METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
- CAS No.
- 39977-44-1
- Chemical Name:
- METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
- Synonyms
- Methyl 6-(hydroxymethyl);Methyl 6-(hydroxymethyl)picolinate;Methyl-6-hydroxymethyl-2-carboxylate;6-(hydroxymethyl)-2-pyridinecarboxylate;METHYL-6-HYDROXYMETHYL-2-PYRIDINE-CARBOXYLATE;METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE;methyl 6-(hydroxymethyl)pyridine-2-carboxylate;Methyl 6-hydroxyMethyl-2-pyridine carboxylic acid;2-hydroxymethylpyridine-6-carboxylic acid methyl ester;6-Hydroxymethyl-pyridine-2-carboxylic acid methyl ester
- CBNumber:
- CB4775911
- Molecular Formula:
- C8H9NO3
- Molecular Weight:
- 167.16
- MDL Number:
- MFCD03840850
- MOL File:
- 39977-44-1.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Methyl6-(Hydroxymethyl)-2-pyridinecarboxylate | M312835 | 1g | $165 |
| Methyl6-(hydroxymethyl)picolinate 98% | 214916 | 100g | $540 |
| Methyl 6-(hydroxymethyl)picolinate 97% | 070838 | 5g | $699 |
| METHYL-6-HYDROXYMETHYL-2-PYRIDINE CARBOXYLATE 95.00% | CHM0034773 | 5G | $1518.83 |
| Methyl6-(hydroxymethyl)picolinate 98% | 214916 | 500g | $1620 |
| More product size | |||
| Melting point | 178 °C |
|---|---|
| Boiling point | 327.3±32.0 °C(Predicted) |
| Density | 1.244 |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Solid |
| pka | 13.03±0.10(Predicted) |
| color | White |
| InChI | InChI=1S/C8H9NO3/c1-12-8(11)7-4-2-3-6(5-10)9-7/h2-4,10H,5H2,1H3 |
| InChIKey | DVIUNMLAPDJWHL-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC(CO)=CC=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | M312835 | Methyl6-(Hydroxymethyl)-2-pyridinecarboxylate | 39977-44-1 | 1g | $165 | 2021-12-16 | Buy |
| Oakwood | 214916 | Methyl6-(hydroxymethyl)picolinate 98% | 39977-44-1 | 100g | $540 | 2021-12-16 | Buy |
| Matrix Scientific | 070838 | Methyl 6-(hydroxymethyl)picolinate 97% | 39977-44-1 | 5g | $699 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CHM0034773 | METHYL-6-HYDROXYMETHYL-2-PYRIDINE CARBOXYLATE 95.00% | 39977-44-1 | 5G | $1518.83 | 2021-12-16 | Buy |
| Oakwood | 214916 | Methyl6-(hydroxymethyl)picolinate 98% | 39977-44-1 | 500g | $1620 | 2021-12-16 | Buy |
METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Chemical Properties,Uses,Production
Chemical Properties
White or off-white solid
Uses
Methyl 6-(Hydroxymethyl)-2-pyridinecarboxylate is a chemical compound used in the synthesis of Losartan (L470500) derivatives as AT1 antagonists in the preparation of antihypertensive agents. Also used to prepare telomerase inhibitors for in vivo inhibitory activity.
Synthesis
Into a 100-mL round-bottom flask, was placed a solution of 2,6-dimethyl pyridine-2,6- dicarboxylate (950 mg, 4.87 mmol, 1.00 equiv) in a solvent mixture of methanol (33.2 mL) and dichloromethane (14.2 mL). NaB (185 mg, 5.02 mmol, 1.00 equiv) was added to the reaction mixture in several batches at 0°C. The resulting solution was stirred overnight at room temperature, and then it was quenched by the addition of 50 mL of NC1 (aq.). The resulting solution was extracted with 2x50 mL of dichloromethane and the combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (1 : 1-2: 1) as eluent to yield 750 mg (92%) of methyl 6-(hydroxymethyl)pyridine-2-carboxylate as a white solid.
References
[1] Patent: WO2013/102145, 2013, A1. Location in patent: Paragraph 0333
[2] Patent: US2015/344483, 2015, A1. Location in patent: Paragraph 0616; 0617
[3] Chemistry - A European Journal, 2017, vol. 23, # 21, p. 5154 - 5170
[4] Chemistry - A European Journal, 2006, vol. 12, # 24, p. 6393 - 6402
[5] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 4, p. 609 - 612
METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1299 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Win-Win Chemical CO., Limited | 0086-577-64498589 | sales@win-winchemical.com | CHINA | 998 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
View Lastest Price from METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
39977-44-1
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-10-13 | Methyl 6-(hydroxymethyl)picolinate
39977-44-1
|
US $1.10-9.90 / kg | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2019-07-12 | METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
39977-44-1
|
US $1.00 / KG | 1KG | 99% | 100kg | Career Henan Chemical Co |
-
- METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
39977-44-1
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 6-(hydroxymethyl)picolinate
39977-44-1
- US $1.10-9.90 / kg
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- METHYL-6-HYDROXYMETHYL-2-CARBOXYLATE PYRIDINE
39977-44-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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