2-Fluoro-5-nitropyridine
- CAS No.
- 456-24-6
- Chemical Name:
- 2-Fluoro-5-nitropyridine
- Synonyms
- uoro-5-nitropyridine;6-FLUORO-3-NITROPYRIDINE;2-FLUORO-5-NITROPYRIDINE;Pyridine, 2-fluoro-5-nitro-;2-Fluoro-5-nitropyridine >2-Fluoro-5-nitropyridine ISO 9001：2015 REACH
- CBNumber:
- CB8239783
- Molecular Formula:
- C5H3FN2O2
- Molecular Weight:
- 142.09
- MDL Number:
- MFCD03095059
- MOL File:
- 456-24-6.mol
| Product description | Number | Pack Size | Price |
| 2-Fluoro-5-nitropyridine >98.0%(GC) | F0983 | 5g | $26 |
| 2-Fluoro-5-nitropyridine >98.0%(GC) | F0983 | 25g | $103 |
| 2-Fluoro-5-nitropyridine | F597683 | 1g | $75 |
| 2-Fluoro-5-nitropyridine | N398 | 25g | $94 |
| 2-Fluoro-5-nitropyridine | 4H54-3-52 | 25g | $100 |
| More product size | |||
| Melting point | 142-144 C |
|---|---|
| Boiling point | 86-87℃/7mm lit. |
| Density | 4,64g/cm |
| refractive index | 1.5250 |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Liquid |
| pka | -4.47±0.10(Predicted) |
| color | Colorless to pale yellow |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C5H3FN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H |
| InChIKey | XOZAJNLUAODXSP-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=C([N+]([O-])=O)C=C1 |
| CAS DataBase Reference | 456-24-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H302 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | UN 1549 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2-Fluoro-5-nitropyridine price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0983 | 2-Fluoro-5-nitropyridine >98.0%(GC) | 456-24-6 | 5g | $26 | 2025-07-31 | Buy |
| TCI Chemical | F0983 | 2-Fluoro-5-nitropyridine >98.0%(GC) | 456-24-6 | 25g | $103 | 2025-07-31 | Buy |
| TRC | F597683 | 2-Fluoro-5-nitropyridine | 456-24-6 | 1g | $75 | 2021-12-16 | Buy |
| AK Scientific | N398 | 2-Fluoro-5-nitropyridine | 456-24-6 | 25g | $94 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H54-3-52 | 2-Fluoro-5-nitropyridine | 456-24-6 | 25g | $100 | 2021-12-16 | Buy |
2-Fluoro-5-nitropyridine Chemical Properties,Uses,Production
Uses
It is used in the preparation of nitropyridines by nitration of pyridines with nitric acid.
Uses
2-Fluoro-5-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
Synthesis of 5-amino-2-fluoropyridine. A mixture of 5-nitro-2-chloropyridine (2.0 g, 12.6 mmol) and anhydrous potassium fluoride (2.2 g, 38 mmol) in a combination of sulfalone ( 6 mL) and benzene (4 mL) was stirred at RT for 20 min. The benzene was then removed by distillation. The resulting mixture was heated at 150 ??C for 12h. The mixture was cooled to RT whereupon water (60 mL) was added. The desired product was separated from the solution via steam distillation. Extraction of the distillate with diethyl ether (2 ?á 1 0 mL) followed by drying (Na2SO4) and concentration gave the compound. 5-nitro-2-fluoropyridine, water white oil (1.3 g, 73%).
References
[1] Chemistry Letters, 1993, # 3, p. 509 - 512
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 6, p. 1411 - 1416
[3] Patent: US6355636, 2002, B1. Location in patent: Page column 64
[4] Patent: EP1171440, 2004, B1. Location in patent: Page 53
[5] Tetrahedron, 1980, vol. 36, p. 1931 - 1936
2-Fluoro-5-nitropyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; +8619817745290 | bd@blocksynth.com | China | 5661 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20138 | 58 |
| Frapp's ChemicalNFTZ Co., Ltd. | +86 (576) 8169-6106 | sales@frappschem.com | China | 880 | 50 |
| Hi-Tech Chemistry Corp | 0519-86626038 | yuhh@hitechem.com | CHINA | 810 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21614 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29847 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
View Lastest Price from 2-Fluoro-5-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-11-18 | 2-Fluoro-5-nitropyridine
456-24-6
|
US $1.10 / g | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-09-25 | 2-Fluoro-5-nitropyridine
456-24-6
|
US $5.00-0.10 / KG | 1KG | 98% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-07-25 | 2-Fluoro-5-nitropyridine
456-24-6
|
US $0.00-0.00 / KG | 1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Fluoro-5-nitropyridine
456-24-6
- US $1.10 / g
- 99.00%
- Dideu Industries Group Limited
-
- 2-Fluoro-5-nitropyridine
456-24-6
- US $5.00-0.10 / KG
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluoro-5-nitropyridine
456-24-6
- US $0.00-0.00 / KG
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
