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N-Cbz-Hydroxy-L-proline

N-Cbz-Hydroxy-L-proline structure

CAS No.: 13504-85-3

Chemical Name:: N-Cbz-Hydroxy-L-proline

Synonyms: CBZ-L-HYDROXYPROLINE;(2S,4R)-1-((benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;Z-HYP-OH;CBZ-HYP-OH;Z-Hyp;Z-L-HYP-OH;CBZ-L-HYP-OH;-4-hydroxy-L;Z-HYP(BZL)-OH;Z-HYDROXYPROLINE

CBNumber:: CB5148552

Molecular Formula:: C13H15NO5

Molecular Weight:: 265.26

MDL Number:: MFCD00037329

MOL File:: 13504-85-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:20:29

Product description	Number	Pack Size	Price
Z-Hyp-OH ≥99.0% (T)	96310	25g	$99.4
Z-Hyp-OH ≥99.0% (T)	96310	5g	$79
trans-N-Carbobenzoxy-4-hydroxy-L-proline >98.0%(HPLC)(T)	C2506	5g	$24
trans-N-Carbobenzoxy-4-hydroxy-L-proline >98.0%(HPLC)(T)	C2506	25g	$123
(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylicAcid1-BenzylEster	H953385	5g	$70
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N-Cbz-Hydroxy-L-proline Properties

Melting point	104-107 °C
Boiling point	486.9±45.0 °C(Predicted)
Density	1.416±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Dichloromethane, Ethyl Acetate
pka	3.78±0.40(Predicted)
form	Oil
color	White to off-white
optical activity	[α]20/D 54±1°, c = 2% in ethanol
Water Solubility	Slightly soluble in water.
BRN	90295
Major Application	peptide synthesis
InChI	1S/C13H15NO5/c15-10-6-11(12(16)17)14(7-10)13(18)19-8-9-4-2-1-3-5-9/h1-5,10-11,15H,6-8H2,(H,16,17)/t10-,11+/m1/s1
InChIKey	WWVCWLBEARZMAH-MNOVXSKESA-N
SMILES	O[C@@H]1C[C@H](N(C1)C(=O)OCc2ccccc2)C(O)=O
CAS DataBase Reference	13504-85-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

PPE

Eyeshields, Gloves, type N95 (US)

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

N-Cbz-Hydroxy-L-proline price More Price(46)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	96310	Z-Hyp-OH ≥99.0% (T)	13504-85-3	25g	$99.4	2025-07-31	Buy
Sigma-Aldrich	96310	Z-Hyp-OH ≥99.0% (T)	13504-85-3	5g	$79	2023-06-20	Buy
TCI Chemical	C2506	trans-N-Carbobenzoxy-4-hydroxy-L-proline >98.0%(HPLC)(T)	13504-85-3	5g	$24	2025-07-31	Buy
TCI Chemical	C2506	trans-N-Carbobenzoxy-4-hydroxy-L-proline >98.0%(HPLC)(T)	13504-85-3	25g	$123	2025-07-31	Buy
TRC	H953385	(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylicAcid1-BenzylEster	13504-85-3	5g	$70	2021-12-16	Buy

Product number	Packaging	Price	Buy
96310	25g	$99.4	Buy
96310	5g	$79	Buy
C2506	5g	$24	Buy
C2506	25g	$123	Buy
H953385	5g	$70	Buy

N-Cbz-Hydroxy-L-proline Chemical Properties,Uses,Production

Chemical Properties

Viscous Oil

Uses

A competitive inhibitor of porcine kidney prolidase.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

501-53-1

51-35-4

13504-85-3

GENERAL METHOD: To a solution of L-hydroxyproline (78.7 g, 600 mmol) and sodium bicarbonate (126 g, 1.5 mol) in water (900 mL), a solution of benzyl chloroformate (89.6 mL, 630 mmol) in dioxane (90 mL) was slowly added. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction (monitored by thin-layer chromatography), the reaction mixture was cooled to 0 °C in an ice bath and acidified to pH 2 with 12 M hydrochloric acid (about 75 mL was required). Subsequently, the aqueous phase was extracted with ethyl acetate (3 × 500 mL), the organic phases were combined and washed with saturated brine (3 × 200 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a colorless viscous oil. The yield was quantitative, and the product could be directly used in the next reaction without further purification.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 16, p. 1845 - 1847
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 47, p. 9073 - 9077
[3] Patent: EP1193270, 2002, A2. Location in patent: Page 14, 35-36, 105
[4] Tetrahedron Letters, 2016, vol. 57, # 44, p. 4882 - 4884
[5] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 5, p. 575 - 580

N-Cbz-Hydroxy-L-proline synthesis

Synthesis of N-Cbz-Hydroxy-L-proline from Benzyl chloroformate and cis-4-Hydroxy-D-proline

N-Cbz-Hydroxy-L-proline Preparation Products And Raw materials

Raw materials

Benzyl chloroformate L-Hydroxyproline cis-4-Hydroxy-D-proline 1,4-Dioxane Sodium bicarbonate

Water

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Preparation Products

2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- N-BOC-cis-4-fluoro-L-proline (2S,4R)-1-((benzyloxy)carbonyl)-4-methoxypyrrolidine-2-carboxylic acid Z-TRANS-4-HYDROXY-L-PROLINOL

N-Cbz-Hydroxy-L-proline Suppliers

Global( 346)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10000	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from N-Cbz-Hydroxy-L-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-01-30	N-Cbz-Hydroxy-L-proline 13504-85-3	US $10.00 / KG	1KG	99%	5tons	Hebei Chuanghai Biotechnology Co., Ltd
2024-04-28	Z-Hyp-OH 13504-85-3	US $5.00 / kg	1kg	99.92%	50000tons	Ouhuang Engineering Materials (Hubei) Co., Ltd
2022-01-26	Z-Hyp-oh 13504-85-3	US $0.00 / KG	1KG	98.3%	100 tons	Honest Joy Holdings Limited

N-Cbz-Hydroxy-L-proline
13504-85-3
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Z-Hyp-OH
13504-85-3
US $5.00 / kg
99.92%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Z-Hyp-oh
13504-85-3
US $0.00 / KG
98.3%
Honest Joy Holdings Limited

N-Cbz-Hydroxy-L-proline Spectrum

N-Cbz-Hydroxy-L-proline(13504-85-3)¹HNMR

13504-85-3(N-Cbz-Hydroxy-L-proline)Related Search:

L-Proline Trimethoprim CHLOROPHOSPHONAZO III CARBONYL SULFIDE D-Proline

Nequinate L-PROLINE-(4-3H(N)) N-CBZ-HYDROXY-L-PROLINE METHYL ESTER H-D-CIS-HYP-OH Z-ILE-LEU-OH

N-CARBOBENZOXY-L-ISOLEUCINE DICYCLOHEXYLAMMONIUM SALT Z-TRANS-4-HYDROXY-L-PROLINOL Z-Hyp(tBu)-OMe Cbz-N-methyl-L-phenylalanine Z-ARG(NO2)-OH

N-Benzyloxycarbonyl-L-asparagine N-alpha-Cbz-L-lysine Z-D-GLN-OH

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(2S,4R)-N-Cbz-trans-4-hydroxy-L-proline Z-L-HYP-OH Z-L-4-HYDROXYPROLINE Z-L-4-TRANS-HYDROXYPROLINE TRANS-N-ALPHA-BENZYLOXYCARBONYL-L-HYDROXYPROLINE BENZYLOXYCARBONYL-L-4-HYDROXYPROLINE CBZ-HYP-OH CBZ-L-HYDROXYPROLINE CBZ-L-HYP-OH N-Carbobenzyloxy-4-hydroxy-L-proline (trans) N-Z-4-hydroxy-L-proline (trans) 1-benzyl hydrogen (2S-trans)-4-hydroxypyrrolidine-1,2-dicarboxylate Z-trans-4-hydroxy-L-proline N-Cbz-cis-4-hydroxy-D-proline (2R,4R)-N-CBZ-4-HYDROXY-D-PROLINE Cbz-L-4- Hydroxyproline N-Benzyloxycarbonyl-4-hydroxy-L-proline N-Benzyloxycarbonyl-L-Hydroproline N-CARBOBENZYLOXY-TRANS-4-HYDROXY-L-PROLINE N-CBZ-CIS-4-HYDROXY-L-PROLINE CBZ-TRANS-4-HYDROXY-L-PROLINE Z-L-HYDROXYPROLINE extrapure N-carbobenzyloxy-hydroxy-L-proline N-Cbz-Hydroxy-L-proline, Z-L-4-Hydroxyproline (2S)-1-(Benzyloxycarbonyl)-4β-hydroxypyrrolidine-2α-carboxylic acid (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid hydrogen 1-(phenylmethyl) ester (4R)-1-(Benzyloxycarbonyl)-4-hydroxy-L-proline (4R)-N-(Benzyloxycarbonyl)-4-hydroxy-L-proline 1-(Benzyloxycarbonyl)-trans-4-hydroxy-L-proline N-(Benzyloxycarbonyl)-trans-4-hydroxy-L-proline Z-Hyp (2R)-2-hydroxy-1-phenylmethoxycarbonyl-2-pyrrolidinecarboxylic acid N-ALPHA-CARBOBENZOXY-L-HYDROXYPROLINE N-ALPHA-CARBOBENZOXY-O-BENZYL-TRANS-4-HYDROXY-L-PROLINE N-ALPHA-CBZ-L-4-TRANS-HYDROXYPROLINE N-ALPHA-BENZYLOXYCARBONYL-TRANS-L-HYDROXYPROLINE N-ALPHA-CARBOBENZOXY-(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID N-CARBOBENZOXY-L-HYDROXYPROLINE N-CBZ-HYDROXY-L-PROLINE Z-4-HYDROXY-L-PROLINE Z-HYP(BZL)-OH Z-HYP-OH Z-HYDROXYPROLINE Z-L-HYDROXYPROLINE N-carbobenzyloxy-4-hydroxy-l-proline 1-(benzyloxycarbonyl)-4-hydroxy-proline 4-hydroxy-1-(phenylmethoxycarbonyl)pyrrolidine-2-carboxylic acid N-Cbz-Hydroxy-L-prol (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, N-CBZ protected trans-4-Hydroxy-L-proline, N-CBZ protected 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(phenylMethyl) ester, (2S,4R)- trans-N-Carbobenzoxy-4-hydroxy-L-proline trans-N-Cbz-4-hydroxy-L-proline Z-Hyp-OH (2S,4R)-1-((benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-Benzyl Ester N-CBZ-4-hydroxy-L-proline Z-Hyp-OH >=99.0% (T) Z-L-4-trans-hydroxyproline≥ 98% (HPLC)