(4-bromo-2-methylphenyl)methanol
- CAS No.
- 17100-58-2
- Chemical Name:
- (4-bromo-2-methylphenyl)methanol
- Synonyms
- 4-Bromo-2-methylbenzyl alcohol;4-bromo-2-methylBenzenemethanol;(4-bromo-2-methylphenyl)methanol;Benzenemethanol, 4-bromo-2-methyl-;(4-Bromo-2-methylphenyl)methanol, 5-Bromo-2-(hydroxymethyl)toluene
- CBNumber:
- CB51553995
- Molecular Formula:
- C8H9BrO
- Molecular Weight:
- 201.06
- MDL Number:
- MFCD11847398
- MOL File:
- 17100-58-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 76.0 to 80.0 °C |
|---|---|
| Boiling point | 287.8±25.0 °C(Predicted) |
| Density | 1.481±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 14.17±0.10(Predicted) |
| color | White to Orange to Green |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| HS Code | 2906290090 |
(4-bromo-2-methylphenyl)methanol price More Price(75)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B5231 | 4-Bromo-2-methylbenzyl Alcohol >98.0%(GC) | 17100-58-2 | 1g | $36 | 2026-04-30 | Buy |
| TCI Chemical | B5231 | 4-Bromo-2-methylbenzyl Alcohol >98.0%(GC) | 17100-58-2 | 5g | $109 | 2026-04-30 | Buy |
| Usbiological | 266491 | 4-Bromo-2-methylbenzyl alcohol Asreported | 17100-58-2 | 500mg | $382 | 2026-06-03 | Buy |
| Usbiological | 266491 | 4-Bromo-2-methylbenzyl alcohol Asreported | 17100-58-2 | 1g | $688 | 2026-06-03 | Buy |
| Usbiological | 266491 | 4-Bromo-2-methylbenzyl alcohol Asreported | 17100-58-2 | 2g | $980 | 2026-06-03 | Buy |
(4-bromo-2-methylphenyl)methanol Chemical Properties, Uses, Production
Application
(4-Bromo-2-methylphenyl)methanol is an intermediate in the synthesis of antitumor drugs, and also a molecular probe for the preparation of photosensitive materials, alcohol oxidases, and labeled proteins and DNA.
Synthesis
68837-59-2
17100-58-2
Step a: 2-methyl-4-bromobenzoic acid (11.1 g, 51.6 mmol) was dissolved in anhydrous THF (11.2 mL). The solution was cooled to 0-5 °C and 1 M of BH3-THF solution (103 mL) was added slowly. The reaction mixture was stirred at room temperature for 3 hours. Upon completion of the reaction, the reaction was quenched by careful addition of cold water (20 mL) and subsequently washed with saturated NaHCO3 solution (120 mL). The aqueous phase was extracted with ether (3 x 300 mL) and the combined organic phases were washed with brine (200 mL), dried with anhydrous MgSO4 and concentrated in vacuum. The resulting crude product was purified by fast column chromatography with a gradient ratio of hexane/EtOAc (from 95:5 to 70:30) as eluent to afford the target product (4-bromo-2-methylphenyl)methanol (10.4 g, 100% yield) as a colorless transparent oil.1H NMR (300 MHz, CDCl3): δ 7.36-7.30 (2H, m), δ 7.25-7.21 (1H, m), 4.65 (2H, s), 2.32 (3H, s).
References
[1] Journal of Medicinal Chemistry, 1984, vol. 27, # 11, p. 1516 - 1531
[2] Patent: WO2008/18827, 2008, A1. Location in patent: Page/Page column 61
[3] Patent: WO2014/78608, 2014, A1. Location in patent: Paragraph 00280
[4] Patent: WO2015/171757, 2015, A1. Location in patent: Page/Page column 55
[5] Patent: US2014/100179, 2014, A1. Location in patent: Paragraph 0020; 0022
(4-bromo-2-methylphenyl)methanol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
View Latest Price from (4-bromo-2-methylphenyl)methanol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | (4-bromo-2-methylphenyl)methanol
17100-58-2
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- (4-bromo-2-methylphenyl)methanol
17100-58-2
- $9.80
- ≥99%
- Career Henan Chemical Co
