distillation under reduced pressure and iodomethane (0.94 mL, 15.1 mmol) was added to the residue. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was concentrated to dryness and the residue was treated with water (50 mL) and ether (50 mL). The organic layer was separated and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic phase was dried with anhydrous magnesium sulfate and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 8:1) to afford the target compound 2-bromo-3-methoxypyridine (1.51 g, 56% yield) as colorless needle-like crystals. The product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 3.90 (3H, s), 7.12 (1H, m), 7.21 (1H, dd, J = 4.8, 8.0 Hz), 7.97 (1H, m). IR (ATR) showed characteristic absorption peaks: 1556, 1410, 1076, 1049, 788 cm-1. The melting point is 34°C.

References

[1] Chemische Berichte, 1983, vol. 116, # 6, p. 2394 - 2397
[2] Patent: EP1466898, 2004, A1. Location in patent: Page 100
[3] Tetrahedron, 1986, vol. 42, # 5, p. 1475 - 1485
[4] Patent: US2003/212110, 2003, A1
[5] Patent: US6166006, 2000, A

2-Bromo-3-methoxypyridine Preparation Products And Raw materials

Raw materials

Methanol 2-Bromo-3-hydroxypyridine Iodomethane Sodium hydride

Preparation Products

5'-hydroxypiroxicam 2-Bromo-5-methoxypyridine 2-Bromo-3-methoxypyridine-N-oxide

2-Bromo-3-methoxypyridine Suppliers

Global Suppliers ( 290)
Supplier Tel Email Country ProdList Advantage
Shanghai Kaiwei Chemical Technology Co., Ltd. 021-58461859 15821823057 service@aiviche.com China 49299 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Supplier Advantage
Shanghai Kaiwei Chemical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64

View Latest Price from 2-Bromo-3-methoxypyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-BROMO-3-METHOXYPYRIDINE pictures 2026-09-02 2-BROMO-3-METHOXYPYRIDINE
24100-18-3
 $5.00 1KG 98% Henan Fengda Chemical Co., Ltd
2-BROMO-3-METHOXYPYRIDINE pictures 2026-08-20 2-BROMO-3-METHOXYPYRIDINE
24100-18-3
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-BROMO-3-METHOXYPYRIDINE pictures 2026-06-30 2-BROMO-3-METHOXYPYRIDINE
24100-18-3
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2-Bromo-3-methoxypyridine Spectrum

2-BROMO-3-METHOXYPYRIDINE(24100-18-3)1HNMR2-BROMO-3-METHOXYPYRIDINE(24100-18-3)FT-IR

24100-18-3 (2-Bromo-3-methoxypyridine) Related Search:

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TIMTEC-BB SBB005633 AKOS BBS-00006021 2-BROMO-3-METHOXYPYRIDINE, 98+% 2-BROMO-3-METHOXYPYRIDINE, PURUM, 97% BROMO-3-METHOXYPYRIDINE Pyridine,2-bromo-3-methoxy- 2-BROMO-3-METHOXYPYRIDI 2-Bromo-3-methoxypyridine > 2-BROMO-3-METHOXYPYRIDINE ISO 9001：2015 REACH 2-Bromo-3-methoxypyridine 24100-18-3 Heterocyclic Building Blocks Halogenated Heterocycles Pyridines Building Blocks blocks Bromides Pyridines Halides Pyridine Heterocyclic Compounds Heterocycles C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Aromatics