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5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone Structure
5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone structure
CAS No.
61718-80-7
Chemical Name:
5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone
Synonyms
Fluvoxketone;Fluvoxketone USP/EP/BP;Fluvoxamine Impurity 8;Fluvoxamine EP Impurity D;5-Methoxy-1-[4-(Trifluoromethy;Fluvoxamine Maleate Impurity D;FluvoxaMine interMediate product;Fluvoxamine maleate Intermediate;Fluvoxamine Maleate EP Impurity D;5-Methoxy-1-[4-(trifluoromethyl)phe
CBNumber:
CB8462372
Molecular Formula:
C13H15F3O2
Molecular Weight:
260.25
MDL Number:
MFCD06658173
MOL File:
61718-80-7.mol
MSDS File:
SDS
Last updated:2026-05-28 03:27:10
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5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone Properties

Melting point 50-52°C
Boiling point 318.7±42.0 °C(Predicted)
Density 1.147±0.06 g/cm3(Predicted)
vapor pressure 0Pa at 20℃
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Methanol (Slightly)
form solid
Appearance White to off-white Solid
Water Solubility 74.36mg/L at 20℃
Major Application pharmaceutical
pharmaceutical small molecule
InChI InChI=1S/C13H15F3O2/c1-18-9-3-2-4-12(17)10-5-7-11(8-6-10)13(14,15)16/h5-8H,2-4,9H2,1H3
InChIKey VYKSRLDHXQURKA-UHFFFAOYSA-N
SMILES C(C1=CC=C(C(F)(F)F)C=C1)(=O)CCCCOC
LogP 3.3
CAS DataBase Reference 61718-80-7(CAS DataBase Reference)
FDA UNII 8D8A03845N
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Environment (GHS09)
GHS09
Signal word  Warning
Hazard statements  H411
Precautionary statements  P273-P391-P501
RIDADR  UN 3077 9 / PGIII
WGK Germany  WGK 2
HS Code  2914500090
Storage Class 13 - Non Combustible Solids
Hazard Classifications Aquatic Chronic 2
REACH Registrations Active

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000916 Fluvoxamine impurity D European Pharmacopoeia (EP) Reference Standard 61718-80-7 10 mg $127 2026-04-30 Buy
Sigma-Aldrich BP1190 Fluvoxamine impurity D British Pharmacopoeia (BP) Reference Standard 61718-80-7 25MG $238 2026-04-30 Buy
Sigma-Aldrich Y0000916 Fluvoxamine impurity D European Pharmacopoeia (EP) Reference Standard 61718-80-7 y0000916 $150 2024-03-01 Buy
TRC TRC-F603700-250MG Fluvoxketone 61718-80-7 250mg $241 2026-06-03 Buy
TRC TRC-F603700-100MG Fluvoxketone 61718-80-7 100mg $173 2026-06-03 Buy
Product number Packaging Price Buy
Y0000916 10 mg $127 Buy
BP1190 25MG $238 Buy
Y0000916 y0000916 $150 Buy
TRC-F603700-250MG 250mg $241 Buy
TRC-F603700-100MG 100mg $173 Buy

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone Chemical Properties, Uses, Production

Chemical Properties

White Solid

Uses

Fluvoxamine intermediate

Flammability and Explosibility

Non flammable

Synthesis

4-Chlorobutyl methyl ether

17913-18-7

Methyl 4-trifluoromethylbenzoate

2967-66-0

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone

61718-80-7

Under nitrogen atmosphere, 1500 mL of anhydrous tetrahydrofuran and 108 g of magnesium shavings were added to the reaction flask, followed by a few drops of iodomethane as initiator. The reaction system was warmed to 75 °C and stirred until the magnesium shavings were completely dissolved. Slowly 602.1 g of 1-chloro-4-methoxybutane was added dropwise, and after completion of the dropwise addition, the reaction was kept at a constant temperature for 13 hours. After the reaction was complete, cooled to room temperature, then 45.88 g of methyl 4-(trifluoromethyl)benzoate prepared in step 1 was slowly added dropwise at a controlled rate of 5 g per min. After completion of the dropwise addition, the reaction mixture was heated to 70 °C and maintained at a constant temperature for 4-6 hours. After the reaction was complete, it was cooled to room temperature and acidified by slowly adding ice hydrochloric acid to the reaction solution. The reaction mixture was extracted with tetrahydrofuran and the organic phases were combined and concentrated. The aqueous phase was further extracted with dichloromethane and the organic phase was combined with the previously concentrated tetrahydrofuran phase. The combined organic phases were dried with anhydrous sodium sulfate, filtered and concentrated to give 152.36 g of 1-[4-(trifluoromethyl)phenyl]-5-methoxyvalerophenone in 90.5% yield.

References

[1] Patent: CN108191630, 2018, A. Location in patent: Paragraph 0024; 0025; 0027

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone synthesis

17913-18-7
2967-66-0
61718-80-7
Synthesis of 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone from 4-Chlorobutyl methyl ether and Methyl 4-trifluoromethylbenzoate

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone Preparation Products And Raw materials

Raw materials

Benzotrifluoride Aluminum chloride Carbon disulfide Sodium Methoxide Hydrochloric acid
Dichloromethane Methanol 5-Chlorovaleronitrile Methyl 4-trifluoromethylbenzoate 1-Pentanone-5-methoxy-1-[4-(trifluoromethyl)phenyl]-oxime
1-Bromo-4-methoxybutane 4-Chlorobutyl methyl ether Trifluoro-p-tolunitrile

1of3

Preparation Products

Fluvoxamine maleate

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone Suppliers

Global Suppliers ( 241)
Supplier Tel Email Country ProdList Advantage
Hangzhou Minsuo Technology Co., Ltd. 571-88199336 18957129209 309645123@qq.com China 55 64
Qingdao and Fine Chemical Co., Ltd. - 0532-66915948 sxq@unionfinechem.com China 46 62
ZHUHAI HRD PHARMACEUTICAL CO., LTD. 7737188 13326687259 sales@hrdpharm.com China 141 58
Shandong Risen-Sun Pharmaceutical Co., Ltd. +86-0538-8923092 13958575904 risensun-sales@jewim.com.cn China 43 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Enantiotech Corporation Ltd 760-85282375 15900088539 sale02@enantiotech.com China 84 55
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Supplier Advantage
Hangzhou Minsuo Technology Co., Ltd. 64
Qingdao and Fine Chemical Co., Ltd. - 62
ZHUHAI HRD PHARMACEUTICAL CO., LTD. 58
Shandong Risen-Sun Pharmaceutical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Enantiotech Corporation Ltd 55
Adamas Reagent, Ltd. 59
Shanghai Longsheng chemical Co.,Ltd. 59

View Latest Price from 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone pictures 2026-06-30 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone
61718-80-7
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone pictures 2026-04-09 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone
61718-80-7
 1KG Ton 99%+ 2 tons/month ZHUHAI HRD PHARMACEUTICAL CO., LTD.
5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone pictures 2020-01-10 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone
61718-80-7
 $7.00 1KG 99% 100KG Career Henan Chemical Co

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone Spectrum

5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone(61718-80-7)1HNMR5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone(61718-80-7)FT-IR

61718-80-7 (5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone) Related Search:

Chlorodimethylphenylsilane Mesotrione 4-Methoxyphenylacetone 4-Methyl-2-pentanone Methyl cyclopentenolone
Diphenylcyclopropenone Phenyl valerate Fluvoxamine maleate 5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone oxime Phenylacetic acid
Valerophenone Voriconazole Bromoethane Fluvoxamine 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone-(E)-O-(2-aminoethyl]oxime Maleic Acid Monoamide
Ethyl 5-oxo-5-(4-trifluoromethylphenyl)valerate 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone 4-(5,5-Dimethyl-1,3-dioxan-2-yl)-4'-trifluoromethylbutyrophenone

1of4

(E)-5-METHOXY-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-PENTANONE 5-METHOXY-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-PENTANONE (4-METHOXYBUTYL)(4-TRIFLUOROMETHYLPHENYL)METHANONE 1-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]- 5-Methoxy-4''-(trifluoromethyl)-valerophenone 5-METHOXY-1-[4-(TRIFLUOROMETHYL)PHENYL]-1-PENTANONE (MECO) (FLUVOXAMINE INTERMEDIATE) 5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone(MECO) 5-Methoxy-1-(4-Trifluoromethylphenyl)Pentanone 5-Methoxy-1-[4-(Trifluoromethy 6-(1-bromoethane)-4-chloro-5-fluoro pyrimidine (intermediate of voriconazole) Fluvoxamine Maleate EP Impurity D 4-trifluoromethyl-5-methoxy-valerophenone 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone ,98% FluvoxaMine interMediate product EP IMpurity D 5-Methoxy-1-[4-(trifluoroMethyl)phenyl]-1-pentanone 5-Methoxy-1-(4-trifluoroMethyl-phenyl)-pentan-1-one, (4-Methoxybutyl)(4-trifluoroMethylphenyl)Methanone, 5-Methoxy-4'-trifluoroMethylvalerophenone, 4-trifluoroMethylvalerophenone 5-METHOXY-1-(4-TRIFLUOROMETHYI)PHENYI)-1-PENTANONE 5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one, 4-(5-Methoxypentanoyl)benzotrifluoride 5-Methoxy-1-[4-(trifluoromethyl)phenly]-1-pentanone Fluvoxamine Impurity 4 (Fluvoxamine EP Impurity D) Fluvoxamine EP Impurity D 5-Methoxy-1-[4-(trifluoromethyl)phe Fluvoxketone USP/EP/BP 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone USP/EP/BP Fluvoxamine maleate Intermediate Fluvoxamine EP Impurity D (Fluvoxamine Valerophenone analog/ Fluvoxketone) 61718-80-7 5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone Fluvoxamine Impurity 8 Fluvoxamine Maleate Impurity D 5-methoxy-4'-(trifluoromethyl)valerophenone 5-Methoxy-1-[4-(Trifluoromethyl)Phenyl]Pentan-1-One 5--1-[4-()]-1- Impurity D of Fluvoxamine Maleate (Fluvoxamine Ketone Impurity IX) Fluvoxketone 61718-80-7 C13H15F3O2 Fluvoxamine Aromatics Intermediates Intermediates & Fine Chemicals Pharmaceuticals