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ChemicalBook >> CAS DataBase List >>(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine Structure
(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine structure
CAS No.
500997-69-3
Chemical Name:
(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine
Synonyms
(R)-SIPHOS-PE;(S)-SIPHOS-PE;(RA,R,R)-SIPHOS-PE;(R)-SIPHOS-PE 97%;(R)-SIPHOS-PE;(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE;1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE;N-DI[(R)-1-PHENYLETHYL]-[(S)-1,1'-SPIROBIINDANE-7,7'-DIYL]-PHOSPHORAMIDITE;N-DI[(R)-1-PHENYLETHYL]-[(R)-1,1'-SPIROBIINDANE-7,7'-DIYL]-PHOSPHORAMIDITE;N-Di[(R)-1-phenylethyl]-[(R)-1,1'-spirobiindane-7,7'-diyl]-phosphoramidite ,98%
CBNumber:
CB4471613
Molecular Formula:
C33H32NO2P
Molecular Weight:
505.59
MDL Number:
MFCD08459342
MOL File:
500997-69-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:52:50
Request For Quotation

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine Properties

Melting point 98-100°C
alpha +300° (c 1.0, CH2Cl2)
Boiling point 617.8±65.0 °C(Predicted)
storage temp. -20°C
pka 0.40±0.20(Predicted)
form solid
color white
optical activity [α]22/D +337°, c = 1 in chloroform
Sensitive moisture sensitive
InChIKey ZXLQLIDJAURBDD-HRPAVAKOSA-N
UNSPSC Code 12352005

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36/37
WGK Germany  3
Storage Class 13 - Non Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 700770 (R)-SIPHOS-PE 97% 500997-69-3 50mg $190 2022-05-15 Buy
Strem Chemicals 15-5162 (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine, min. 98% (R)-SIPHOS-PE min.98% 500997-69-3 100mg $197 2026-04-30 Buy
Strem Chemicals 15-5162 (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine, min. 98% (R)-SIPHOS-PE min.98% 500997-69-3 500mg $776 2026-04-30 Buy
aablocks AA00DCK7 (11aR)-10,11,12,13-Tetrahydro-N,N-bis[(1R)-1-phenylethyl]diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine 98% 500997-69-3 50mg $57 2026-05-28 Buy
aablocks AA00DCK7 (11aR)-10,11,12,13-Tetrahydro-N,N-bis[(1R)-1-phenylethyl]diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine 95% 500997-69-3 100mg $68 2026-05-28 Buy
Product number Packaging Price Buy
700770 50mg $190 Buy
15-5162 100mg $197 Buy
15-5162 500mg $776 Buy
AA00DCK7 50mg $57 Buy
AA00DCK7 100mg $68 Buy

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine Chemical Properties, Uses, Production

Reaction

  1. Chiral ligands for copper-catalyzed asymmetric allylic alkylation with dialkylzincs.
  2. Chiral ligands for copper-catalyzed asymmetric conjugate addition of diethylzinc to enones.
  3. Chiral ligands for palladium-catalyzed asymmetric hydrosilylation of styrenes
  4. Chiral ligands for copper-catalyzed asymmetric ring-opening of oxabicyclic alkenes with Grignard reagents.
  5. Chiral ligands for nickel-catalyzed asymmetric hydrovinylation of α-alkyl vinylarenes.
  6. Chiral ligands for iridium-catalyzed asymmetric hydrogenation of cyclic enamines.
  7. Chiral ligands for iridium-catalyzed asymmetric hydrogenation of cyclic imines.
  8. Chiral ligands for gold-catalyzed asymmetric [2 + 2] cycloaddition reaction.
  9. Chiral ligands for rhodium-catalyzed asymmetric hydroacylation of salicylaldehydes to homoallylic sulfides.
  10. Chiral ligands for palladium-catalyzed asymmetric carboamination reactions. 
Reactions of 500997-69-3_1
Reactions of 500997-69-3_2
Reactions of 500997-69-3_3
Reactions of 500997-69-3_4

Uses

(R)-SIPHOS-PE can be used as:

  • A catalyst in the preparation of tricyclic alkaloid (+)-aphanorphine via asymmetric carboamination and FriedelCrafts reaction.
  • A ligand in the synthesis of chiral ketones via hydroacylation of olefins using salicylaldehyde derivatives.
  • A ligand in the enantioselective synthesis of substituted pyrrolidine derivatives via Pd-catalyzed alkene aminoarylation reactions.

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine Preparation Products And Raw materials

Raw materials

Calcium hydride Benzyl chloride (R,R)-(+)-Bis(alpha-methylbenzyl)amine hydrochloride Ethanol Acetone
Sodium bromide Methanesulfonic acid Hydrogen peroxide Sodium chloride Toluene
N,N-Diisopropylethylamine Nickel (R,R)-(+)-Bis(alpha-methylbenzyl)amine hydrochloride Cinchonidine Triethylamine
Boron tribromide Palladium 3-Hydroxybenzaldehyde Phosphorus trichloride (R)-1,1'-Spirobiindane-7,7'-diol
Tetrahydrofuran Ethyl acetate Hydrochloric acid Sodium bicarbonate Hydrogen
Dichloromethane Sodium hydroxide Petroleum ether n-Butyllithium

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Preparation Products

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine Suppliers

Global Suppliers ( 51)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Tianjin Derchemist Science & Technology Co., Ltd. 22-58627059 13920586291 zdcomcon@126.com China 4094 50
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai Chiral bio-compound co., Ltd. 021-5068 3667/17749785980/1029026415; 17749785980 1029026415@qq.com China 4501 58
ShangHai Angti Biotechnology Co., Ltd. 13764913901 info@angtibio.com China 4976 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Shanghai SuperLan Chemcial Technique Centre 0-2022843681 15618226720 chaolaichem@foxmail.com China 9996 58
LaaJoo 021-60702684 18516024827 huang.jiayi@sinocompound.com China 2280 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Tianjin Derchemist Science & Technology Co., Ltd. 50
Bide Pharmatech Ltd. 60
Sigma-Aldrich 80
Shanghai Chiral bio-compound co., Ltd. 58
ShangHai Angti Biotechnology Co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
Shanghai SuperLan Chemcial Technique Centre 58
LaaJoo 58

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine Spectrum

(11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE(500997-69-3)1HNMR

500997-69-3 ((11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine) Related Search:

(11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine (R,R)-(+)-Bis(alpha-methylbenzyl)amine hydrochloride (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-dimethylamine 3a,4,7,7a-Tetrahydroindene
(11aR)-10,11,12,13-tetrahydro-N,N-bis[(1S)-1-phenylethyl]-Diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-aMine

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(11AS)-(-)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE:1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1-PHENYLETHYL]AMINE (S)-SIPHOS-PE (R)-SIPHOS-PE N-DI[(R)-1-PHENYLETHYL]-[(R)-1,1'-SPIROBIINDANE-7,7'-DIYL]-PHOSPHORAMIDITE N-DI[(R)-1-PHENYLETHYL]-[(S)-1,1'-SPIROBIINDANE-7,7'-DIYL]-PHOSPHORAMIDITE (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine,min.98%(R)-SIPHOS-PE N-Di[(R)-1-phenylethyl]-[(R)-1,1'-spirobiindane-7,7'-diyl]-phosphoramidite ,98% (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine (11aR)-10,11,12,13-tetrahydro-N,N-bis[(1R)-1-phenylethyl]-Diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-aMine (R)-SIPHOS-PE 97% 1',7'-FG][1,3,2]DIOXAPHOSPHOCIN-5-BIS(R)-1PHENYLETHYL]AMINE (11aR)-10,11,12,13-Tetrahydro-N,N-bis[(1R)-1-phenylethyl]-diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine,99%e.e. (RA,R,R)-SIPHOS-PE N,N-bis[(1R)-1-phenylethyl]-4,5,6,7-tetrahydroiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine (11AR)-(+)-10,11,12,13-TETRAHYDRODIINDENO[7,1-DE Diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine,10,11,12,13-tetrahydro-N,N-bis[(1R)-1-phenylethyl]-, (11aR)- (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1′,7′-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine,N-Di[(R)-1-phenylethyl]-[(R)-1,1′-spirobiindane-7,7′-diyl]-phosphoramidite (R)-SIPHOS-PE,(R,R,R)-SIPHO,N-Di[(R)-1-phenylethyl]-[(R)-1,1′-spirobiindane-7,7′-diyl]-phosphoramidite (11aR)-10,11,12,13-Tetrahydro-N,N-bis[(1R)-1-phenylethyl]diindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-amine (R)-SIPHOS-PE (R)-N,N-bis((R)-1-phenylethyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine N,N-bis((S)-1-phenylethyl)-4,5,6,7-tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-12-amine (11aR)-(+)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1',7'-fg][1,3,2]dioxaphosphocin-5-bis(R)-1phenylethyl]amine 500997-69-3 Chiral Phosphine Chiral Spiro Ligand CPN