2,6-Dihydroxybenzaldehyde
- CAS No.
- 387-46-2
- Chemical Name:
- 2,6-Dihydroxybenzaldehyde
- Synonyms
- 2,6-DIHYDROXYBENZALDEHYDE;2,6-Dihydroxy Benzoldehyde;Benzaldehyde, 2,6-dihydroxy-;2,6-dihydroxybenzaldehyde(387-46-2)
- CBNumber:
- CB4747901
- Molecular Formula:
- C7H6O3
- Molecular Weight:
- 138.12
- MDL Number:
- MFCD08061915
- MOL File:
- 387-46-2.mol
| Melting point | 154-155°C |
|---|---|
| Boiling point | 223°C |
| Density | 1.409 |
| Flash point | 103°C |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.66±0.10(Predicted) |
| color | Pale Yellow to Light Yellow |
| Stability | Hygroscopic |
| InChI | InChI=1S/C7H6O3/c8-4-5-6(9)2-1-3-7(5)10/h1-4,9-10H |
| InChIKey | DGXAGETVRDOQFP-UHFFFAOYSA-N |
| SMILES | C(=O)C1=C(O)C=CC=C1O |
| FDA UNII | K89FJ2AWV2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H335-H315-H318 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310 |
| REACH Registrations | Active |
2,6-Dihydroxybenzaldehyde price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-D451015-5G | 2,6-Dihydroxybenzaldehyde | 387-46-2 | 5g | $498 | 2026-06-03 | Buy |
| TRC | TRC-D451015-2.5G | 2,6-Dihydroxybenzaldehyde | 387-46-2 | 2.5g | $256 | 2026-06-03 | Buy |
| TRC | TRC-D451015-10G | 2,6-Dihydroxybenzaldehyde | 387-46-2 | 10g | $708 | 2026-06-03 | Buy |
| Biosynth | FD63326 | 2,6-Dihydroxybenzaldehyde | 387-46-2 | 10g | $150 | 2026-06-04 | Buy |
| Biosynth | FD63326 | 2,6-Dihydroxybenzaldehyde | 387-46-2 | 25g | $150 | 2026-06-04 | Buy |
2,6-Dihydroxybenzaldehyde Chemical Properties, Uses, Production
Uses
2,6-Dihydroxybenzaldehyde is a reactant used in the synthesis of cinnamides as potent cholinesterase inhibitors.
Definition
ChEBI: 2,6-dihydroxybenzaldehyde is a dihydroxybenzaldehyde.
Synthesis
3392-97-0
387-46-2
The general procedure for the synthesis of 2,6-dihydroxybenzaldehyde from 2,6-dimethoxybenzaldehyde was as follows: a dichloromethane (1200 mL) solution of AlCl3 (240 g, 1.80 mol, 3.00 eq.) was added to a 3000 mL three-necked round bottom flask. The reaction mixture was cooled to 0 °C, followed by the slow dropwise addition of a dichloromethane (800 mL) solution of 2,6-dimethoxybenzaldehyde (100 g, 601.78 mmol, 1.00 equiv). After the dropwise addition was completed, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction was quenched with 200 mL of dilute hydrochloric acid (2 M). The reaction mixture was extracted with dichloromethane (2 x 200 mL). The organic layers were combined and concentrated under vacuum. The concentrated residue was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:200 to 1:50) as eluent to give 40 g (48% yield) of 2,6-dihydroxybenzaldehyde as a yellow solid. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 11.25 (s, 2H), 10.25 (s, 1H), 7.36 (m, 1H), 6.36 (d, J = 8.4 Hz, 2H); mass spectrum (ESI) m/z 139 [M + H]+.
References
[1] Green Chemistry, 2018, vol. 20, # 4, p. 804 - 808
[2] Chemistry - A European Journal, 2009, vol. 15, # 1, p. 125 - 135
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 14, p. 6772 - 6790
[4] Patent: CN105566276, 2016, A. Location in patent: Paragraph 0130; 0134; 0135; 0136
[5] Helvetica Chimica Acta, 2005, vol. 88, # 1, p. 120 - 153
2,6-Dihydroxybenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou AnMusi Chemical Products Co., Ltd. | 15981811963 18737195735 | 2370407954@qq.com | China | 1979 | 55 |
| Bengbu Nako Chemical Co., Ltd. | 0552-3068102 13966060073 | sales@nakochem.com | China | 26 | 58 |
| Hangzhou Milon Pharmatech Co.,Ltd. | 18083715844 | sales@milonpharm.com | China | 346 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. | 21-54820552 17702105771 | 188738128@qq.com | China | 300 | 66 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 2,6-Dihydroxybenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 2,6-Dihydroxybenzaldehyde
387-46-2
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-01-13 | 2,6-Dihydroxybenzaldehyde
387-46-2
|
1kg | 97.0%min；99.0%min | 60KG/Batch | Hangzhou Milon Pharmatech Co.,Ltd. | ||
 |
2025-06-27 | 2,6-Dihydroxybenzaldehyde
387-46-2
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 2,6-Dihydroxybenzaldehyde
387-46-2
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2,6-Dihydroxybenzaldehyde
387-46-2
- 97.0%min；99.0%min
- Hangzhou Milon Pharmatech Co.,Ltd.
-
- 2,6-Dihydroxybenzaldehyde
387-46-2
- $0.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
