2,6-Difluoro-3-nitropyridine
- CAS No.
- 58602-02-1
- Chemical Name:
- 2,6-Difluoro-3-nitropyridine
- Synonyms
- 6-difluoro-3-nitropyridine;2,6-Difluor-3-nitropyridin;3-Nitro-2,6-difluoropyridine;2,6-Difluoro-5-nitropyridine;2,6-Difluoro-3-nitropyridine;PYRIDINE, ,26-DIFLUORO-3-NITRO-
- CBNumber:
- CB51471084
- Molecular Formula:
- C5H2F2N2O2
- Molecular Weight:
- 160.08
- MDL Number:
- MFCD11044323
- MOL File:
- 58602-02-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P271-P260-P280 |
| HS Code | 2933399990 |
2,6-Difluoro-3-nitropyridine price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC50087 | 2,6-Difluoro-3-nitropyridine ≥95% | 58602-02-1 | 250mg | $55 | 2026-06-04 | Buy |
| Matrix Scientific | 091594 | 2,6-Difluoro-3-nitropyridine | 58602-02-1 | 5.00g | $355 | 2026-05-18 | Buy |
| Matrix Scientific | 091594 | 2,6-Difluoro-3-nitropyridine | 58602-02-1 | 25.00g | $865 | 2026-05-18 | Buy |
| Synthonix | D67347 | 2,6-Difluoro-3-nitropyridine >98% | 58602-02-1 | 5g | $60 | 2026-05-06 | Buy |
| Synthonix | D67347 | 2,6-Difluoro-3-nitropyridine >98% | 58602-02-1 | 10g | $80 | 2026-05-06 | Buy |
2,6-Difluoro-3-nitropyridine Chemical Properties, Uses, Production
Preparation
Interestingly, direct nitration of 2-fluoro and 2,6-difluoropyridine with nitronium tetrafluoroborate achieved a degree of success and whilst 2-fluoropyridine gave mostly the N-nitro salt, a 6% yield of 5-nitro-2-fluoropyridine was obtained and 2,6-difluoropyridine gave a 20% yield of 3-nitro-2,6-difluoropyridine.
Synthesis
16013-85-7
58602-02-1
The general procedure for the synthesis of 2,6-difluoro-3-nitropyridine from 2,6-dichloro-3-nitropyridine was as follows: 3-bromo-2,6-dichloropyridine (4.70 g, 20.7 mmol) was dissolved in DMSO (103 mL) at room temperature, followed by the addition of cesium fluoride (12.6 g, 82.9 mmol). The reaction mixture was stirred at 80°C for 8 hours in air. After completion of the reaction, the mixture was poured into water and extracted with ether (Et2O). The organic layer was separated, washed sequentially with water and brine, dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure (400 Torr, 40°C). The residue was purified by silica gel column chromatography using ethyl acetate (EtOAc) solution in hexane as eluent to afford 3-bromo-2,6-difluoropyridine (3B) as a colorless oil (2.58 g, 64% yield). Its nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) data were as follows: δ 6.79 (1H, dd, J = 8.3, 3.0 Hz), 8.03 (1H, ddd, J = 8.4, 8.4, 7.0 Hz). Nuclear Magnetic Resonance Fluorine Spectroscopy (19F NMR, CDCl3) data: δ -69.3 Hz, -63.8 Hz. compounds 4B to 8B were prepared similarly as described for 3B.
References
[1] Collection of Czechoslovak Chemical Communications, 1991, vol. 56, # 11.1, p. 2420 - 2429
[2] Tetrahedron Letters, 2015, vol. 56, # 44, p. 6043 - 6046
2,6-Difluoro-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Difluoro-3-nitropyridine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Shanghai potentpharm CO.,Ltd | (86) 21 51969655 | China | 486 | 22 | |
| shanghai aokchem co., ltd | 021-68712331 39130253 | aokchem@gmail.com | China | 332 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Xiamen Dano Pharmaceutical Co., LTD(China) | 0592-6266840 15750707980; | chemdano@126.com | China | 411 | 57 |
View Latest Price from 2,6-Difluoro-3-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-23 | 2,6-Difluoro-3-nitropyridine
58602-02-1
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- 2,6-Difluoro-3-nitropyridine
58602-02-1
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
