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3-Methyl-5-(trifluoromethyl)pyrazole

3-Methyl-5-(trifluoromethyl)pyrazole structure

CAS No.: 10010-93-2

Chemical Name:: 3-Methyl-5-(trifluoromethyl)pyrazole

Synonyms: C5H5F3N2;AKOS B014453;AKOS PAO-1253;AKOS PAO-1201;AKOS BBS-00002817;BUTTPARK 76\07-66;BUTTPARK 29\08-72;CBI-BB ZERO/006128;ART-CHEM-BB B014453;TIMTEC-BB SBB004075

CBNumber:: CB4737458

Molecular Formula:: C5H5F3N2

Molecular Weight:: 150.1

MDL Number:: MFCD00829309

MOL File:: 10010-93-2.mol

MSDS File:: SDS

Last updated:2026-09-12 18:52:57

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3-Methyl-5-(trifluoromethyl)pyrazole Properties

Melting point	88-90 °C(lit.)
Boiling point	187℃
Density	1.355
Flash point	67℃
storage temp.	Inert atmosphere,Room Temperature
pka	11.12±0.10(Predicted)
form	Powder
color	White
InChI	InChI=1S/C5H5F3N2/c1-3-2-4(10-9-3)5(6,7)8/h2H,1H3,(H,9,10)
InChIKey	DLCHCAYDSKIFIN-UHFFFAOYSA-N
SMILES	N1C(C(F)(F)F)=CC(C)=N1
CAS DataBase Reference	10010-93-2(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280a-P304+P340-P405-P501a-P261-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

3-Methyl-5-(trifluoromethyl)pyrazole price More Price(72)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2032	3-Methyl-5-(trifluoromethyl)pyrazole >98.0%(GC)	10010-93-2	1g	$31	2026-04-30	Buy
TCI Chemical	M2032	3-Methyl-5-(trifluoromethyl)pyrazole >98.0%(GC)	10010-93-2	5g	$98	2026-04-30	Buy
Apolloscientific	PC448028	5-Methyl-3-(trifluoromethyl)-1H-pyrazole >98%	10010-93-2	5g	$21	2026-06-04	Buy
Apolloscientific	PC448028	5-Methyl-3-(trifluoromethyl)-1H-pyrazole >98%	10010-93-2	25g	$41	2026-06-04	Buy
Apolloscientific	PC448028	5-Methyl-3-(trifluoromethyl)-1H-pyrazole >98%	10010-93-2	100g	$158	2026-06-04	Buy

Product number	Packaging	Price	Buy
M2032	1g	$31	Buy
M2032	5g	$98	Buy
PC448028	5g	$21	Buy
PC448028	25g	$41	Buy
PC448028	100g	$158	Buy

3-Methyl-5-(trifluoromethyl)pyrazole Chemical Properties,Uses,Production

Chemical Properties

White to orange solid

Uses

3-Methyl-5-(trifluoromethyl)pyrazole is a reagent used in the preparation of (fluoromethyl)pyrazole via microwave-assisted Stille coupling.

Definition

ChEBI: 3-Methyl-5-(trifluoromethyl)-1H-pyrazole is a member of pyrazoles.

General Description

3-Methyl-5-(trifluoromethyl)pyrazole is a pyrazole derivative. It has been reported to be synthesized from 3-methyl-5-trifluoromethyl-1H-pyrazole.

Synthesis

367-57-7

10010-93-2

Example 127: Preparation of 5-methyl-3-trifluoromethyl-1H-pyrazole Hydrazine hydrate (945 μl, 30 mmol) was slowly added to a solution of 1,1,1-trifluoro-2,4-pentanedione (4.62 g, 30 mmol) in methanol (20 ml) at 0 °C. The reaction mixture was gradually warmed up to room temperature and stirred at that temperature for 16 hours. After completion of the reaction, the solvent was removed by concentration under reduced pressure to give 5-methyl-3-trifluoromethyl-1H-pyrazole as a yellow solid (4.5 g, 95% yield). 1H-NMR (400 MHz, CDCl3): δ 2.35 (s, 3H, CH3), 6.32 (s, 1H, CH), 9.88 (bs, 1H, NH) ppm.

References

[1] Patent: WO2007/71900, 2007, A1. Location in patent: Page/Page column 88-89
[2] Tetrahedron Letters, 2016, vol. 57, # 14, p. 1555 - 1559
[3] Tetrahedron Letters, 2014, vol. 55, # 52, p. 7198 - 7202
[4] Patent: WO2013/6792, 2013, A1. Location in patent: Paragraph 0149
[5] Journal of the American Chemical Society, 1998, vol. 120, # 44, p. 11408 - 11418

3-Methyl-5-(trifluoromethyl)pyrazole synthesis

Synthesis of 3-Methyl-5-(trifluoromethyl)pyrazole from 1,1,1-Trifluoro-2,4-pentanedione

3-Methyl-5-(trifluoromethyl)pyrazole Preparation Products And Raw materials

Raw materials

Hydrazinium hydroxide solution 1,1,1-Trifluoro-2,4-pentanedione Methanol HYDRAZINE Iodomethane

Preparation Products

3-Methyl-5-(trifluoromethyl)pyrazole 5-Methyl-1H-pyrazole-3-carboxylic acid Pyrazole

3-Methyl-5-(trifluoromethyl)pyrazole Suppliers

Global( 259)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Baisley Pharmaceutical Technology Co., Ltd.	021-15995002467 15995002467	chen_shuming@126.com	China	155	58
Haimen DsHare Pharmaceutical Technology Co., Ltd.	+86-0513-68050135 13962878782	zhuwdsh@126.com	China	155	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	13611835272 13611835272	mmwang@sunwaypharm.com	China	44090	58
Dancheng Huatai Biotechnology Co., Ltd.	13482210809 13482210809	hli@3wpharm.com	China	357	58
Jinan Langhua Chemical Co., Ltd	0531-85906691 18660816586	325912681@qq.com	China	212	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
Shanghai Baisley Pharmaceutical Technology Co., Ltd.	58
Haimen DsHare Pharmaceutical Technology Co., Ltd.	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	58
Dancheng Huatai Biotechnology Co., Ltd.	58
Jinan Langhua Chemical Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61

View Lastest Price from 3-Methyl-5-(trifluoromethyl)pyrazole manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	5-methyl-3-(trifluoromethyl)pyrazole 10010-93-2	$2.20-8.80	1kg	99%min	1000kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2025-06-27	3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 10010-93-2		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2025-06-20	3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 10010-93-2	$10.00-30.00	1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.

5-methyl-3-(trifluoromethyl)pyrazole
10010-93-2
$2.20-8.80
99%min
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE
10010-93-2
99%
Hebei Chuanghai Biotechnology Co., Ltd

3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE
10010-93-2
$10.00-30.00
0.99
Hebei Yanxi Chemical Co., Ltd.

3-Methyl-5-(trifluoromethyl)pyrazole Spectrum

3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE(10010-93-2)¹HNMR 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE(10010-93-2)IR

10010-93-2(3-Methyl-5-(trifluoromethyl)pyrazole)Related Search:

2-[1-Methyl-3-(trifluoromethyl)pyrazol-5-yl]-thiophene-5-carboxylic acid 2-[1-Methyl-5-(trifluoromethyl)pyrazol-3-yl]-thiophene-5-sulfonyl chloride 3-(4-Bromo-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-propionic acid 4-Bromo-1-methyl-3-(trifluoromethyl)-1H-pyrazole Ethyl 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylate

1-Methyl-3-(trifluoromethyl)-1H-pyrazol-5-ol 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride 4-Bromo-5-methyl-3-trifluoromethylpyrazole 5-Chloro-1-methyl-3-(trifluoromethyl)pyrazole-4-carboxaldehyde 1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-ol

2-[1-Methyl-3-(trifluoromethyl)pyrazol-5-yl]-thiophene-5-carboxaldehyde 4-Bromo-3-methyl-5-(trifluoromethyl)-1H-pyrazole 5-[1-Methyl-3-(trifluoromethyl)pyrazol-5-yl]thiophene2-sulfonyl chloride 1-Acetyl-4-chloro-3(5)-trifluoromethyl-5(3)-(phenyl)pyrazole 1-Acetyl-4-bromo-3(5)-trifluoromethyl-5(3)-(methyl)pyrazole

2-[1-Methyl-5-(trifluoromethyl)pyrazol-3-yl]-thiophene-5-carboxaldehyde 5-[1-Methyl-3-(trifluoromethyl)pyrazol-5-yl]-thiophene-2-sulfonamide 1-Acetyl-3,5-bis(trifluoromethyl)pyrazole

1of4

TIMTEC-BB SBB004075 1H-Pyrazole,3-methyl-5-(trifluoromethyl)- CBI-BB ZERO/006128 BUTTPARK 29\08-72 BUTTPARK 76\07-66 ART-CHEM-BB B014453 3-TRIFLUOROMETHYL-5-(METHYL)PYRAZOLE 3-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE 5-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE AKOS B014453 AKOS BBS-00002817 AKOS PAO-1253 AKOS PAO-1201 Pyrazole, 3(or 5)-methyl-5(or 3)-(trifluoromethyl)- Pyrazole, 3-methyl-5-(trifluoromethyl)- 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 99% 3-Methyl-5-trifluoromethyl-1H-pyrazole ,97% 3-methyl-5-(trifluoromethyl)-1H-pyrazole(SALTDATA: FREE) 5(3)-Methyl-3(5)-(trifluoroMethyl)pyrazole 5-(trifluoromethyl)-3-methyl-1H-pyrazole 3-Methyl-5-(trifluoromethyl)pyrazole> TIANFU-CHEM 3-METHYL-5-(TRIFLUOROMETHYL)PYRAZOLE 3-Methyl-5-(trifluoromethyl)pyrazole, 99% 423-Methyl-5-trifluoroMethylpyrazole C5H5F3N2 3-Methyl-5-(trifluoromethyl)pyrazole 10010-93-2 Pyrazoles Pyrazole series Heterocyclic Compounds Building Blocks Heterocyclic Building Blocks Pyrazoles blocks FluoroCompounds Heterocycles