4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
- CAS No.
- 20870-77-3
- Chemical Name:
- 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
- Synonyms
- AKOS 207-07;4-CHLOROOXINDOLE;4-CHLORO-2-OXINDOLE;4-Chloro-2-oxoindole;4-chloroindolin-2-one;4-Chloroindoline-2-one;4-Chloro-1H-indol-2(3H)-one;4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE;4-CHLORO-1,3-DIHYDRO-2H-INDOL-2-ONE;4-chloro-2,3-dihydro-1H-indol-2-one
- CBNumber:
- CB4740285
- Molecular Formula:
- C8H6ClNO
- Molecular Weight:
- 167.59
- MDL Number:
- MFCD03787567
- MOL File:
- 20870-77-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 206-208° |
|---|---|
| Boiling point | 340.3±42.0 °C(Predicted) |
| Density | 1.362±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | powder |
| pka | 13.27±0.20(Predicted) |
| color | yellow |
| InChI | InChI=1S/C8H6ClNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11) |
| InChIKey | XNSPDJAXCBZCRV-UHFFFAOYSA-N |
| SMILES | N1C2=C(C(Cl)=CC=C2)CC1=O |
| CAS DataBase Reference | 20870-77-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi |
| HazardClass | IRRITANT |
| HS Code | 2933790090 |
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Chem-Impex | 17482 | 4-Chloro-1,3-dihydroindol-2-one ≥98%(HPLC) | 20870-77-3 | 1G | $20 | 2026-05-19 | Buy |
| Chem-Impex | 17482 | 4-Chloro-1,3-dihydroindol-2-one ≥98%(HPLC) | 20870-77-3 | 5G | $45 | 2026-05-19 | Buy |
| Chem-Impex | 17482 | 4-Chloro-1,3-dihydroindol-2-one ≥98%(HPLC) | 20870-77-3 | 25G | $160 | 2026-05-19 | Buy |
| Chem-Impex | 17482 | 4-Chloro-1,3-dihydroindol-2-one ≥98%(HPLC) | 20870-77-3 | 100G | $620 | 2026-05-19 | Buy |
| Matrix Scientific | 044887 | 4-Chloro-1,3-dihydro-2H-indol-2-one | 20870-77-3 | 5.00g | $39 | 2026-05-18 | Buy |
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Chemical Properties,Uses,Production
Synthesis
6344-05-4
20870-77-3
The general procedure for the synthesis of 4-chloro-2-oxoindole (4-chloroindolone) from 4-chloroindoline-2,3-dione was as follows: titanium tetrachloride (TiCl4) (0.7 mL, 6 mmol) was slowly added to a stirring suspension of zinc powder (0.78 g, 12 mmol) in freshly distilled anhydrous THF (15 mL) at room temperature and under dry nitrogen atmosphere. After addition, the mixture was refluxed for 2 hours. After the formed suspension of low-valent titanium reagent was cooled, a THF (10 mL) solution of indigo red or its derivative (2 mmol) was added dropwise. The reaction mixture was stirred at room temperature for about 5 min under nitrogen protection. After confirming the completion of the reaction by thin layer chromatography (TLC) analysis, the reaction was quenched with 3% hydrochloric acid (15 mL) and subsequently extracted with chloroform (3 x 50 mL). The organic phases were combined, washed with water (3 x 50 mL) and dried over anhydrous sodium sulfate. After concentration of the solvent under reduced pressure, the crude product was purified by column chromatography (petroleum ether/ethyl acetate = 5:1) to afford the target compound 4-chloro-2-oxindole (4-chloroindolone).
References
[1] Tetrahedron Letters, 2014, vol. 55, # 14, p. 2238 - 2242
4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tuolei Chemical Reagents Co., Ltd. | 86-021-50318510 | China | 67 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
View Lastest Price from 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-06-02 | 4-Chloro-2-oxindole 4-Chloro-1,3-dihydro-indol-2-one in stock Factory
20870-77-3
|
$1.00 | 1kg | High quality purified Factory in China | Chemwill Asia Co.,Ltd. | ||
 |
2020-01-13 | 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
20870-77-3
|
$5.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 4-Chloro-2-oxindole 4-Chloro-1,3-dihydro-indol-2-one in stock Factory
20870-77-3
- $1.00
- High quality purified Factory in China
- Chemwill Asia Co.,Ltd.
-
- 4-CHLORO-1,3-DIHYDRO-INDOL-2-ONE
20870-77-3
- $5.00
- 98%
- Career Henan Chemical Co
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