2,6-Difluorophenylboronic acid
- CAS No.
- 162101-25-9
- Chemical Name:
- 2,6-Difluorophenylboronic acid
- Synonyms
- 2,6-DIMETHOXYBENZENEBORONIC ACID;2,6-Difluorophenylboronic;AKOS BRN-0146;AKOS BRN-0261;CAS:162101-25-9;CHEMBRDG-BB 3200972;RARECHEM AH PB 0108;TIMTEC-BB SBB003736;RARECHEM AH PB 0164;2,6-Difluorophenylbo
- CBNumber:
- CB4853172
- Molecular Formula:
- C6H5BF2O2
- Molecular Weight:
- 157.91
- MDL Number:
- MFCD00792436
- MOL File:
- 162101-25-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 147-149 °C (lit.) |
|---|---|
| Boiling point | 260.1±50.0 °C(Predicted) |
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in methanol. |
| form | solid |
| pka | 8.12±0.58(Predicted) |
| color | White to Almost white |
| BRN | 8545931 |
| InChI | InChI=1S/C6H5BF2O2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3,10-11H |
| InChIKey | DBZAICSEFBVFHL-UHFFFAOYSA-N |
| SMILES | B(C1=C(F)C=CC=C1F)(O)O |
| CAS DataBase Reference | 162101-25-9(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2,6-Difluorophenylboronic acid price More Price(76)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 470791 | 2,6-Difluorophenylboronic acid 98% | 162101-25-9 | 1g | $40 | 2026-04-30 | Buy |
| Sigma-Aldrich | 470791 | 2,6-Difluorophenylboronic acid 98% | 162101-25-9 | 10g | $267 | 2026-04-30 | Buy |
| TCI Chemical | D3087 | 2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride) | 162101-25-9 | 1g | $23 | 2026-04-30 | Buy |
| TCI Chemical | D3087 | 2,6-Difluorophenylboronic Acid (contains varying amounts of Anhydride) | 162101-25-9 | 5g | $56 | 2026-04-30 | Buy |
| ChemScene | CS-W009261 | 2,6-Difluorophenylboronic acid ≥97% | 162101-25-9 | 5g | $9 | 2026-06-04 | Buy |
2,6-Difluorophenylboronic acid Chemical Properties, Uses, Production
Chemical Properties
White to off-white crystalline powder
Uses
suzuki reaction
Uses
Intermediates of Liquid Crystals
Uses
2,6-Difluorophenylboronic acid can be used:
- As a substrate in the model reaction of Suzuki–Miyaura coupling with4-chloro-3-methylanisole.
- To prepare 4-bromo-2,3′,5′,6-tetrafluorobiphenyl, a key intermediate for the synthesis of 2,6-difluorinated oligophenyls applicable in organic semiconductors.
- To prepare ethyl 4-(2,6-difluorophenyl)nicotinate, a key intermediate for the synthesis of 4-phenyl pyridine based potent TGR5 agonists.
Synthesis
121-43-7
372-18-9
162101-25-9
The general procedure for the synthesis of 2,6-difluorophenylboronic acid from trimethyl borate and 1,3-difluorobenzene was as follows: 22.8 g of 1,3-difluorobenzene (Compound I) and 150 mL of anhydrous ethyl ether were added to a 500 mL dry reaction flask under nitrogen protection and the system was cooled to -78 °C. Slowly 187 mL of 1.6 M n-butyllithium hexane solution was added dropwise to the mixture. After the dropwise addition was completed, the reaction was stirred at -60 to -70 °C for 2 hours. The system was again cooled to -78°C and 60 g of trimethyl borate was slowly added dropwise, and after the dropwise addition was completed, the reaction was stirred at a controlled temperature of -50 to -60°C for 2 hours. The reaction mixture was slowly warmed to room temperature, the reaction was quenched by the addition of 200 mL of water and acidified with 36% hydrochloric acid. After recovering the organic solvent by ascending distillation, the reaction mixture was stirred at 70 to 80 °C for 6 hours. Finally, the system was cooled to crystallization, filtered and washed with cold water to afford 27.0 g of 2,6-difluorophenylboronic acid (Compound II).
References
[1] Patent: CN103819401, 2016, B. Location in patent: Paragraph 0023; 0066; 0067
2,6-Difluorophenylboronic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SHANGHAI BANGCHENG CHEMICAL Co.,Ltd. | 021-69106960 13701823997 | 13701823733@163.com | China | 4634 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Latest Price from 2,6-Difluorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2,6-Difluorophenylboronic acid
162101-25-9
|
$1.20-34.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-06-27 | 2,6-Difluorophenylboronic acid
162101-25-9
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2025-06-20 | 2,6-Difluorophenylboronic acid
162101-25-9
|
$40.00 | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. |
-
- 2,6-Difluorophenylboronic acid
162101-25-9
- $1.20-34.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2,6-Difluorophenylboronic acid
162101-25-9
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2,6-Difluorophenylboronic acid
162101-25-9
- $40.00
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
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