2,6-Dichloro-3-nitropyridine
- CAS No.
- 16013-85-7
- Chemical Name:
- 2,6-Dichloro-3-nitropyridine
- Synonyms
- 6-Dichloro-3-nitropyridine;PYRIDINE, 2,6-DICHLORO-3-NITRO-;26DC3NP;TIMTEC-BB SBB003614;2,6-Dichloro-3-nitro;Flupirtine Impurity H;DICHLORONITROPYRIDINE;Dichloro-3-nitropyrid;2,6-DICHLORO-3-NITROPYRIDINE;2,6-Dichloro-3-nitropyrid...
- CBNumber:
- CB8130660
- Molecular Formula:
- C5H2Cl2N2O2
- Molecular Weight:
- 192.99
- MDL Number:
- MFCD00006234
- MOL File:
- 16013-85-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 55-60 °C(lit.) |
|---|---|
| Boiling point | 295.5±35.0 °C(Predicted) |
| Density | 1.6791 (rough estimate) |
| refractive index | 1.6100 (estimate) |
| Flash point | >230 °F |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | Liquid |
| pka | -5.76±0.10(Predicted) |
| color | Clear colorless to light yellow |
| BRN | 1619741 |
| InChI | InChI=1S/C5H2Cl2N2O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H |
| InChIKey | SHCWQWRTKPNTEM-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC=C1[N+]([O-])=O |
| CAS DataBase Reference | 16013-85-7(CAS DataBase Reference) |
| FDA UNII | KH7F529L8W |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H317-H319-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-42/43-43 | |||||||||
| Safety Statements | 22-26-36/37-37/39-24-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2,6-Dichloro-3-nitropyridine price More Price(85)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 193585 | 2,6-Dichloro-3-nitropyridine technical grade, 92% | 16013-85-7 | 10g | $40 | 2023-01-07 | Buy |
| TCI Chemical | D2761 | 2,6-Dichloro-3-nitropyridine >98.0%(GC) | 16013-85-7 | 5g | $24 | 2026-04-30 | Buy |
| TCI Chemical | D2761 | 2,6-Dichloro-3-nitropyridine >98.0%(GC) | 16013-85-7 | 25g | $71 | 2026-04-30 | Buy |
| Usbiological | 160001 | 2,6-Dichloro-3-nitropyridine | 16013-85-7 | 25g | $403 | 2026-06-03 | Buy |
| Biosynth | FD00177 | 2,6-Dichloro-3-nitropyridine | 16013-85-7 | 0.1kg | $150 | 2026-06-04 | Buy |
2,6-Dichloro-3-nitropyridine Chemical Properties, Uses, Production
Chemical Properties
yellow crystalline powder or chunks
Uses
2,6-Dichloro-3-nitropyridine was used:
- in the synthesis of pyridyldifluoroacetates
- as starting reagent in the preparation of bicyclooxacalixhetarene
Uses
2,6-Dichloro-3-nitropyridine is a starting compound for the synthesis of a sulfide analog of Flupirtine with KV7.2/3 channel opening activity. 2,6-Dichloro-3-nitropyridine can be used in pain research.
Definition
Nitropyridine nucleus played a pivotal role in the development of different medicinal agents and in the field of agrochemicals. It is seen from the current literature that pyridine derivatives have been developed and used as insecticidal agents. Nitrated pyridines and their derivatives are important intermediates in synthesis of heterocyclic compounds in dyes and pharmaceutical products. Fused heterocycles containing nitropyridine systems have been associated with several biological and medicinal activities including antiolytic, antiviral and anti-inflammatory profiles.
General Description
2,6-Dichloro-3-nitropyridine undergoes macrocyclic condensation reaction with resorcinol derivatives to yield chiral tetraoxacalix[2]arene[2]pyridines.
Synthesis
2402-78-0
16013-85-7
General procedure for the synthesis of 2,6-dichloro-3-nitropyridine from 2,6-dichloropyridine: 80 mL of concentrated sulfuric acid was added to a 150 mL three-necked flask with stirring at room temperature, and 7.4 g (0.05 mol) of 2,6-dichloropyridine (IV) was slowly added, followed by the slow addition of 10.1 g (0.1 mol) of potassium nitrate. After the addition was completed, stirring was continued for 30 minutes, then the temperature was slowly increased to 120°C and the reaction was maintained at this temperature for 10 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and poured into crushed ice with stirring. The precipitated white solid precipitate was washed to neutrality with ice water, immediately subjected to diafiltration, and dried to give 7.75 g of white solid 2,6-dichloro-3-nitropyridine (V) in 80% yield and melting point of 61-63 °C.
Structure and conformation
The asymmetric unit of 2,6-Dichloro-3-nitropyridine consists of two crystallographically independent mol-ecules. The pyridine ring in each mol-ecule is essentially planar, with maximum deviations of 0.004 (4) and 0.007 (4)Å. Short Cl-O [3.09(3) and 3.13 (4)Å] and Cl-Cl [3.38 (12)Å] contacts were observed. No significant inter-molecular inter-actions were observed in the crystal packing.
References
[1] Patent: CN103936766, 2016, B. Location in patent: Paragraph 0032-0033
[2] Patent: US2006/80790, 2006, A1. Location in patent: Page/Page column 2
[3] Patent: WO2017/31176, 2017, A1. Location in patent: Page/Page column 33-34
[4] Journal of Heterocyclic Chemistry, 1984, vol. 21, # 5, p. 1521 - 1525
[5] ChemMedChem, 2015, vol. 10, # 2, p. 368 - 379
2,6-Dichloro-3-nitropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Taijilin Industrial Co., Ltd. | 02150630626 17717886015 | kate@tajilin.com | China | 1341 | 58 |
| Jinan Dexinjia Bio&Tech Co., Ltd | 0531-82375880 15098789112 | 3845379039@qq.com | China | 1457 | 58 |
| Shanghai Rolead Chemical Technology Co., Ltd. | 021-69992220 13701886816 | roleadchem@163.com | China | 4602 | 50 |
| Ningbo jinuo chemical co., LTD | 0574-87314919 057487319282 | info@nbinno.com | China | 7046 | 58 |
| Shanghai Jinsheng Pharmaceutical Co., Ltd. | 1365-13651960330 13651960330 | xiangfeixia@jspharmatech.com | China | 401 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
View Latest Price from 2,6-Dichloro-3-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | 2,6-Dichloro-3-nitropyridine
16013-85-7
|
25Kg/Drum | 98.00%HPLC | 9tons/month | Asia Chem I and E (Jiangsu) Co Ltd | ||
 |
2026-08-20 | 2,6-Dichloro-3-nitropyridine
16013-85-7
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2025-11-12 | 2,6-Dichloro-3-nitropyridine
16013-85-7
|
1kg | 98% | 15 | Zhengzhou Lingzhiyue Technology Co., Ltd |
-
- 2,6-Dichloro-3-nitropyridine
16013-85-7
- $0.00
- 98.00%HPLC
- Asia Chem I and E (Jiangsu) Co Ltd
-
- 2,6-Dichloro-3-nitropyridine
16013-85-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2,6-Dichloro-3-nitropyridine
16013-85-7
- 98%
- Zhengzhou Lingzhiyue Technology Co., Ltd
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