2-Methoxycinnamic acid
- CAS No.
- 6099-03-2
- Chemical Name:
- 2-Methoxycinnamic acid
- Synonyms
- TRANS-2-METHOXYCINNAMIC ACID;1533716;AI3-11206;AKOS BBB/196;AURORA 11318;AKOS BBS-00007900;RARECHEM BK HC T255;2-Methoxyciamic acid;2-Methoxycinmic acid;O-METHOXYCINNAMIC ACID
- CBNumber:
- CB5152937
- Molecular Formula:
- C10H10O3
- Molecular Weight:
- 178.18
- MDL Number:
- MFCD00064238
- MOL File:
- 6099-03-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 182-186 °C |
|---|---|
| Boiling point | 250.41°C (rough estimate) |
| Density | 1.1479 (rough estimate) |
| refractive index | 1.5088 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | powder |
| pka | pK1:4.462 (25°C) |
| color | White |
| BRN | 2209714 |
| InChI | InChI=1S/C10H10O3/c1-13-9-5-3-2-4-8(9)6-7-10(11)12/h2-7H,1H3,(H,11,12) |
| InChIKey | FEGVSPGUHMGGBO-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C=CC1=CC=CC=C1OC |
| LogP | 2.418 (est) |
| CAS DataBase Reference | 6099-03-2(CAS DataBase Reference) |
| FDA UNII | J77SK1Y4MY |
| NIST Chemistry Reference | 2-Propenoic acid, 3-(2-methoxyphenyl)-(6099-03-2) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29189900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
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| NFPA 704 |
|
2-Methoxycinnamic acid price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M13408 | 2-Methoxycinnamic acid, predominantly trans 98% | 6099-03-2 | 25g | $127 | 2023-06-20 | Buy |
| Sigma-Aldrich | 65400 | 2-Methoxycinnamic acid ≥97.0% | 6099-03-2 | 10g | $78.4 | 2023-06-20 | Buy |
| Biosynth | FM71289 | 2-Methoxycinnamic acid | 6099-03-2 | 0.1kg | $162.25 | 2026-06-04 | Buy |
| Biosynth | FM71289 | 2-Methoxycinnamic acid | 6099-03-2 | 0.25kg | $324.5 | 2026-06-04 | Buy |
| Biosynth | FM71289 | 2-Methoxycinnamic acid | 6099-03-2 | 0.5kg | $519.2 | 2026-06-04 | Buy |
2-Methoxycinnamic acid Chemical Properties,Uses,Production
Chemical Properties
light yellow crystalline powder
Uses
(E)-3-(2-Methoxyphenyl)acrylic Acid is a noncompetitive inhibitor of tyrosinase.
Definition
ChEBI: (E)-2-methoxycinnamic acid is a member of the class of cinnamic acids that is trans-cinnamic acid carrying a methoxy substituent at position 2 on the benzene ring. It has a role as a Brassica napus metabolite and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a member of cinnamic acids and a monomethoxybenzene. It is functionally related to a trans-cinnamic acid.
Synthesis
141-82-2
135-02-4
6099-03-2
To a 500 mL three-necked round-bottomed flask was added o-methoxybenzaldehyde (20 g, 146.90 mmol, 1.00 eq.), pyridine (250 mL), malonic acid (18.3 g, 175.86 mmol, 1.20 eq.) and piperidine (2.5 g, 29.36 mmol, 0.20 eq.). The reaction mixture was stirred at 85°C overnight. Upon completion of the reaction, most of the solvent was removed by distillation under reduced pressure, followed by adjusting the pH of the remaining solution with aqueous hydrochloric acid to 3.0. The precipitated solid was collected by filtration to afford 25.6 g (98% yield) of 2-methoxycinnamic acid as a white solid.
References
[1] Patent: WO2014/182950, 2014, A1. Location in patent: Paragraph 00322; 00323
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 336 - 343
[3] Journal of the Indian Chemical Society, 1988, vol. 65, # 3, p. 187 - 191
[4] Molecules, 2009, vol. 14, # 10, p. 4166 - 4179
[5] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 15, p. 4513 - 4519
2-Methoxycinnamic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zaoyang Cixiang Medical Technology Co., Ltd | 19871689299 | 1242417277@qq.com | China | 52 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| RYSS TECH LTD | 400-188-0725 +86 21 34310725 13611771617 | China | 1999 | 57 |
View Lastest Price from 2-Methoxycinnamic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 2-Methoxycinnamic acid
6099-03-2
|
$1.00 | 1KG | 99% | 50 tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2026-07-27 | 2-Methoxycinnamic acid
6099-03-2
|
$29.00 | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-05-28 | 2-Methoxycinnamic Acid
6099-03-2
|
$19.00 | 1KG | 99.% | 50 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 2-Methoxycinnamic acid
6099-03-2
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Methoxycinnamic acid
6099-03-2
- $29.00
- 99.68%
- TargetMol Chemicals Inc.
-
- 2-Methoxycinnamic Acid
6099-03-2
- $19.00
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
