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N-BOC-cis-4-fluoro-L-proline

N-BOC-cis-4-fluoro-L-proline Structure
N-BOC-cis-4-fluoro-L-proline structure
CAS No.
203866-13-1
Chemical Name:
N-BOC-cis-4-fluoro-L-proline
Synonyms
N-Boc-cis-4-F-L-Pro-OH;(2S<;Boc-4-F-L-Pro-OH;Boc-cis-Pro(4-F)-OH;Boc-cis-4-F-L-Pro-OH;BOC-CIS-4-FLUORO-PRO-OH;Boc-cis-L-4-Fluoroproline;BOC-CIS-4-FLUORO-L-PROLINE;N-Boc-cis-4-Fluoro-L-Proline;(2S,4S)-N-Boc-4-fluoroproline
CBNumber:
CB3490251
Molecular Formula:
C10H16FNO4
Molecular Weight:
233.24
MDL Number:
MFCD04973957
MOL File:
203866-13-1.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:20:56
Product description Number Pack Size Price
N-Boc-cis-4-fluoro-L-proline 97% 687324 500mg $154
(2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid >97.0%(GC)(T) B3178 1g $116
(2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid >97.0%(GC)(T) B3178 200mg $34
Boc-cis-4-fluoro-L-proline Asreported 265602 250mg $347
Boc-cis-4-fluoro-L-proline Asreported 265602 500mg $475
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N-BOC-cis-4-fluoro-L-proline Properties

Melting point 157-161.°C
Boiling point 346.0±42.0 °C(Predicted)
Density 1.24±0.1 g/cm3(Predicted)
refractive index -57 ° (C=1, MeOH)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form powder to crystal
pka 3.53±0.40(Predicted)
color White to Almost white
optical activity [α]22/D 71.0±5°, c = 1 in chloroform
InChI InChI=1S/C10H16FNO4/c1-10(2,3)16-9(15)12-5-6(11)4-7(12)8(13)14/h6-7H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m0/s1
InChIKey YGWZXQOYEBWUTH-BQBZGAKWSA-N
SMILES N1(C(OC(C)(C)C)=O)C[C@@H](F)C[C@H]1C(O)=O
CAS DataBase Reference 203866-13-1(CAS DataBase Reference)
UNSPSC Code 12352005
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
HazardClass  IRRITANT
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

N-BOC-cis-4-fluoro-L-proline price More Price(73)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 687324 N-Boc-cis-4-fluoro-L-proline 97% 203866-13-1 500mg $154 2023-06-20 Buy
TCI Chemical B3178 (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid >97.0%(GC)(T) 203866-13-1 1g $116 2026-04-30 Buy
TCI Chemical B3178 (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid >97.0%(GC)(T) 203866-13-1 200mg $34 2026-04-30 Buy
Usbiological 265602 Boc-cis-4-fluoro-L-proline Asreported 203866-13-1 250mg $347 2026-06-03 Buy
Usbiological 265602 Boc-cis-4-fluoro-L-proline Asreported 203866-13-1 500mg $475 2026-06-03 Buy
Product number Packaging Price Buy
687324 500mg $154 Buy
B3178 1g $116 Buy
B3178 200mg $34 Buy
265602 250mg $347 Buy
265602 500mg $475 Buy

N-BOC-cis-4-fluoro-L-proline Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

N-Boc-cis-4-fluoro-L-proline can be used as a substrate in the preparation of:

  • α4β2 Receptor ligands bearing pyrrolidine nucleus.
  • β-Amino pyrrolidine-2-carbonitrile derivatives as possible dipeptidyl peptidase IV (DPP4) inhibitors.

Synthesis

N-Boc-cis-4-Fluoro-L-proline methyl ester

203866-16-4

N-BOC-cis-4-fluoro-L-proline

203866-13-1

General procedure for the synthesis of (2S,4S)-4-fluoro-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid from N-tert-butoxycarbonyl-cis-4-fluoro-L-proline methyl ester: To a solution of N-tert-butoxycarbonyl-cis-4-fluoro-L-proline methyl ester (5.83 g, 23.58 mmol) in tetrahydrofuran (THF, 30 mL) was added, at 0 °C, lithium hydroxide (LiOH, 1.98 g) in aqueous solution (30 mL). The reaction mixture was stirred at room temperature for 2 h. The pH was subsequently adjusted to 5 with dilute hydrochloric acid (1 M). After evaporating THF under reduced pressure, the pH of the aqueous layer was adjusted to 2 with dilute hydrochloric acid (1 M) and extracted with ethyl acetate (EtOAc, 80 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to afford (2S,4S)-4-fluoro-1-tert-butoxycarbonylpyrrolidine-2-carboxylic acid as a white solid (5.3 g, 96% yield). The structure of the compound was confirmed by the following spectral data: mass spectrum (ESI, positive ion mode) m/z: 234.24 [M + H]+; NMR hydrogen spectrum (400 MHz, CDCl3) δ (ppm): 8.76 (broad single peak, 1H), 5.28-5.12 (multiple peaks, 1H), 4.56-4.44 (multiple peaks, 1H), 3.86- 3.58 (multiple peaks, 2H), 2.77-2.01 (multiple peaks, 2H), 1.48-1.44 (double peaks, 9H, J = 16 Hz).

References

[1] Patent: WO2014/19344, 2014, A1. Location in patent: Paragraph 00435
[2] Patent: WO2014/82380, 2014, A1. Location in patent: Paragraph 00403; 00405
[3] Patent: WO2014/82379, 2014, A1. Location in patent: Page/Page column 144; 145
[4] Patent: WO2014/131315, 2014, A1. Location in patent: Page/Page column 144
[5] Patent: US2015/79028, 2015, A1. Location in patent: Paragraph 1061; 1066; 1067; 1068; 1069

N-BOC-cis-4-fluoro-L-proline synthesis

203866-16-4
203866-13-1
Synthesis of N-BOC-cis-4-fluoro-L-proline from N-Boc-cis-4-Fluoro-L-proline methyl ester

N-BOC-cis-4-fluoro-L-proline Preparation Products And Raw materials

Raw materials

1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-(phenylmethyl) ester, (2S,4S)- N-Boc-trans-4-Hydroxy-L-proline methyl ester BOC-HYP-OBZL N-Boc-cis-4-Fluoro-L-proline methyl ester （2s，4s）-1-benzyl-2-methy-4-fluoropyrrolidine-1，2-dicarbo
N-Cbz-Hydroxy-L-proline trans-4-Hydroxy-L-proline methyl ester hydrochloride Boc-Hyp-OH Z-HYP-OME Di-tert-butyl dicarbonate

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Preparation Products

(S)-1-(tert-Butoxycarbonyl)-2,3-dihydro-1H-pyrrole-2-carboxylic acid 1-Boc-(2S,4S)-2-cyano-4-fluoropyrrolidine

N-BOC-cis-4-fluoro-L-proline Suppliers

Global( 220)Suppliers
Supplier Tel Email Country ProdList Advantage
PRISUN PHARMATECH CO.,LTD
+86-021-54326183-8001 +86-18917565227 prisun@prisunpharma.com China 214 58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		+86-15225627621 +86-13213167925 jiuyitime@fdachem.com China 16505 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14034 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
Biochempartner 		0086-13720134139 candy@biochempartner.com CHINA 963 58
HaBo Hong Kong Co., Limited. 		+86-25-18512596065 info@habotech.com CHINA 931 58
Accela ChemBio Inc. 		+1-858-6993322 +86-18019713315 info@accelachem.com United States 21189 58
BTC Nantong Pharmaceuticals Technology Co.,Ltd 		+86-0513-81283365 Info@btcpharm.com China 248 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63645 58
Supplier Advantage
PRISUN PHARMATECH CO.,LTD
58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
career henan chemical co 		58
Biochempartner 		58
HaBo Hong Kong Co., Limited. 		58
Accela ChemBio Inc. 		58
BTC Nantong Pharmaceuticals Technology Co.,Ltd 		58
Alchem Pharmtech,Inc. 		58

View Lastest Price from N-BOC-cis-4-fluoro-L-proline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N-BOC-cis-4-fluoro-L-proline pictures 2026-07-02 N-BOC-cis-4-fluoro-L-proline
203866-13-1
 $2.20-8.80 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
N-BOC-cis-4-fluoro-L-proline pictures 2024-02-26 N-BOC-cis-4-fluoro-L-proline
203866-13-1
 1kg 98% BTC Nantong Pharmaceuticals Technology Co.,Ltd
N-BOC-cis-4-fluoro-L-proline pictures 2021-07-13 N-BOC-cis-4-fluoro-L-proline
203866-13-1
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

N-BOC-cis-4-fluoro-L-proline Spectrum

N-BOC-cis-4-fluoro-L-proline(203866-13-1)1HNMRN-BOC-cis-4-fluoro-L-proline(203866-13-1)FT-IR

203866-13-1(N-BOC-cis-4-fluoro-L-proline)Related Search:

BOC-L-Proline N-Methyl-2-pyrrolidone Pyrrolidine cis-4-Hydroxy-L-proline tert-Butyl carbazate
Povidone iodine L-PROLINE-(4-3H(N)) D-Proline tert-Butanol Polyvinylpyrrolidone
Ascoric Acid N-Boc-(2R,3R,4S)-dolaproine TERT-BUTYL N-(2-HYDROXYETHYL)CARBAMATE N-Boc-4-piperidinemethanol N-Boc-endo-3-aminotropane
N-Boc-exo-3-aminotropane N-Boc-pyrroline N-Boc-3-piperidineacetic acid

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(2S,4S)-N-Boc-4-fluoropyrrolidine-2-carboxy lic acid Boc-cis-L-4-Fluoroproline 4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid (2S,4S)-N-Boc-cis-4-Fluoro-L-proline (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid, N-BOC protected cis-4-Fluoro-L-proline, N-BOC protected (2S,4S)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid N-(tert-Butoxycarbonyl)-cis-4-fluoro-L-proline N-Boc-cis-4-fluoro-L-proline Boc-(2S,4S)-4-fluoro-pyrrolidine-2-carboxylic acid, Boc-flp-OH Boc-4-F-L-Pro-OH cis-4-Fluoro-L-proline, N-BOC protected, (4S)-1-(tert-Butoxycarbonyl)-4-fluoro-L-proline (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid Boc-cis-4-F-L-Pro-OH 1,2-Pyrrolidinedicarboxylicacid, 4-fluoro-, 1-(1,1-dimethylethyl) ester, (2S,4S)- (Tert-Butoxy)Carbonyl cis-L-4-FluoroPro Methyl 2-(aminomethyl)pyridine-4-carboxylate, HCl (2S,4S)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid N-TERT-BUTOXYCARBONYL-CIS-4-FLUORO-L-PROLINE N-T-BOC-CIS-4-FLUORO-L-PROLINE BOC-CIS-4-FLUORO-L-PROLINE BOC-CIS-4-FLUORO-PRO-OH N-Boc-cis-4-Fluoro-L-Proline (2S,4S)-BOC-4-FLUORO-PYRROLIDINE-2-CARBOXYLIC ACID (2S,4S)-4-FLUORO-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (2S,4S)-4-FLUORO-1-TERT-BUTOXYCARBONYL-PYRROLIDINE-2-CARBOXYLIC ACID (2S,4S)-4-Fluoro-N-Boc-Pyrrolidine-2-carboxylic acid N-BOC-(4S,2S)-4-FLUORO-2-PYRROLIDINECARBOXYLICACID (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid (2S,4S)-1-Boc-4-fluoro-2-pyrrolidinecarboxylic Acid (2S,4S)-N-BOC -4-FLUORO-L-PROLINE CIS-1-(TERT-BUTOXYCARBONYL)-4-FLUOROPYRROLIDINE-2-CARBOXYLIC ACID (2S,4S)-1-(tert-Butoxycarbonyl)-4-fluoro-2-pyrrolidinecarboxylic Acid > (2S,4S)-4-fluoro-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylicaci N-BOC-cis-4-fluoro-L-proline USP/EP/BP Boc-cis-Pro(4-F)-OH (2S,4S)-N-Boc-4-fluoroproline N-tert-Boc-cis-4-fluoro-L-proline (2S,4S)-1-Boc-4-fluoropyrrolidine-2-carboxylic Acid (2S< N-Boc-cis-4-fluoro-L-proline N-Boc-cis-4-F-L-Pro-OH 203866-13-1 208366-13-1 C10H16FNO4 Carboxylic Acids (Chiral) Chiral Building Blocks Synthetic Organic Chemistry Chiral Building Blocks Heterocyclic Building Blocks Pyrrolidines Nitrogen cyclic compounds 11