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2-BROMO-3-METHOXYPYRIDINE

2-BROMO-3-METHOXYPYRIDINE structure

CAS No.: 24100-18-3

Chemical Name:: 2-BROMO-3-METHOXYPYRIDINE

Synonyms: AKOS BBS-00006021;TIMTEC-BB SBB005633;BROMO-3-METHOXYPYRIDINE;2-BROMO-3-METHOXYPYRIDI;2-BROMO-3-METHOXYPYRIDINE;Pyridine,2-bromo-3-methoxy-;2-Bromo-3-methoxypyridine >2-BROMO-3-METHOXYPYRIDINE, 98+%;2-BROMO-3-METHOXYPYRIDINE, PURUM, 97%;2-BROMO-3-METHOXYPYRIDINE ISO 9001：2015 REACH

CBNumber:: CB4354149

Molecular Formula:: C6H6BrNO

Molecular Weight:: 188.02

MDL Number:: MFCD01570896

MOL File:: 24100-18-3.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:50

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2-BROMO-3-METHOXYPYRIDINE Properties

Melting point	45-49 °C (lit.)
Boiling point	233.4±20.0 °C(Predicted)
Density	1.530±0.06 g/cm3(Predicted)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Dichloromethane
pka	-0.51±0.10(Predicted)
form	Crystalline Powder
color	White to cream
InChI	InChI=1S/C6H6BrNO/c1-9-5-3-2-4-8-6(5)7/h2-4H,1H3
InChIKey	PDOWLYNSFYZIQX-UHFFFAOYSA-N
SMILES	C1(Br)=NC=CC=C1OC
CAS DataBase Reference	24100-18-3(CAS DataBase Reference)
FDA UNII	SQN9M14S1Y
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338+P310

Hazard Codes

Risk Statements

22-37/38-41

Safety Statements

26-39

WGK Germany

HS Code

29333990

NFPA 704

	1
2		0

2-BROMO-3-METHOXYPYRIDINE price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	649716	2-Bromo-3-methoxypyridine 97%	24100-18-3	1g	$31.2	2023-06-20	Buy
Sigma-Aldrich	649716	2-Bromo-3-methoxypyridine 97%	24100-18-3	10g	$278	2023-06-20	Buy
TCI Chemical	B3861	2-Bromo-3-methoxypyridine >98.0%(GC)	24100-18-3	5g	$92	2025-07-31	Buy
TCI Chemical	B3861	2-Bromo-3-methoxypyridine >98.0%(GC)	24100-18-3	25g	$327	2025-07-31	Buy
TRC	B684820	2-Bromo-3-methoxypyridine	24100-18-3	250mg	$140	2021-12-16	Buy

Product number	Packaging	Price	Buy
649716	1g	$31.2	Buy
649716	10g	$278	Buy
B3861	5g	$92	Buy
B3861	25g	$327	Buy
B684820	250mg	$140	Buy

2-BROMO-3-METHOXYPYRIDINE Chemical Properties,Uses,Production

Chemical Properties

2-BROMO-3-METHOXYPYRIDINE is Light yellow Cryst

Uses

2-BROMO-3-METHOXYPYRIDINE is used in the preparation of triazolopyrimidine derivatives and analogs as AXL receptor tyrosine kinase function inhibitors.

Synthesis Reference(s)

Tetrahedron, 42, p. 1475, 1986 DOI: 10.1016/S0040-4020(01)87367-1

Synthesis

6602-32-0

74-88-4

24100-18-3

Under nitrogen protection, sodium hydride (605 mg, 15.1 mmol) was added in batches to ice-cooled methanol (10 mL). After stirring for 20 min, a solution of 2-bromo-3-hydroxypyridine (2.5 g, 14.4 mmol) in dimethylformamide (20 mL) was added to the reaction system. Subsequently, methanol was removed by distillation under reduced pressure and iodomethane (0.94 mL, 15.1 mmol) was added to the residue. The reaction mixture was stirred at room temperature for 3 hours. After completion of the reaction, the mixture was concentrated to dryness and the residue was treated with water (50 mL) and ether (50 mL). The organic layer was separated and washed sequentially with saturated aqueous sodium bicarbonate and brine. The organic phase was dried with anhydrous magnesium sulfate and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate = 8:1) to afford the target compound 2-bromo-3-methoxypyridine (1.51 g, 56% yield) as colorless needle-like crystals. The product was confirmed by 1H-NMR (400 MHz, CDCl3): δ 3.90 (3H, s), 7.12 (1H, m), 7.21 (1H, dd, J = 4.8, 8.0 Hz), 7.97 (1H, m). IR (ATR) showed characteristic absorption peaks: 1556, 1410, 1076, 1049, 788 cm-1. The melting point is 34°C.

References

[1] Chemische Berichte, 1983, vol. 116, # 6, p. 2394 - 2397
[2] Patent: EP1466898, 2004, A1. Location in patent: Page 100
[3] Tetrahedron, 1986, vol. 42, # 5, p. 1475 - 1485
[4] Patent: US2003/212110, 2003, A1
[5] Patent: US6166006, 2000, A

2-BROMO-3-METHOXYPYRIDINE Preparation Products And Raw materials

Raw materials

Methanol 2-Bromo-3-hydroxypyridine Iodomethane Sodium hydride

Preparation Products

5'-hydroxypiroxicam 2-BROMO-5-METHOXYPYRIDINE 2-BROMO-3-METHOXYPYRIDINE-N-OXIDE

2-BROMO-3-METHOXYPYRIDINE Suppliers

Global( 279)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8617732866630	abby@chuanghaibio.com	China	8773	58
Hebei Mujin Biotechnology Co.,Ltd	+8613288715578	sales@hbmojin.com	China	12568	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971	deasea125996@gmail.com	China	2472	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20202	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	12881	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10406	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Mujin Biotechnology Co.,Ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Henan Fengda Chemical Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from 2-BROMO-3-METHOXYPYRIDINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-08	2-BROMO-3-METHOXYPYRIDINE 24100-18-3	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mujin Biotechnology Co.,Ltd
2025-07-25	2-BROMO-3-METHOXYPYRIDINE 24100-18-3	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-06-24	2-BROMO-3-METHOXYPYRIDINE 24100-18-3	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd

2-BROMO-3-METHOXYPYRIDINE
24100-18-3
US $0.00 / KG
99%
Hebei Mujin Biotechnology Co.,Ltd

2-BROMO-3-METHOXYPYRIDINE
24100-18-3
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-BROMO-3-METHOXYPYRIDINE
24100-18-3
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-BROMO-3-METHOXYPYRIDINE Spectrum

2-BROMO-3-METHOXYPYRIDINE(24100-18-3)¹HNMR 2-BROMO-3-METHOXYPYRIDINE(24100-18-3)FT-IR

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TIMTEC-BB SBB005633 2-BROMO-3-METHOXYPYRIDINE AKOS BBS-00006021 2-BROMO-3-METHOXYPYRIDINE, 98+% 2-BROMO-3-METHOXYPYRIDINE, PURUM, 97% BROMO-3-METHOXYPYRIDINE Pyridine,2-bromo-3-methoxy- 2-BROMO-3-METHOXYPYRIDI 2-Bromo-3-methoxypyridine > 2-BROMO-3-METHOXYPYRIDINE ISO 9001：2015 REACH 24100-18-3 Heterocyclic Building Blocks Halogenated Heterocycles Pyridines Building Blocks blocks Bromides Pyridines Halides Pyridine Heterocyclic Compounds Heterocycles C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Aromatics