ChemicalBook >> CAS DataBase List >>tert-Butyl 4-cyanobenzylcarbamate

tert-Butyl 4-cyanobenzylcarbamate

tert-Butyl 4-cyanobenzylcarbamate structure

CAS No.: 66389-80-8

Chemical Name:: tert-Butyl 4-cyanobenzylcarbamate

Synonyms: N-Boc-4-cyanobenzylamine;4-BOC-AMINOMETHYL-BENZONITRILE;tert-Butyl 4-cyanobenzylcarbamate;tert-butyl N-[(4-cyanophenyl)methyl]carbamate;1,1-Dimethylethyl N-[(4-cyanophenyl)methyl]carbamate;Carbamic acid, N-[(4-cyanophenyl)methyl]-, 1,1-dimethylethyl ester

CBNumber:: CB4841968

Molecular Formula:: C13H16N2O2

Molecular Weight:: 232.28

MDL Number:: MFCD08436197

MOL File:: 66389-80-8.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:01

Request For Quotation

tert-Butyl 4-cyanobenzylcarbamate Properties

Melting point	90-92 °C
Boiling point	392.9±35.0 °C(Predicted)
Density	1.10±0.1 g/cm3(Predicted)
storage temp.	2-8°C
pka	11.91±0.46(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338

tert-Butyl 4-cyanobenzylcarbamate price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Biosynth	FB140510	tert-Butyl 4-cyanobenzylcarbamate	66389-80-8	1g	$230.6	2026-06-04	Buy
Biosynth	FB140510	tert-Butyl 4-cyanobenzylcarbamate	66389-80-8	2g	$345.92	2026-06-04	Buy
Biosynth	FB140510	tert-Butyl 4-cyanobenzylcarbamate	66389-80-8	5g	$768.65	2026-06-04	Buy
Biosynth	FB140510	tert-Butyl 4-cyanobenzylcarbamate	66389-80-8	10g	$1441.3	2026-06-04	Buy
Activate Scientific	AS29620	4-(Boc-aminomethyl)benzonitrile 97%	66389-80-8	1g	$29	2026-06-04	Buy

Product number	Packaging	Price	Buy
FB140510	1g	$230.6	Buy
FB140510	2g	$345.92	Buy
FB140510	5g	$768.65	Buy
FB140510	10g	$1441.3	Buy
AS29620	1g	$29	Buy

tert-Butyl 4-cyanobenzylcarbamate Chemical Properties, Uses, Production

Synthesis

24424-99-5

4-(Aminomethyl)benzonitrile hydrochloride

15996-76-6

66389-80-8

(1) To a solution of 4-(aminomethyl)benzonitrile hydrochloride (5.00 g, 29.7 mmol) in dichloromethane (167 mL) at 0 °C was added sodium carbonate (7.54 g, 71.2 mmol). Subsequently, di-tert-butyl dicarbonate (7.57 mL, 32.6 mmol) was slowly added. The reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, water was added to terminate the reaction and the product was extracted with ethyl acetate. The organic layer was washed sequentially with water and saturated sodium chloride solution and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure, and the resulting crude product was purified by silica gel (NH) column chromatography (eluent: n-hexane/ethyl acetate=1:1) to give tert-butyl 4-cyanobenzylcarbamate (6.48 g, 94% yield).

References

[1] Angewandte Chemie - International Edition, 2012, vol. 51, # 18, p. 4431 - 4434
[2] Chemistry - A European Journal, 2018, vol. 24, # 68, p. 18075 - 18081
[3] Patent: WO2017/18803, 2017, A1. Location in patent: Paragraph 1552; 1553; 1554
[4] Journal of the American Chemical Society, 2012, vol. 134, # 25, p. 10317 - 10320
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 2, p. 528 - 533

tert-Butyl 4-cyanobenzylcarbamate Preparation Products And Raw materials

Raw materials

Di-tert-butyl iminodicarboxylate Di-tert-butyl dicarbonate 4-(Aminomethyl)benzonitrile hydrochloride 4-Cyanobenzyl bromide 4-Cyanobenzylamine

Dichloromethane Sodium carbonate

1of2

Preparation Products

Methyltetrazine-amine hydrochloride Tetrazine amine HCl Salt tert-Butyl 4-(N-hydroxycarbamimidoyl)-benzylcarbamate

tert-Butyl 4-cyanobenzylcarbamate Suppliers

Global Suppliers ( 77)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	15721252604 17321035817	sales@harvest-chem.com	China	2829	64
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Beijing FYF Chemicals Co., Ltd	010-57903446 15869909019	168931144@qq.com	China	2876	58
Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd	18210788515; 18210788515	zhuzixin999@163.c0m	China	4999	55
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
BePharm Ltd	400-685-9117	market@bepharm.com	China	15081	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Yantai ShengKailun Chemical Technology Co., Ltd.	13356901049	3119594100@qq.com	China	7964	55
MQ (shanghai) Pharmaceuticals Co., Ltd.	13761635123	sales@linyuepharm.com	China	5731	55
Amatek Scientific Co. Ltd.	0512-56316828 400-867-5858;400-867-5858	info@amateksci.com	China	28760	58

Supplier	Advantage
Shanghai Harvest Chemical Industrial Co., Ltd.	64
Bide Pharmatech Ltd.	60
Beijing FYF Chemicals Co., Ltd	58
Zhengzhou kangnuochenrui Chemical Technology Co.,Ltd	55
Shanghai YuanYe Biotechnology Co., Ltd.	60
BePharm Ltd	60
Amadis Chemical Company Limited	58
Yantai ShengKailun Chemical Technology Co., Ltd.	55
MQ (shanghai) Pharmaceuticals Co., Ltd.	55
Amatek Scientific Co. Ltd.	58

View Latest Price from tert-Butyl 4-cyanobenzylcarbamate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	TERT-BUTYL 4-CYANOBENZYLCARBAMATE 66389-80-8	$60.00-360.00	5g	99%	50	Zibo Hangyu Biotechnology Development Co., Ltd
2026-08-25	TERT-BUTYL 4-CYANOBENZYLCARBAMATE 66389-80-8	$55.00-700.00	5g	99%	50	Zibo Hangyu Biotechnology Development Co., Ltd
2019-07-06	TERT-BUTYL 4-CYANOBENZYLCARBAMATE 66389-80-8	$1.00	1KG	99%	1ton	Career Henan Chemical Co

TERT-BUTYL 4-CYANOBENZYLCARBAMATE
66389-80-8
$60.00-360.00
99%
Zibo Hangyu Biotechnology Development Co., Ltd

TERT-BUTYL 4-CYANOBENZYLCARBAMATE
66389-80-8
$55.00-700.00
99%
Zibo Hangyu Biotechnology Development Co., Ltd

TERT-BUTYL 4-CYANOBENZYLCARBAMATE
66389-80-8
$1.00
99%
Career Henan Chemical Co

66389-80-8 (tert-Butyl 4-cyanobenzylcarbamate) Related Search:

tert-Butyl 5-cyanoisoindoline-2-carboxylate tert-Butyl 4-cyano-3-fluorobenzylcarbamate N-Boc-3-(4-cyanophenyl)oxaziridine (R)-Boc-4-cyano-beta-Phe-OH (S)-Boc-4-cyano-beta-Phe-OH

N,N-Di-Boc-4-aminomethyl benzonitrile 4-(Di-t-Boc-aminomethyl)-3-chlorobenzonitrile tert-Butyl 4-cyanobenzylcarbamate 3-N-Boc-3-(4-cyanophenyl)propionic acid tert-butyl 6-cyano-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-Butyl 2-chloro-4-cyanobenzylcarbamate tert-Butoxycarbonylamino-(4-cyano-phenyl)-acetic acid Benzeneacetic acid,4-nitro-, 1,1-dimethylethyl ester Carbamic acid, (3-bromo-2-pyridinyl)-, 1,1-dimethylethyl ester tert-butyl 6-broMonaphthalen-2-ylcarbaMate

tert-Butyl 7-amino-1H-indole-1-carboxylate tert-Butyl 2-cyclohexylhydrazinecarboxylate [1-(4-Bromo-phenyl)-ethyl]-carbamic acid tert-butyl ester

1of4

4-BOC-AMINOMETHYL-BENZONITRILE N-Boc-4-cyanobenzylamine tert-butyl N-[(4-cyanophenyl)methyl]carbamate Carbamic acid, N-[(4-cyanophenyl)methyl]-, 1,1-dimethylethyl ester 1,1-Dimethylethyl N-[(4-cyanophenyl)methyl]carbamate tert-Butyl 4-cyanobenzylcarbamate 66389-80-8