2-Fluoro-5-nitropyridine
- CAS No.
- 456-24-6
- Chemical Name:
- 2-Fluoro-5-nitropyridine
- Synonyms
- uoro-5-nitropyridine;6-FLUORO-3-NITROPYRIDINE;2-FLUORO-5-NITROPYRIDINE;Pyridine, 2-fluoro-5-nitro-;2-Fluoro-5-nitropyridine >Perfluorooctapentacontanoic acid;2-Fluoro-5-nitropyridine ISO 9001：2015 REACH
- CBNumber:
- CB8239783
- Molecular Formula:
- C5H3FN2O2
- Molecular Weight:
- 142.09
- MDL Number:
- MFCD03095059
- MOL File:
- 456-24-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 142-144 C |
|---|---|
| Boiling point | 86-87℃/7mm lit. |
| Density | 4,64g/cm |
| refractive index | 1.5250 |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Liquid |
| pka | -4.47±0.10(Predicted) |
| color | Colorless to pale yellow |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Moisture Sensitive |
| InChI | InChI=1S/C5H3FN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H |
| InChIKey | XOZAJNLUAODXSP-UHFFFAOYSA-N |
| SMILES | C1(F)=NC=C([N+]([O-])=O)C=C1 |
| CAS DataBase Reference | 456-24-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H302 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-22 | |||||||||
| Safety Statements | 36 | |||||||||
| RIDADR | UN 1549 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2-Fluoro-5-nitropyridine price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0983 | 2-Fluoro-5-nitropyridine >98.0%(GC) | 456-24-6 | 5g | $28 | 2026-04-30 | Buy |
| TCI Chemical | F0983 | 2-Fluoro-5-nitropyridine >98.0%(GC) | 456-24-6 | 25g | $112 | 2026-04-30 | Buy |
| Apolloscientific | PC48306 | 2-Fluoro-5-nitropyridine 97% | 456-24-6 | 25g | $73 | 2026-06-04 | Buy |
| Activate Scientific | AS23161 | 2-Fluoro-5-nitropyridine 98% | 456-24-6 | 5g | $23 | 2026-06-04 | Buy |
| Activate Scientific | AS23161 | 2-Fluoro-5-nitropyridine 98% | 456-24-6 | 25g | $33 | 2026-06-04 | Buy |
2-Fluoro-5-nitropyridine Chemical Properties,Uses,Production
Uses
It is used in the preparation of nitropyridines by nitration of pyridines with nitric acid.
Uses
2-Fluoro-5-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
Synthesis of 5-amino-2-fluoropyridine. A mixture of 5-nitro-2-chloropyridine (2.0 g, 12.6 mmol) and anhydrous potassium fluoride (2.2 g, 38 mmol) in a combination of sulfalone ( 6 mL) and benzene (4 mL) was stirred at RT for 20 min. The benzene was then removed by distillation. The resulting mixture was heated at 150 C for 12h. The mixture was cooled to RT whereupon water (60 mL) was added. The desired product was separated from the solution via steam distillation. Extraction of the distillate with diethyl ether (2 á 1 0 mL) followed by drying (Na2SO4) and concentration gave the compound. 5-nitro-2-fluoropyridine, water white oil (1.3 g, 73%).
References
[1] Chemistry Letters, 1993, # 3, p. 509 - 512
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 6, p. 1411 - 1416
[3] Patent: US6355636, 2002, B1. Location in patent: Page column 64
[4] Patent: EP1171440, 2004, B1. Location in patent: Page 53
[5] Tetrahedron, 1980, vol. 36, p. 1931 - 1936
2-Fluoro-5-nitropyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| JIANGYIN RUISHIPHARM CO.,LIMITED | 0510-0510-66227179 18921203887 | sales@ruishipharm.com | China | 747 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
View Lastest Price from 2-Fluoro-5-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Fluoro-5-nitropyridine
456-24-6
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2-Fluoro-5-nitropyridine
456-24-6
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2026-06-30 | 2-Fluoro-5-nitropyridine
456-24-6
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Fluoro-5-nitropyridine
456-24-6
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluoro-5-nitropyridine
456-24-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Fluoro-5-nitropyridine
456-24-6
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
