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N-Cbz-Hydroxy-L-proline

N-Cbz-Hydroxy-L-proline structure

CAS No.: 13504-85-3

Chemical Name:: N-Cbz-Hydroxy-L-proline

Synonyms: Z-HYP-OH;CBZ-HYP-OH;(2S,4R)-1-((benzyloxy)carbonyl)-4-hydroxypyrrolidine-2-carboxylic acid;CBZ-L-HYDROXYPROLINE;Z-Hyp;N-Cbz-Hydroxy-L-prol;1-(Phenylmethyl) (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate;Cbz-Hyp;Z-L-HYP-OH;CBZ-L-HYP-OH

CBNumber:: CB5148552

Molecular Formula:: C13H15NO5

Molecular Weight:: 265.26

MDL Number:: MFCD00037329

MOL File:: 13504-85-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:55:28

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N-Cbz-Hydroxy-L-proline Properties

Melting point	104-107 °C
Boiling point	486.9±45.0 °C(Predicted)
Density	1.416±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Dichloromethane, Ethyl Acetate
form	Oil
pka	3.78±0.40(Predicted)
color	White to off-white
optical activity	[α]20/D 54±1°, c = 2% in ethanol
Water Solubility	Slightly soluble in water.
BRN	90295
Major Application	peptide synthesis
InChI	1S/C13H15NO5/c15-10-6-11(12(16)17)14(7-10)13(18)19-8-9-4-2-1-3-5-9/h1-5,10-11,15H,6-8H2,(H,16,17)/t10-,11+/m1/s1
InChIKey	WWVCWLBEARZMAH-MNOVXSKESA-N
SMILES	O[C@@H]1C[C@H](N(C1)C(=O)OCc2ccccc2)C(O)=O
CAS DataBase Reference	13504-85-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

PPE

Eyeshields, Gloves, type N95 (US)

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

N-Cbz-Hydroxy-L-proline price More Price(82)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	96310	Z-Hyp-OH ≥99.0% (T)	13504-85-3	25g	$151	2026-04-30	Buy
Sigma-Aldrich	96310	Z-Hyp-OH ≥99.0% (T)	13504-85-3	5g	$79	2023-06-20	Buy
TCI Chemical	C2506	trans-N-Carbobenzoxy-4-hydroxy-L-proline >98.0%(HPLC)(T)	13504-85-3	5g	$23	2026-04-30	Buy
TCI Chemical	C2506	trans-N-Carbobenzoxy-4-hydroxy-L-proline >98.0%(HPLC)(T)	13504-85-3	25g	$76	2026-04-30	Buy
Usbiological	269329	Cbz-L-hydroxyproline Asreported	13504-85-3	5g	$369	2026-06-03	Buy

Product number	Packaging	Price	Buy
96310	25g	$151	Buy
96310	5g	$79	Buy
C2506	5g	$23	Buy
C2506	25g	$76	Buy
269329	5g	$369	Buy

N-Cbz-Hydroxy-L-proline Chemical Properties, Uses, Production

Chemical Properties

Viscous Oil

Uses

A competitive inhibitor of porcine kidney prolidase.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

501-53-1

51-35-4

13504-85-3

GENERAL METHOD: To a solution of L-hydroxyproline (78.7 g, 600 mmol) and sodium bicarbonate (126 g, 1.5 mol) in water (900 mL), a solution of benzyl chloroformate (89.6 mL, 630 mmol) in dioxane (90 mL) was slowly added. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction (monitored by thin-layer chromatography), the reaction mixture was cooled to 0 °C in an ice bath and acidified to pH 2 with 12 M hydrochloric acid (about 75 mL was required). Subsequently, the aqueous phase was extracted with ethyl acetate (3 × 500 mL), the organic phases were combined and washed with saturated brine (3 × 200 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a colorless viscous oil. The yield was quantitative, and the product could be directly used in the next reaction without further purification.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 16, p. 1845 - 1847
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 47, p. 9073 - 9077
[3] Patent: EP1193270, 2002, A2. Location in patent: Page 14, 35-36, 105
[4] Tetrahedron Letters, 2016, vol. 57, # 44, p. 4882 - 4884
[5] Chemical and Pharmaceutical Bulletin, 2018, vol. 66, # 5, p. 575 - 580

N-Cbz-Hydroxy-L-proline synthesis

Synthesis of N-Cbz-Hydroxy-L-proline from Benzyl chloroformate and cis-4-Hydroxy-D-proline

N-Cbz-Hydroxy-L-proline Preparation Products And Raw materials

Raw materials

Benzyl chloroformate L-Hydroxyproline cis-4-Hydroxy-D-proline 1,4-Dioxane Sodium bicarbonate

Water

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Preparation Products

2-PyrrolidineMethanol, 4-hydroxy-, hydrochloride (1:1), (2S,4R)- N-BOC-cis-4-fluoro-L-proline (2S,4R)-1-((benzyloxy)carbonyl)-4-methoxypyrrolidine-2-carboxylic acid Z-trans-4-hydroxy-L-prolinol

N-Cbz-Hydroxy-L-proline Suppliers

Global Suppliers ( 352)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66

Supplier	Advantage
Shanghai Hobor Chemical Co., Ltd	60
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Ark Pharm, Inc.	56
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66

View Latest Price from N-Cbz-Hydroxy-L-proline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	N-Cbz-Hydroxy-L-proline 13504-85-3	$10.00	1KG	99%	5tons	Hebei Chuanghai Biotechnology Co., Ltd
2024-04-28	Z-Hyp-OH 13504-85-3	$5.00	1kg	99.92%	50000tons	Ouhuang Engineering Materials (Hubei) Co., Ltd
2022-01-26	Z-Hyp-oh 13504-85-3		1KG	98.3%	100 tons	Honest Joy Holdings Limited

N-Cbz-Hydroxy-L-proline
13504-85-3
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

Z-Hyp-OH
13504-85-3
$5.00
99.92%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Z-Hyp-oh
13504-85-3
$0.00
98.3%
Honest Joy Holdings Limited

N-Cbz-Hydroxy-L-proline Spectrum

N-Cbz-Hydroxy-L-proline(13504-85-3)¹HNMR

13504-85-3 (N-Cbz-Hydroxy-L-proline) Related Search:

Z-Hyp(tBu)-OMe L-Proline Trimethoprim D-Proline Nequinate

Cbz-N-methyl-L-phenylalanine cis-4-Hydroxy-D-proline Chlorophosphonazo III Carbonyl sulfide L-Proline-(4-3H(n))

Z-Hyp-OMe Z-Ile-Leu-OH Z-trans-4-hydroxy-L-prolinol N-Carbobenzoxy-L-isoleucine dicyclohexylammonium salt N-alpha-Cbz-L-lysine

N-Benzyloxycarbonyl-L-asparagine Z-Arg(NO2)-OH Z-D-Gln-OH

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(2S,4R)-N-Cbz-trans-4-hydroxy-L-proline Z-L-HYP-OH Z-L-4-HYDROXYPROLINE Z-L-4-TRANS-HYDROXYPROLINE TRANS-N-ALPHA-BENZYLOXYCARBONYL-L-HYDROXYPROLINE BENZYLOXYCARBONYL-L-4-HYDROXYPROLINE CBZ-L-HYDROXYPROLINE CBZ-L-HYP-OH N-Carbobenzyloxy-4-hydroxy-L-proline (trans) N-Z-4-hydroxy-L-proline (trans) 1-benzyl hydrogen (2S-trans)-4-hydroxypyrrolidine-1,2-dicarboxylate Z-trans-4-hydroxy-L-proline N-Cbz-cis-4-hydroxy-D-proline (2R,4R)-N-CBZ-4-HYDROXY-D-PROLINE Cbz-L-4- Hydroxyproline N-Benzyloxycarbonyl-4-hydroxy-L-proline N-Benzyloxycarbonyl-L-Hydroproline N-CARBOBENZYLOXY-TRANS-4-HYDROXY-L-PROLINE N-CBZ-CIS-4-HYDROXY-L-PROLINE CBZ-TRANS-4-HYDROXY-L-PROLINE Z-L-HYDROXYPROLINE extrapure N-carbobenzyloxy-hydroxy-L-proline N-Cbz-Hydroxy-L-proline, Z-L-4-Hydroxyproline (2S)-1-(Benzyloxycarbonyl)-4β-hydroxypyrrolidine-2α-carboxylic acid (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid hydrogen 1-(phenylmethyl) ester (4R)-1-(Benzyloxycarbonyl)-4-hydroxy-L-proline (4R)-N-(Benzyloxycarbonyl)-4-hydroxy-L-proline 1-(Benzyloxycarbonyl)-trans-4-hydroxy-L-proline N-(Benzyloxycarbonyl)-trans-4-hydroxy-L-proline (2R)-2-hydroxy-1-phenylmethoxycarbonyl-2-pyrrolidinecarboxylic acid N-ALPHA-CARBOBENZOXY-L-HYDROXYPROLINE N-ALPHA-CARBOBENZOXY-O-BENZYL-TRANS-4-HYDROXY-L-PROLINE N-ALPHA-CBZ-L-4-TRANS-HYDROXYPROLINE N-ALPHA-BENZYLOXYCARBONYL-TRANS-L-HYDROXYPROLINE N-ALPHA-CARBOBENZOXY-(2S,4R)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID N-CARBOBENZOXY-L-HYDROXYPROLINE N-CBZ-HYDROXY-L-PROLINE Z-4-HYDROXY-L-PROLINE Z-HYP(BZL)-OH Z-HYDROXYPROLINE Z-L-HYDROXYPROLINE N-carbobenzyloxy-4-hydroxy-l-proline 1-(benzyloxycarbonyl)-4-hydroxy-proline 4-hydroxy-1-(phenylmethoxycarbonyl)pyrrolidine-2-carboxylic acid (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, N-CBZ protected trans-4-Hydroxy-L-proline, N-CBZ protected 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(phenylMethyl) ester, (2S,4R)- trans-N-Carbobenzoxy-4-hydroxy-L-proline trans-N-Cbz-4-hydroxy-L-proline Z-Hyp-OH (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic Acid 1-Benzyl Ester N-CBZ-4-hydroxy-L-proline Z-Hyp-OH >=99.0% (T) Z-L-4-trans-hydroxyproline≥ 98% (HPLC) Z-Hyp-OH (Non-Animal Origiated Hyp) N-Carbobenzoxy-4-hydroxy-L-proline trans-N-Cbz-4-hydroxy-L-proline, 98% trans-N-Carbobenzoxy-4-hydroxy-L-proline > -4-hydroxy-L