D-MANNOHEPTULOSE
- CAS No.
- 3615-44-9
- Chemical Name:
- D-MANNOHEPTULOSE
- Synonyms
- Ai3-61577;Nsc 226836;MANNOHEPTULOSE;D-MANNOHEPTULOSE;Einecs 222-795-5;Mannoheptulose,D-;D-Mannoketoheptose;D-manno-2-heptulose;ALPHA-D-MANNOHEPTULOSE;D-Manno-heptulose (8ci)
- CBNumber:
- CB4744708
- Molecular Formula:
- C7H14O7
- Molecular Weight:
- 210.18
- MDL Number:
- MFCD00037814
- MOL File:
- 3615-44-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| D-Mannoheptulose ≥99.0% (HPLC) | 97318 | 25mg | $695 |
| D-Mannoheptulose ≥98% | 16548 | 5mg | $49 |
| D-Mannoheptulose ≥98% | 16548 | 10mg | $92 |
| D-Mannoheptulose ≥98% | 16548 | 25mg | $216 |
| D-Mannoheptulose ≥98% | 16548 | 50mg | $380 |
| Melting point | 148-150°C |
|---|---|
| alpha | D20 +29° (c = 2 in H2O) |
| Boiling point | 628.0±55.0 °C(Predicted) |
| Density | 1.645±0.06 g/cm3(Predicted) |
| storage temp. | Refrigerator |
| solubility | Methanol (Slightly), Water (Slightly) |
| pka | 11.86±0.20(Predicted) |
| form | Solid |
| color | White to Off-White |
| optical activity | +29 |
| Merck | 13,4686 |
| BRN | 1726433 |
| InChI | 1S/C7H14O7/c8-1-3-4(10)5(11)6(12)7(13,2-9)14-3/h3-6,8-13H,1-2H2/t3-,4-,5+,6+,7/m1/s1 |
| InChIKey | HAIWUXASLYEWLM-BWSJPXOBSA-N |
| SMILES | OC[C@H]1OC(O)(CO)[C@@H](O)[C@@H](O)[C@@H]1O |
| FDA UNII | W19YH62373 |
| EPA Substance Registry System | D-manno-2-Heptulose (3615-44-9) |
| UNSPSC Code | 12352201 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Safety Statements | 24/25 |
| WGK Germany | 2 |
| TSCA | TSCA listed |
| HS Code | 29400090 |
| Storage Class | 11 - Combustible Solids |
D-MANNOHEPTULOSE price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 97318 | D-Mannoheptulose ≥99.0% (HPLC) | 3615-44-9 | 25mg | $695 | 2026-03-19 | Buy |
| Cayman Chemical | 16548 | D-Mannoheptulose ≥98% | 3615-44-9 | 5mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 16548 | D-Mannoheptulose ≥98% | 3615-44-9 | 10mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 16548 | D-Mannoheptulose ≥98% | 3615-44-9 | 25mg | $216 | 2024-03-01 | Buy |
| Cayman Chemical | 16548 | D-Mannoheptulose ≥98% | 3615-44-9 | 50mg | $380 | 2024-03-01 | Buy |
D-MANNOHEPTULOSE Chemical Properties,Uses,Production
Description
D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM). It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein. By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose.
Chemical Properties
White Solid
Uses
Mannoheptulose occurs naturally in avocado fruit. It is used for normalizing insulin levels and reducing weight.
Definition
ChEBI: D-keto-manno-heptulose is the open chain form of D-manno-heptulose.
References
[1] H G COORE P J R. Inhibition of glucose phosphorylation by mannoheptulose.[J]. Biochemical Journal, 1964, 91 1: 56-59. DOI: 10.1042/bj0910056
[2] S J ASHCROFT P J R. Enzymes of glucose metabolism in normal mouse pancreatic islets.[J]. Biochemical Journal, 1970, 119 1: 5-15. DOI: 10.1042/bj1190005
[3] N DAI. Overexpression of Arabidopsis hexokinase in tomato plants inhibits growth, reduces photosynthesis, and induces rapid senescence.[J]. Plant Cell, 1999, 11 7: 1253-1266. DOI: 10.1105/tpc.11.7.1253
[4] S J ASHCROFT P J R L C Weerasinghe. Interrelationship of islet metabolism, adenosine triphosphate content and insulin release.[J]. Biochemical Journal, 1973, 132 2: 223-231. DOI: 10.1042/bj1320223
[5] DANIEL JOHNSON. Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50, a glucokinase activator.[J]. Diabetes, 2007, 56 6: 1694-1702. DOI: 10.2337/db07-0026
[6] MING V. LI . Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP)[J]. Biochemical and biophysical research communications, 2010, 395 3: Pages 395-400. DOI: 10.1016/j.bbrc.2010.04.028
[7] LESLIE L MCKNIGHT. Mannoheptulose has differential effects on fasting and postprandial energy expenditure and respiratory quotient in adult Beagle dogs fed diets of different macronutrient contents.[J]. Journal of Nutritional Science, 2014, 3: e17. DOI: 10.1017/jns.2014.17
D-MANNOHEPTULOSE Preparation Products And Raw materials
Raw materials
Preparation Products
D-MANNOHEPTULOSE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30228 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 18895 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-27-59207850 | info@fortunachem.com | China | 5972 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046; | sales01@watsonbiotech.cn | China | 5738 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53802 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32321 | 50 |
View Lastest Price from D-MANNOHEPTULOSE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-10 | D-Mannoheptulose
3615-44-9
|
US $0.00 / G | 10G | 98%min | 30kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
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- D-Mannoheptulose
3615-44-9
- US $0.00 / G
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
