Silver sulfadiazine
- CAS No.
- 22199-08-2
- Chemical Name:
- Silver sulfadiazine
- Synonyms
- SILVER SULPHADIAZINE;silvadene;flamazine;SULFADIAZINE SILVER;SILVER(I) SULFADIAZINE;SD-Ag;geben;Dermazin;Nsc625324;dermazine
- CBNumber:
- CB4744940
- Molecular Formula:
- C10H9AgN4O2S
- Molecular Weight:
- 357.14
- MDL Number:
- MFCD00072101
- MOL File:
- 22199-08-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 285 °C (dec.)(lit.) |
|---|---|
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| form | powder |
| color | White to Off-White |
| Merck | 14,8903 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Major Application |
PEM fuel cells material synthesis precursor |
| InChI | 1S/C10H9N4O2S.Ag/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10;/h1-7H,11H2;/q-1;+1 |
| InChIKey | UEJSSZHHYBHCEL-UHFFFAOYSA-N |
| SMILES | Nc1ccc(cc1)S(=O)(=O)N([Ag])c2ncccn2 |
| CAS DataBase Reference | 22199-08-2(CAS DataBase Reference) |
| FDA UNII | W46JY43EJR |
| NCI Drug Dictionary | Silvadene |
| ATC code | D06BA01,D06BA51 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | WP1950000 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2935904000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Silver sulfadiazine price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 481181 | Silver(I) sulfadiazine 98% | 22199-08-2 | 5g | $71.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR2654 | Silver Sulfadiazine Pharmaceutical Secondary Standard; Certified Reference Material | 22199-08-2 | 500MG | $280 | 2026-04-30 | Buy |
| Sigma-Aldrich | 1612608 | Silver sulfadiazine United States Pharmacopeia (USP) Reference Standard | 22199-08-2 | 200mg | $554 | 2026-04-30 | Buy |
| TCI Chemical | S0595 | Silver Sulfadiazine >98.0%(HPLC)(T) | 22199-08-2 | 5g | $58 | 2026-04-30 | Buy |
| TCI Chemical | S0595 | Silver Sulfadiazine >98.0%(HPLC)(T) | 22199-08-2 | 25g | $187 | 2026-04-30 | Buy |
Silver sulfadiazine Chemical Properties, Uses, Production
Chemical Properties
solid
Uses
Indicated as an adjunct for the prevention and treatment of wound sepsis in patients with second- and third-degree burns.
Uses
Coordination compound. Antibacterial
Uses
Silver(I) sulfadiazine (AgSD) is popularly used for treating second-degree burn wounds as it acts as an antimicrobial agent and prevents infections. Silver sulfadiazine-impregnated polyurethane (PU) foam, chitosan/chondroitin sulfate films may be used for wound dressing.
Definition
ChEBI: Silver(1+) sulfadiazinate is a silver salt, a sulfonamidate and a member of pyrimidines. It has a role as an antimicrobial agent and an antibacterial drug. It contains a sulfadiazinate.
Indications
Silver sulfadiazine (Silvadene, SSD) is a synthetic agent that combines the beneficial
properties of silver nitrate and sulfonamides. It acts upon the cell membrane and cell
wall. It is used primarily as an adjunct in the prevention and treatment of wound
sepsis in patients with second- and third-degree burns and for wound care of chronic
ulcers. It is bactericidal against many gram-positive and gram-negative bacteria as
well as C. albicans and is reasonably effective against P. aeruginosa and S. aureus.
Bacteria susceptible to sulfadiazine but resistant to silver nitrate, as well as those
sensitive to silver nitrate but resistant to sulfadiazine, have shown good response
to silver sulfadiazine. It does not stain, is unlikely to produce electrolyte imbalance,
and does not cause systemic acidosis. Some patients note a stinging sensation on
application, and because this compound can be absorbed, systemic sulfonamide
reactions similar to those caused by sulfonamides may occur.
Pharmaceutical Applications
Silver sulfadiazine is indicated for the prophylaxis and treatment of infections in burn wounds. Silver sulfadiazine
is highly insoluble in water, and as a result, it does not cause hypochloraemia in burns in contrast to
silver nitrate.
The active ingredient silver sulfadiazine is a sulfur-derived topical antibacterial used primarily on secondand
third-degree burns. It is known to be active against many Gram-negative and Gram-positive bacteria as
well as against yeast. The cream is kept applied to the burned skin at all times for the duration of the healing
period or until a graft is applied. It prevents the growth of a wide array of bacteria, as well as yeast, on the
damaged skin. Caution has to be given to large-area application as sulfadiazine levels in the plasma may well
reach therapeutic levels that can cause side effects.
Pharmaceutical Applications
Silver sulfadiazine is extremely insoluble. In addition to the
usual activity of sulfonamides it exhibits activity – almost certainly
attributable to the silver component – against Ps. aeruginosa
and some fungi.
It is variably absorbed after topical application depending
on the integrity of the skin. Toxic concentrations may
be achieved in patients with extensive burns. It is used topically,
mainly for burns, pressure sores and leg ulcers. Central
venous catheters impregnated with chlorhexidine and silver
sulfadiazine have been developed to reduce bacterial colonization.
Other suggested uses include the prevention of
infection in skin graft donor sites and cord care in newborn
infants.
Clinical Use
The silver salt of sulfadiazine applied in a water-misciblecream base has proved to be an effective topical antimicrobialagent, especially against Pseudomonas spp. This is particularlysignificant in burn therapy because pseudomonadsare often responsible for failures in therapy. The salt is onlyslightly soluble and does not penetrate the cell wall butacts on the external cell structure. Studies using radioactivesilver have shown essentially no absorption into body fluids.Sulfadiazine levels in the serum were about 0.5 to2 mg/100 mL.
This preparation is reported to be easier to use thanother standard burn treatments, such as application offreshly prepared dilute silver nitrate solutions or mafenideointment.
Synthesis
The current method of producing silver sulfadiazine salt is to react sulfadiazine powder with silver nitrate to produce silver sulfadiazine salt. In production, the amount of sulfadiazine is usually increased by about 10% in order to increase the utilization of the more expensive silver nitrate.
Veterinary Drugs and Treatments
Silver sulfadiazine cream is a broad spectrum agent which covers bacteria (gram positive and negative) and fungal agents. It has been used extensively in people suffering from skin burns. It is nontoxic to the skin, conjunctiva and cornea and has been used in the last several years for cases of fungal keratitis. Particularly good results have been noted in cases of superficial keratitis prior to development of advanced disease. Clinical response is better when used early in the course of the disease. Treatment with silver sulfadiazine is considered non-conventional in people. It is gaining in popularity in the treatment of equine fungal keratitis by veterinary ophthalmologists. For medico-legal reasons, in very expensive horses in which litigation may be an issue, treatment with more conventional therapy (natamycin) may be indicated first, or consideration can be given to signed consent regarding treatment with silver sulfadiazine. The initial response to this drug has been promising, however.
Veterinary Drugs and Treatments
Topical silver sulfadiazine (SSD) is used topically for prophylaxis and treatment of 2nd and 3rd degree burns. It is also useful in treating localized
pyodermas caused by Pseudomonas spp.
SSD has extensive antimicrobial activity and is bactericidal for yeasts and many gram-negative and gram-positive bacteria. SSD acts via
disrupting microbial cell membranes and cell walls; this differs from the antibacterial actions of silver nitrate or sodium sulfadiazine.
Silver sulfadiazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6744 | 52 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Latest Price from Silver sulfadiazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Silver sulfadiazine
22199-08-2
|
1KG | 98%-102% | 1000KGS | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Silver sulfadiazine
22199-08-2
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-09-01 | Silver Sulphadiazine
22199-08-2
|
1kg | 99% | 1000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd |
-
- Silver sulfadiazine
22199-08-2
- $0.00
- 98%-102%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Silver sulfadiazine
22199-08-2
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- Silver Sulphadiazine
22199-08-2
- $0.00
- 99%
- Shaanxi TNJONE Pharmaceutical Co., Ltd
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