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2-Chloropyridine-N-oxide

2-Chloropyridine-N-oxide Structure
2-Chloropyridine-N-oxide structure
CAS No.
2402-95-1
Chemical Name:
2-Chloropyridine-N-oxide
Synonyms
N-oxy-2-cloropyridine;N-OXY-2-CHLORPYRIDINE;2-CHLOROPYRIDINE N-OXID;2-CHLOROPYRIDINE N-OXIDE;2-chloropyridine 1-oxide;Pyridine,2-chloro-,1-oxide;2-chloro-1-oxidopyridin-1-ium;2-Chloropyridine n-oxide ,97%;2-chloropyridin-1-ium-1-olate;2-chloro-1$l^{5}-pyridin-1-one
CBNumber:
CB0403087
Molecular Formula:
C5H4ClNO
Molecular Weight:
129.54
MDL Number:
MFCD00129036
MOL File:
2402-95-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-27 22:38:53
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2-Chloropyridine-N-oxide Properties

Melting point 67-70°C
Boiling point 168-170C
Density 1,209g/cm
refractive index 1,531-1,533
pka -0.76±0.10(Predicted)
Water Solubility Insoluble in water.
Sensitive Moisture Sensitive
BRN 108585
InChI InChI=1S/C5H4ClNO/c6-5-3-1-2-4-7(5)8/h1-4H
InChIKey WYSRTEVFLQJJDN-UHFFFAOYSA-N
SMILES C1(Cl)[N+]([O-])=CC=CC=1
CAS DataBase Reference 2402-95-1(CAS DataBase Reference)
FDA UNII 1B7DYF9G1Z

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Warning
Hazard statements  H302-H312-H315-H319-H331-H335
Precautionary statements  P261-P280-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  23/24/25-36/37/38-20/21/22
Safety Statements  26-36/37/39-45-36-36/37
RIDADR  2811
HazardClass  6.1
PackingGroup  II
HS Code  29333990
NFPA 704
1
2 0

2-Chloropyridine-N-oxide price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 270273 2-Chloropyridine N-oxide Asreported 2402-95-1 2g $333 2026-06-03 Buy
Usbiological 270273 2-Chloropyridine N-oxide Asreported 2402-95-1 5g $470 2026-06-03 Buy
Usbiological 270273 2-Chloropyridine N-oxide Asreported 2402-95-1 10g $632 2026-06-03 Buy
Usbiological 270273 2-Chloropyridine N-oxide Asreported 2402-95-1 25g $848 2026-06-03 Buy
Activate Scientific AS131746 2-Chloropyridine 1-Oxide 95% 2402-95-1 5g $37 2026-06-04 Buy
Product number Packaging Price Buy
270273 2g $333 Buy
270273 5g $470 Buy
270273 10g $632 Buy
270273 25g $848 Buy
AS131746 5g $37 Buy

2-Chloropyridine-N-oxide Chemical Properties, Uses, Production

Synthesis

There are many methods for synthesizing 2-chloropyridine-N-oxides, such as the hydrogen peroxide oxidation method, the peroxyacetic acid oxidation method, and the sodium perborate oxidation method. This experiment used tungstic acid and sulfuric acid as catalysts and hydrogen peroxide as an oxidant. Comparative experiments were conducted on the amounts of catalyst and oxidant, reaction temperature, and reaction time to explore the optimal reaction conditions and provide basic data for the synthesis of 2-chloropyridine N-oxides.

Synthesis of 2402-95-1

In a 250mL four-necked flask equipped with an electric stirrer, thermometer, spherical condenser, and constant-pressure dropping funnel, add 25mL of 2-chloropyridine, 28mL of distilled water, 1.1mL of 98% concentrated sulfuric acid, and 2.2g of tungstic acid. Start the stirrer, and then measure 30mL of hydrogen peroxide into the constant-pressure dropping funnel. Adjust the water bath temperature. When the reaction solution temperature reaches 70℃, start adding hydrogen peroxide dropwise, controlling the temperature at 70-80℃. The addition is completed in about 12 hours. Then, continue stirring at 75-80℃ and keep warm for 24 hours. Take samples every 3 hours, for a total of 8 samples.

After the reaction, the solution turned into a pale yellow transparent solution. After cooling to room temperature, the sample was analyzed by gas chromatography, and the conversion rate was calculated. 2.5 g of CaO was added to a small beaker, followed by distilled water to prepare a Ca(OH)₂ emulsion. The pH of the reaction solution was adjusted to 6–7 using this emulsion. The mixture was stirred at room temperature for 1 hour, resulting in the formation of a precipitate, CaWO₄. The precipitate was filtered, washed, and dried. An equimolar amount of dilute hydrochloric acid was added to the filtrate to form a salt. The water was evaporated to dryness using a water pump under reduced pressure to obtain the hydrochloride of nitrogen-oxidized 2-chloropyridine, a pale yellow solid with a melting point of 141–143 °C, consistent with the theoretical value. The yield was calculated based on this.

Chemical Properties

White solid

Uses

2-Chloropyridine oxide is a cytotoxic and clastogenic compound.

2-Chloropyridine-N-oxide synthesis

109-09-1
2402-95-1
Synthesis of 2-Chloropyridine-N-oxide from 2-Chloropyridine

2-Chloropyridine-N-oxide Preparation Products And Raw materials

Raw materials

Peroxyacetic acid Acetic acid 2-Chloropyridine 2-nitro-1-oxidopyridin-1-ium 2-Aminopyridine N-oxide
Acetyl chloride

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Preparation Products

4-Amino-2-chloropyridine Ethyl 3-pyridylacetate HEPTANOIC ANHYDRIDE Forchlorfenuron TOSUFLOXACIN TOSILATE
2-chloro-5-ethylaminomethylpyridine 2-Chloro-4-bromopyridine 2-Amino-6-chloropyridine 4-Chloro-1-H-imidazo[4,5-c]pyridine 2-Chloro-4-nitropyridine
Sodium Pyrithione 2-Pyridinethiol 1-oxide

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2-Chloropyridine-N-oxide Suppliers

Global Suppliers ( 204)
Supplier Tel Email Country ProdList Advantage
Chongqing Botao Biotechnology Co., LTD 15223382610 danny@chemdad.com China 2030 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
SpringPharma Tech Co.,Ltd +86-25-68710855, +86-25-68710897 sales@springpharma.net China 1260 62
Supplier Advantage
Chongqing Botao Biotechnology Co., LTD 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
SpringPharma Tech Co.,Ltd 62

View Latest Price from 2-Chloropyridine-N-oxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloropyridine-N-oxide pictures 2026-08-20 2-Chloropyridine-N-oxide
2402-95-1
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Chloropyridine-N-oxide pictures 2026-06-30 2-Chloropyridine-N-oxide
2402-95-1
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Chloropyridine-N-oxide pictures 2026-06-30 2-Chloropyridine-N-oxide
2402-95-1
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

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2-CHLOROPYRIDINE N-OXIDE N-OXY-2-CHLORPYRIDINE Pyridine,2-chloro-,1-oxide 2-chloropyridine 1-oxide Pyridine, 2-chloro-, 1-oxide (7CI,8CI,9CI) 2-chloro-1-oxidanidyl-pyridin-1-ium 2-chloro-1-oxido-pyridin-1-ium 2-chloro-1-oxidopyridin-1-ium N-oxy-2-cloropyridine 2-Chloropyridine n-oxide ,97% 2-chloro-1$l^{5}-pyridin-1-one 2-CHLOROPYRIDINE N-OXID 2-chloropyridin-1-ium-1-olate 2-Chloropyridine-N-oxide ISO 9001：2015 REACH Trans-4-methylcyclohexylamine.methanesulfonate 2402-95-1 C5H4ClNO PYRIDINE Pyridines