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Trifluoro-p-tolunitrile

Trifluoro-p-tolunitrile structure

CAS No.: 455-18-5

Chemical Name:: Trifluoro-p-tolunitrile

Synonyms: 4-(TRIFLUOROMETHYL)BENZONITRILE;P-TRIFLUOROMETHYLBENZONITRILE;Benzonitrile, 4-(trifluoromethyl)-;PTF-CN;Trifluoro-p-tolunitr;4-Cyanobenzotrifloride;p-Cyanobenzotrifluoride;4-CYANOBENZOTRIFLUORIDE;trifluoro-p-tolunitrile;Trifluoro-p-toluonitrile

CBNumber:: CB4470085

Molecular Formula:: C8H4F3N

Molecular Weight:: 171.12

MDL Number:: MFCD00001826

MOL File:: 455-18-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:10:40

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Trifluoro-p-tolunitrile Properties

Melting point	39-41 °C(lit.)
Boiling point	80-81 °C20 mm Hg(lit.)
Density	1.278 g/mL at 25 °C(lit.)
refractive index	n20/D 1.4583(lit.)
Flash point	161 °F
storage temp.	Sealed in dry,Room Temperature
Water Solubility	Insoluble in water
solubility	soluble in Chloroform, Methanol
form	powder to lump to clear liquid
color	White or Colorless to Light yellow
Specific Gravity	1.278
Sensitive	Lachrymatory
BRN	2046478
InChI	1S/C8H4F3N/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-4H
InChIKey	DRNJIKRLQJRKMM-UHFFFAOYSA-N
SMILES	FC(F)(F)c1ccc(cc1)C#N
CAS DataBase Reference	455-18-5(CAS DataBase Reference)
FDA UNII	XZK6HN6CLT
NIST Chemistry Reference	4-Trifluoromethylbenzoic acid nitrile(455-18-5)
EPA Substance Registry System	Benzonitrile, 4-(trifluoromethyl)- (455-18-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H228-H302+H312+H332

Precautionary statements

P210-P240-P280-P301+P312-P302+P352+P312-P304+P340+P312

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,F

Risk Statements

20/21/22-11

Safety Statements

36/37-45-36

RIDADR

UN 1325 4.1/PG 2

WGK Germany

Hazard Note

Lachrymatory

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29269095

Storage Class

4.1B - Flammable solid hazardous materials

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Flam. Sol. 1

REACH Registrations

Inactive

Limited Quantities

1.0 Kg (2.2 lbs)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
2		0

Trifluoro-p-tolunitrile price More Price(74)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	196681	4-(Trifluoromethyl)benzonitrile 99%	455-18-5	5g	$28.5	2026-04-30	Buy
Sigma-Aldrich	196681	4-(Trifluoromethyl)benzonitrile 99%	455-18-5	25g	$63.3	2026-04-30	Buy
TCI Chemical	C1005	4-(Trifluoromethyl)benzonitrile >98.0%(GC)	455-18-5	5g	$27	2026-04-30	Buy
TCI Chemical	C1005	4-(Trifluoromethyl)benzonitrile >98.0%(GC)	455-18-5	25g	$45	2026-04-30	Buy
Usbiological	289690	4-(Trifluoromethyl)benzonitrile Asreported	455-18-5	100g	$323	2026-06-03	Buy

Product number	Packaging	Price	Buy
196681	5g	$28.5	Buy
196681	25g	$63.3	Buy
C1005	5g	$27	Buy
C1005	25g	$45	Buy
289690	100g	$323	Buy

Trifluoro-p-tolunitrile Chemical Properties, Uses, Production

Preparation

nitrogen-protected flask, thermometer, and stirrer were installed. 200 mL of acetonitrile, 6.6 g (25 mmol) of triphenylphosphine, and 10 mmol of anhydrous nickel chloride (dried under vacuum at 100 °C with 2.4 g NiCl₂·6H₂O until yellow, requiring approximately 6–9 h) were added. Under nitrogen protection, the mixture was heated to reflux in an oil bath (80–82 °C) and stirred for 10 min until the solution turned dark green. The mixture was cooled to room temperature, and 4.3 g (60 mmol) of zinc powder was added. The reaction proceeded until an orange-yellow precipitate formed. The temperature was then raised to 45 °C, and the reaction proceeded for 0.5 h. 122.4 g (0.68 mol) of p-chlorotrifluorotoluene was added, and the mixture was stirred for 5 min. 44.2 g (0.68 mol) of potassium cyanide was then added, and the solution immediately turned yellow-green. The reaction was continued at this temperature with stirring. Gas chromatography monitoring showed that after 15 h, the conversion rate of p-chlorotrifluorotoluene was 82.7%, the hydrogenated dehalogenated trifluorotoluene was 0.4%, and the biphenyl product 4,4'-ditrifluoromethylbiphenyl was 0.8%. Anhydrous potassium carbonate was added and stirred for 5 min. The mixture was filtered, and the filtrate was an orange-red solution. Vacuum distillation yielded white Trifluoro-p-tolunitrile crystals.

Chemical Properties

white to light yellow crystal powder

Uses

4-(Trifluoromethyl)benzonitrile is used in the synthesis of quinazolines for amidines. Also used in the synthesis of s-transferase p1-1 and cancer cell proliferation.

General Description

4-(Trifluoromethyl)benzonitrile is a key intermediate in the synthesis of fluvoxamine. It participates in nickel-catalyzed arylcyanation reaction of 4-octyne.

Trifluoro-p-tolunitrile Preparation Products And Raw materials

Raw materials

Preparation Products

4-(Trifluoromethyl)-2-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzonitrile 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone 4-(Difluoromethyl)benzonitrile N'-hydroxy-4-(trifluoromethyl)benzenecarboximidamide 1-Methyl-1-(4-trifluoromethylphenyl)ethylamine

4-fluoro-4'-(trifluoromethyl)benzophenone 4-Methyl-1-[4-(trifluoromethyl)phenyl]pentan-1-one

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Trifluoro-p-tolunitrile Suppliers

Global Suppliers ( 458)

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou Baiji Biotechnology Co., LTD	13615701454	616495203@qq.com	China	24	58
Jinan Jinchi Pharmaceutical Technology Co., LTD	15168890063 18888326116	76337143@qq.com	China	64	58
NANJING SUNSHINE BIOTECH CO.,LTD	025-86189919,025-86189929 13814179829	market@sunshine-bio.com	China	48	58
Shandong Dexin Fine Chemical Co., Ltd.	18553366272	3091507995@qq.com	China	278	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81

Supplier	Advantage
Hangzhou Baiji Biotechnology Co., LTD	58
Jinan Jinchi Pharmaceutical Technology Co., LTD	58
NANJING SUNSHINE BIOTECH CO.,LTD	58
Shandong Dexin Fine Chemical Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81

Trifluoro-p-tolunitrile: Synthesis & Application in Agrochemicals
Trifluoro-p-tolunitrile is synthesized via substitution, enabling efficient production of fluvoxamine and high-performance agr....
Jan 27,2026

View Latest Price from Trifluoro-p-tolunitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	Trifluoro-p-tolunitrile 455-18-5	$5.00	1kg	≥98%	200mt/year	Jinan Finer Chemical Co., Ltd
2026-09-11	Trifluoro-p-tolunitrile 455-18-5		1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-20	Trifluoro-p-tolunitrile 455-18-5	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

Trifluoro-p-tolunitrile
455-18-5
$5.00
≥98%
Jinan Finer Chemical Co., Ltd

Trifluoro-p-tolunitrile
455-18-5
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Trifluoro-p-tolunitrile
455-18-5
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Trifluoro-p-tolunitrile Spectrum

Trifluoro-p-tolunitrile(455-18-5)MS Trifluoro-p-tolunitrile(455-18-5)¹HNMR Trifluoro-p-tolunitrile(455-18-5)IR1 Trifluoro-p-tolunitrile(455-18-5)Raman

455-18-5 (Trifluoro-p-tolunitrile) Related Search:

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3-(Trifluoromethyl)benzaldehyde 4-(Trifluoromethyl)benzene-1-sulfonyl chloride 4'-(Trifluoromethyl)acetophenone 2-(Trifluoromethyl)benzaldehyde alpha,alpha,alpha-Trifluoro-o-toluoyl chloride

p-Tolunitrile 3-Aminobenzotrifluoride Trifluoromethanesulfonic acid 4-Nitrobenzonitrile 4-(Trifluoromethyl)cinnamic acid

4-(Trifluoromethyl)benzenesulfonamide 4-(Trifluoromethyl)phenylacetonitrile 4-(Trifluoromethoxy)benzonitrile

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PTF-CN P-TRIFLUOROMETHYLBENZONITRILE PARA-TRIFLUOROMETHYL-BENZONITRILE trifluoro-p-tolunitrile 4-CYANOBENZOTRIFLUORIDE ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLUNITRILE alpha,alpha,alpha-Trifluoro-p-toluonitrile Benzonitrile, 4-(trifluoromethyl)- Benzonitrile, p-(trifluoromethyl)- p-Cyanobenzotrifluoride p-Tolunitrile, alpha,alpha,alpha-trifluoro- 4-Cyanobenzotrifloride alpha,alpha,alpha-trifluoro-4-toluonitrile 4-(TRIFLUOROMETHYL)-PHENYL CYANIDE à,à,à-trifluoro-p-tolunitrile 4-(Trifluoromethyl)benzonitrile98% alpha,alpha,alpha-Trifluor-4-toluonitril p-trifluoromethylbenonitrile 4-(trifluoromethyl)-benzonitril 4-TRIFLUOROMETHYLBENZONITRILE (ALPHA,ALPHA,ALPHA-TRIFLUORO-P-TOLUNITRILE) 4-Trifluormethylbenzonitrile 4-Cyano-α,α,α-trifluorotoluene 4-Trifluoromethylbenzonitrile (alpha,alpha,alpha-Trifluoro-p-tol alpha,alpha,alpha-Trifluoro-p-tolunitrile,99% Trifluoro-p-tolunitr 4-Cyanobenzotrifluoride alpha,alpha,alpha-Trifluoro-p-tolunitrile Alpha-Trifluoro-p-tolunitrile 4-(TrifluoroMethyl)benzonitrile, 97+% 4-Cyanobenzotrifluoride α,α,α-Trifluoro-p-tolunitrile 4-(Trifluoromethyl)benzonitrile> Trifluoromethylphenonitrile Trifluoro-p-toluonitrile 4-(Trifluoromethyl)benzonitrile good supplier,High Quality/low price 455-18-5 4-(Trifluoromethyl)benzonitrile,99% α,α,α-trifluoro-4-toluonitrile 4-(TRIFLUOROMETHYL)BENZONITRILE 455-18-5 135501-67-1 CF3C6H4CN Nitrogen Compounds Organic Building Blocks C8 to C9 Building Blocks Cyanides/Nitriles cyanide Aromatic Nitriles Drug Intermediates Benzotrifluoride Series Fluorine Compounds Nitriles Nitrile bc0001 455-18-5