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4-(Trifluoromethoxy)benzonitrile

4-(Trifluoromethoxy)benzonitrile Structure
4-(Trifluoromethoxy)benzonitrile structure
CAS No.
332-25-2
Chemical Name:
4-(Trifluoromethoxy)benzonitrile
Synonyms
uoromethoxy)benzonitriL;p-trifluoromethoxybenonitrile;p-Cyanotrifluoromethoxybenzene;4-(Trifluoromethoxy)benzonitrile;4-(Trifluoromethoxy)cyanobenzene;4-(Trifluoromethyloxy)benzonitrile;Benzonitrile, 4-(trifluoromethoxy)-;4-(Trifluoromethoxy)benzonitrile 98%;4-(TRIFLUOROMETHOXY)BENZONITRILE 98;For trifluoromethoxy benzene nitrile
CBNumber:
CB5499137
Molecular Formula:
C8H4F3NO
Molecular Weight:
187.12
MDL Number:
MFCD00039474
MOL File:
332-25-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 03:46:48
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4-(Trifluoromethoxy)benzonitrile Properties

Boiling point 192-193 °C(lit.)
Density 1.285 g/mL at 25 °C(lit.)
refractive index n20/D 1.452(lit.)
Flash point 181 °F
storage temp. Inert atmosphere,Room Temperature
form clear liquid
color Colorless to Almost colorless
BRN 2832939
InChI InChI=1S/C8H4F3NO/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-4H
InChIKey XWHIXOMWXCHJPP-UHFFFAOYSA-N
SMILES C(#N)C1=CC=C(OC(F)(F)F)C=C1
CAS DataBase Reference 332-25-2(CAS DataBase Reference)
EPA Substance Registry System Benzonitrile, 4-(trifluoromethoxy)- (332-25-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Exclamation Mark (GHS07)
GHS06,GHS07
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H332-H335-H227-H331
Precautionary statements  P210e-P405-P501a-P261-P280-P305+P351+P338
Hazard Codes  Xn,T,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36/37/39-45
RIDADR  3276
WGK Germany  3
Hazard Note  Toxic
HazardClass  6.1
PackingGroup  III
HS Code  29269090
NFPA 704
2
2 0

4-(Trifluoromethoxy)benzonitrile price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T2292 4-(Trifluoromethoxy)benzonitrile >98.0%(GC) 332-25-2 1g $22 2026-04-30 Buy
TCI Chemical T2292 4-(Trifluoromethoxy)benzonitrile >98.0%(GC) 332-25-2 5g $36 2026-04-30 Buy
Apolloscientific PC7438G 4-(Trifluoromethoxy)benzonitrile 98% 332-25-2 25g $21 2026-06-04 Buy
Apolloscientific PC7438G 4-(Trifluoromethoxy)benzonitrile 98% 332-25-2 100g $74 2026-06-04 Buy
Apolloscientific PC7438G 4-(Trifluoromethoxy)benzonitrile 98% 332-25-2 500g $226 2026-06-04 Buy
Product number Packaging Price Buy
T2292 1g $22 Buy
T2292 5g $36 Buy
PC7438G 25g $21 Buy
PC7438G 100g $74 Buy
PC7438G 500g $226 Buy

4-(Trifluoromethoxy)benzonitrile Chemical Properties, Uses, Production

Chemical Properties

clear light yellow liquid

General Description

4-(Trifluoromethoxy)benzonitrile serves as an intermediate in the synthesis of fluvoxamine.

Synthesis

4-(Trifluoromethoxy)benzyl alcohol

1736-74-9

4-(Trifluoromethoxy)benzonitrile

332-25-2

To a 25 mL Schlenk tube equipped with a magnetic stirrer were sequentially added CuCl (0.05 mmol, 5 mol%), DABCO (0.10 mmol, 10 mol%) and 4-HO-TEMPO (0.05 mmol, 5 mol%). Subsequently, a solution of acetonitrile (2 mL) with 4-trifluoromethoxybenzyl alcohol (1 mmol) and ammonia (25-28%, 3 mmol, 3.0 equiv) was added. The reaction mixture was stirred at room temperature for 24 h under balloon protection. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the mixture was diluted with water and extracted with ethyl acetate. The organic layers were combined and dried with anhydrous magnesium sulfate. After concentration under reduced pressure, the crude product was purified by column chromatography to give p-trifluoromethoxybenzonitrile.

References

[1] Advanced Synthesis and Catalysis, 2014, vol. 356, # 18, p. 3892 - 3896
[2] Chinese Chemical Letters, 2018, vol. 29, # 3, p. 464 - 466

4-(Trifluoromethoxy)benzonitrile Preparation Products And Raw materials

Raw materials

Methanol, 1,1,1-trifluoro-, silver(1+) salt (1:1) 1-Bromo-4-(trifluoromethoxy)benzene 4-(Trifluoromethoxy)benzaldoxime 4-(Trifluoromethoxy)benzyl alcohol Copper(I) Cyanide
Benzenediazonium, 4-cyano-, tetrafluoroborate(1-) 4-Hydroxy-TEMPO Copper(I) chloride Acetonitrile Triethylenediamine

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Preparation Products

4-(Trifluoromethoxy)benzoic acid 3-Methyl-2-oxazolidone 2-Methyl-1[4-(trifluoromethoxy)phenyl] propan-1-one 3,4-dimethyl-5-phenyl-oxazolidin-2-one 1-[4-(Trifluoromethoxy)phenyl]cyclopropan-1-amine
4-(Trifluoromethoxy)thiobenzamide

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4-(Trifluoromethoxy)benzonitrile Suppliers

Global Suppliers ( 227)
Supplier Tel Email Country ProdList Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Supplier Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 64
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60

View Latest Price from 4-(Trifluoromethoxy)benzonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(Trifluoromethoxy)benzonitrile pictures 2019-07-06 4-(Trifluoromethoxy)benzonitrile
332-25-2
 $1.00 1KG 99% Career Henan Chemical Co

4-(Trifluoromethoxy)benzonitrile Spectrum

4-(Trifluoromethoxy)benzonitrile(332-25-2)MS4-(Trifluoromethoxy)benzonitrile(332-25-2)1HNMR4-(Trifluoromethoxy)benzonitrile(332-25-2)IR14-(Trifluoromethoxy)benzonitrile(332-25-2)Raman

332-25-2 (4-(Trifluoromethoxy)benzonitrile) Related Search:

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4-Methoxybenzoic acid 3-(Methoxymethoxy)benzaldehyde Trifluoro-p-tolunitrile

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4-(trifluoromethoxy)benzonitrile(SALTDATA: FREE) For trifluoromethoxy benzene nitrile 4-(TRIFLUOROMETHOXY)BENZONITRILE 98 4-(Trifluoromethoxy)benzonitrile 98% p-trifluoromethoxybenonitrile 4-(Trifluoromethoxy)benzonitrile p-Cyanotrifluoromethoxybenzene Benzonitrile, 4-(trifluoromethoxy)- 4-(Trifluoromethyloxy)benzonitrile 4-(Trifluoromethoxy)cyanobenzene uoromethoxy)benzonitriL 332-25-2 332-25-9 CF3OC6H4CN Trifluoroanisole series Aromatic Nitriles Building Blocks C8 to C9 Chemical Synthesis Nitrogen Compounds Organic Building Blocks Nitrile C8 to C9 Cyanides/Nitriles Nitrogen Compounds