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ChemicalBook >> CAS DataBase List >>6,7-Dihydro-5H-quinolin-8-one

6,7-Dihydro-5H-quinolin-8-one

6,7-Dihydro-5H-quinolin-8-one Structure
6,7-Dihydro-5H-quinolin-8-one structure
CAS No.
56826-69-8
Chemical Name:
6,7-Dihydro-5H-quinolin-8-one
Synonyms
6,7-DIHYDROQUINOLIN-8(5H)-ONE;6,7-DIHYDRO-5H-QUINOLINE-8-ONE;5,6,7,8-tetrahydroquinolin-8-one;in-8-one;AKOS BB-8709;6,7-Dihydro-5H-quinoL;6,7-DIHYDRO-5H-QUINOLIN-8-ONE;6,7-dihydro-1H-quinolin-8-one;8(5H)-Quinolinone, 6,7-dihydro-;5,6,7,8-Tetrahydro-8-quinolinone
CBNumber:
CB5123526
Molecular Formula:
C9H9NO
Molecular Weight:
147.17
MDL Number:
MFCD03839916
MOL File:
56826-69-8.mol
MSDS File:
SDS
Last updated:2026-05-28 02:15:02
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6,7-Dihydro-5H-quinolin-8-one Properties

Melting point 96-98 °C(Solv: isopropyl ether (108-20-3))
Boiling point 140 °C(Press: 0.1 Torr)
Density 1.168±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
form A crystalline solid
pka 3.46±0.20(Predicted)
Appearance light yellow-brown solid
InChI InChI=1S/C9H9NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h2,4,6H,1,3,5H2
InChIKey JIAKIQWNYAZUJD-UHFFFAOYSA-N
SMILES N1C2=C(CCCC2=O)C=CC=1
CAS DataBase Reference 56826-69-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P261-P280
HS Code  2933499090
NFPA 704
0
2 0

6,7-Dihydro-5H-quinolin-8-one price More Price(78)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 30480 6,7-Dihydro-5H-quinolin-8-one ≥98% 56826-69-8 500mg $42 2026-04-30 Buy
Cayman Chemical 30480 6,7-Dihydro-5H-quinolin-8-one ≥98% 56826-69-8 1g $60 2026-04-30 Buy
Cayman Chemical 30480 6,7-Dihydro-5H-quinolin-8-one ≥98% 56826-69-8 5g $183 2026-04-30 Buy
Usbiological 273632 6,7-Dihydro-5H-Quinolin-8-one Asreported 56826-69-8 1g $340 2026-06-03 Buy
Usbiological 273632 6,7-Dihydro-5H-Quinolin-8-one Asreported 56826-69-8 2g $489 2026-06-03 Buy
Product number Packaging Price Buy
30480 500mg $42 Buy
30480 1g $60 Buy
30480 5g $183 Buy
273632 1g $340 Buy
273632 2g $489 Buy

6,7-Dihydro-5H-quinolin-8-one Chemical Properties, Uses, Production

Description

6,7-Dihydro-5H-quinolin-8-one is a synthetic intermediate. It has been used in the synthesis of tetrahydropyridoazepinones and thiosemicarbazones with anticancer activity.

Chemical Properties

light yellow crystalline

Uses

6,7-Dihydroquinolin-8(5H)-one is a synthetic intermediate useful for pharmaceutical synthesis.

Synthesis Reference(s)

The Journal of Organic Chemistry, 49, p. 2208, 1984 DOI: 10.1021/jo00186a027
Synthetic Communications, 33, p. 3497, 2003 DOI: 10.1081/SCC-120024729

Synthesis

5,6,7,8-Tetrahydroquinolin-8-ol

14631-46-0

6,7-Dihydro-5H-quinolin-8-one

56826-69-8

Preparation of 6,7-dihydro-5H-quinolin-8-one: 8-hydroxy-5,6,7,8-tetrahydroquinoline (13.96 g, 93.6 mmol) was dissolved in anhydrous dichloromethane (400 mL) under stirring conditions. Subsequently, activated manganese dioxide (85% pure, 82.22 g, 804 mmol) was added to this solution. The resulting non-homogeneous mixture was stirred for 18 hours. Upon completion of the reaction, the black slurry was filtered through a diatomaceous earth filter cake and the cake was washed with dichloromethane (3 x 50 mL). The washes were combined and concentrated to afford 11.27 g (82% yield) of the target product, 6,7-dihydro-5H-quinolin-8-one, as a light yellow solid, which could be used in subsequent reactions without further purification. The structure of the product was characterized by 1H NMR (CDCl3) δ 2.17-2.25 (m, 2H), 2.82 (t, 2H, J = 7 Hz), 3.04 (t, 2H, J = 6 Hz), 7.37 (dd, 1H, J = 9,6 Hz), 7.66 (dd, 1H, J = 9,1 Hz), 8.71 (dd, 1H, J = 6,1 Hz); 13C NMR (CDCl3) δ 22.2, 28.6, 39.2, 126.6, 137.3, 140.5, 147.6, 148.6, 196.5 confirmed.ES-MS m/z 148 (M + H) further validated the product structure.

References

[1] Patent: US2003/220341, 2003, A1. Location in patent: Page/Page column 9
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 213 - 220
[3] Patent: US2004/19058, 2004, A1

6,7-Dihydro-5H-quinolin-8-one Preparation Products And Raw materials

Raw materials

5,6,7,8-Tetrahydroquinolin-8-ol Dichloromethane Manganese dioxide

Preparation Products

6,7-Dihydro-5H-quinolin-8-one Suppliers

Global Suppliers ( 201)
Supplier Tel Email Country ProdList Advantage
Changzhou Langyi Biomedical Technology Co., Ltd. 13706129682 tiffany@langyupharm.com China 90 58
Zhengzhou Alfachem Co.,Ltd. 0371-53778726 18003825608 liuxiaoyan@alfachem.cn China 1971 58
Shanghai Birch Chemical Technology Co., Ltd. 021-54096810 18017263450 sales@birchchem.com China 500 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Supplier Advantage
Changzhou Langyi Biomedical Technology Co., Ltd. 58
Zhengzhou Alfachem Co.,Ltd. 58
Shanghai Birch Chemical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64

View Latest Price from 6,7-Dihydro-5H-quinolin-8-one manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6,7-Dihydro-5H-quinolin-8-one pictures 2026-08-25 6,7-Dihydro-5H-quinolin-8-one
56826-69-8
 $1.10-9.90 1KG 99% min 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
6,7-Dihydro-5H-quinolin-8-one pictures 2026-08-20 6,7-Dihydro-5H-quinolin-8-one
56826-69-8
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited
6,7-Dihydro-5H-quinolin-8-one pictures 2026-05-11 6,7-Dihydro-5H-quinolin-8-one
56826-69-8
 $137.00 10g TargetMol Chemicals Inc.

6,7-Dihydro-5H-quinolin-8-one Spectrum

6,7-Dihydro-5H-quinolin-8-one(56826-69-8)1HNMR6,7-Dihydro-5H-quinolin-8-one(56826-69-8)FT-IR

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AKOS BB-8709 6,7-DIHYDRO-5H-QUINOLIN-8-ONE 6,7-DIHYDRO-5H-QUINOLIN-8-ONE,99+% 6,7-dihydro-5H-quinolin-8-one98%+, 5,6,7,8-tetrahydroquinolin-8-one 8(5H)-Quinolinone, 6,7-dihydro- 8-oxo-5,6,7,8-tetrahydroquinoline 5,6,7,8-Tetrahydro-8-quinolinone 6,7-Dihydro-5H-Quinolin-8-One(WX625030) 56826-69-86,7-Dihydro-5H-quinolin-8-one 6,7-Dihydro-5H-quinoL in-8-one 6,7-dihydro-1H-quinolin-8-one 6,7-Dihydro-5H-quinolin-8-one ISO 9001：2015 REACH TIANFUCHEM--56826-69-8--High purity 6,7-Dihydro-5H-quinolin-8-one factory price 6,7-DIHYDRO-5H-QUINOLINE-8-ONE 6,7-DIHYDROQUINOLIN-8(5H)-ONE 56826-69-8 Quinoline Derivertives Heterocycles Heterocyclic Compound