4'-Methylthioacetophenone
- CAS No.
- 1778-09-2
- Chemical Name:
- 4'-Methylthioacetophenone
- Synonyms
- Ethanone, 1-[4-(methylthio)phenyl]-;4-(METHYLTHIO)ACETOPHENONE;4-METHYLMERCAPTOACETOPHENONE;4-(METHYLTHIO)ACETOPHENONE 99%;1-[4-(METHYLTHIO)PHENYL]ETHANONE;4-(Methyl thio);p-Acetylthioanisole;4'-Methylthioacetoph;Glycerol Impurity 24;4-(ACETYL)THIOANISOLE
- CBNumber:
- CB4454274
- Molecular Formula:
- C9H10OS
- Molecular Weight:
- 166.24
- MDL Number:
- MFCD00039835
- MOL File:
- 1778-09-2.mol
- MSDS File:
- SDS
| Melting point | 80-82 °C(lit.) |
|---|---|
| Boiling point | 135 °C |
| Density | 1.1369 (rough estimate) |
| refractive index | 1.5600 (estimate) |
| Flash point | 135°C/1mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Methanol |
| form | Solid |
| color | White to Off-White |
| BRN | 1860517 |
| InChI | InChI=1S/C9H10OS/c1-7(10)8-3-5-9(11-2)6-4-8/h3-6H,1-2H3 |
| InChIKey | JECUZQLBQKNEMW-UHFFFAOYSA-N |
| SMILES | C(=O)(C1=CC=C(SC)C=C1)C |
| CAS DataBase Reference | 1778-09-2(CAS DataBase Reference) |
| FDA UNII | FN9JM37X2P |
| NIST Chemistry Reference | 4-CH3S-C6H4-COCH3(1778-09-2) |
| EPA Substance Registry System | 4'-(Methylmercapto)acetophenone (1778-09-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29309099 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
4'-Methylthioacetophenone price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 396583 | 4′-(Methylthio)acetophenone 97% | 1778-09-2 | 1g | $26.4 | 2026-04-30 | Buy |
| TCI Chemical | M1672 | 4'-(Methylthio)acetophenone >98.0%(GC) | 1778-09-2 | 5g | $64 | 2026-04-30 | Buy |
| TCI Chemical | M1672 | 4'-(Methylthio)acetophenone >98.0%(GC) | 1778-09-2 | 25g | $186 | 2026-04-30 | Buy |
| Usbiological | 281645 | 4'-(Methylthio)acetophenone Asreported | 1778-09-2 | 10g | $347 | 2026-06-03 | Buy |
| Usbiological | 281645 | 4'-(Methylthio)acetophenone Asreported | 1778-09-2 | 25g | $496 | 2026-06-03 | Buy |
4'-Methylthioacetophenone Chemical Properties,Uses,Production
Chemical Properties
White to light yellow crystal powde
Uses
4′-(Methylthio)acetophenone may be used for the synthesis of Vioxx (Rofecoxib), an non-steroidal anti-inflammatory drug (NSAID). It may be used in the synthesis of (E)-1-[4-(methylsulfanyl)phenyl]-3-phenylprop-2-en-1-one.
Synthesis Reference(s)
Journal of the American Chemical Society, 73, p. 2857, 1951 DOI: 10.1021/ja01150a127
The Journal of Organic Chemistry, 56, p. 5955, 1991 DOI: 10.1021/jo00020a048
General Description
4′-(Methylthio)acetophenone (4-(Methylthio)acetophenone, p-(methylthio) acetophenone, 4-MTAP) is a sulphur containing organic building block. It is a key intermediate in drug synthesis. Its industrial preparation, via Friedel-Crafts acylation reaction in the presence of aluminium chloride as catalyst and acetyl chloride as acylating agent has been reported. It has been prepared by the acetylation reaction of thioanisole with acetic anhydride in the presence of solid acid catalyst.
4'-Methylthioacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Liteng Biotechnology Co., Ltd | 15020019777 18663721413 | rosy@litengpharm.com | China | 1615 | 58 |
| Beijing Nordhuns Chemical Technology Co.,Ltd | 010-84929330 13811281791 | info@nordhuns.com | China | 299 | 58 |
| Shanghai Witofly Chemical Co. ,Ltd. | 02150630626 17717886015 | sales@witofly.com | China | 1864 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Lastest Price from 4'-Methylthioacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | 4"-Methylthioacetophenone
1778-09-2
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2019-07-06 | 4'-Methylthioacetophenone
1778-09-2
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 4"-Methylthioacetophenone
1778-09-2
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 4'-Methylthioacetophenone
1778-09-2
- $7.00
- 99%
- Career Henan Chemical Co
