4-Bromo-2-methylbenzoic acid
- CAS No.
- 68837-59-2
- Chemical Name:
- 4-Bromo-2-methylbenzoic acid
- Synonyms
- 4-Bromo-2-methyL;Fluralaner-038;RARECHEM AL BO 0455;4-Bromo-2-methylbenz;4-Bromo-o-toluic acid;Fluralaner Impurity 58;4-Bromo-2-methylbenzoic;5-Bromo-2-carboxytoluene;4-Bromo-2-methylbenzoicaci;4-Brom-2-methylbenzoic acid
- CBNumber:
- CB0188342
- Molecular Formula:
- C8H7BrO2
- Molecular Weight:
- 215.04
- MDL Number:
- MFCD00040905
- MOL File:
- 68837-59-2.mol
- MSDS File:
- SDS
| Melting point | 180-184 °C |
|---|---|
| Boiling point | 310.1±30.0 °C(Predicted) |
| Density | 1.599±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 3.63±0.25(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| Water Solubility | Insoluble in water. |
| BRN | 2249816 |
| InChI | InChI=1S/C8H7BrO2/c1-5-4-6(9)2-3-7(5)8(10)11/h2-4H,1H3,(H,10,11) |
| InChIKey | RVCJOGNLYVNRDN-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(Br)C=C1C |
| CAS DataBase Reference | 68837-59-2(CAS DataBase Reference) |
| FDA UNII | W689VK4N9Y |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 29163990 | |||||||||
| NFPA 704 |
|
4-Bromo-2-methylbenzoic acid price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 665126 | 4-Bromo-2-methylbenzoic acid 97% | 68837-59-2 | 5g | $84 | 2023-06-20 | Buy |
| Sigma-Aldrich | 665126 | 4-Bromo-2-methylbenzoic acid 97% | 68837-59-2 | 25g | $268 | 2023-06-20 | Buy |
| TCI Chemical | B3337 | 4-Bromo-2-methylbenzoic Acid >98.0%(GC)(T) | 68837-59-2 | 5g | $129 | 2025-07-31 | Buy |
| TCI Chemical | B3337 | 4-Bromo-2-methylbenzoic Acid >98.0%(GC)(T) | 68837-59-2 | 25g | $643 | 2025-07-31 | Buy |
| Sigma-Aldrich | 665126 | 4-Bromo-2-methylbenzoic acid 97% | 68837-59-2 | 100g | $605 | 2023-06-20 | Buy |
4-Bromo-2-methylbenzoic acid Chemical Properties,Uses,Production
Chemical Properties
White to brown crystal powde
Uses
A building block which is used in preparation of anthranilic acids possessing antibacterial activity. 4-bromo-2-methylbenzoic acid could be used to synthesis 4-chloro-3'-(2-cyclopentyl-1-oxoisoindolin-5-yl)biphenyl-3-carboxylic acid through Suzuki couplings[1].
Synthesis
67832-11-5
68837-59-2
General procedure for the synthesis of 2-methyl-4-bromobenzoic acid from 4-bromo-2-methylbenzonitrile: 4-bromo-2-methylbenzonitrile (1 mmol) was suspended in water (49 mL) and potassium hydroxide (50 mmol) was added. The reaction mixture was stirred overnight under reflux conditions. Upon completion of the reaction, it was cooled to room temperature and the basic aqueous solution was washed with ethyl acetate (3 x 15 mL) to remove unreacted material. Subsequently, the aqueous phase was acidified to pH < 2 with 6 M hydrochloric acid and the acidified aqueous phase was extracted with ethyl acetate (3 x 15 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the white solid product 2-methyl-4-bromobenzoic acid. Yield: 60%. Thin Layer Chromatography (TLC) analysis (unfolding agent: dichloromethane/methanol = 9:1): Rf = 0.46. melting point: 182 °C. 1H-NMR (300 MHz, CD3OD) δ (ppm): 7.80 (d, J = 8.4 Hz, 1H, H-6), 7.48 (s, 1H, H-3), 7.42 (d, J = 8.4 Hz, 1H, H- 5), 2.56 (s, H- 5), 2.56 (s, H- 5), 2.56 (s, H- 5). 5), 2.56 (s, 3H, CH3).
References
[1] Shyama Sidique. “Orally Active Metabotropic Glutamate Subtype 2 Receptor Positive Allosteric Modulators: Structure–Activity Relationships and Assessment in a Rat Model of Nicotine Dependence.” Journal of Medicinal Chemistry 55 22 (2012): 9434–9445.
4-Bromo-2-methylbenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Nordica Biopharma CO.,LTD | +86-18136148818 +86-18567353071 | 3537297702@qq.com | China | 299 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8617732866630 | abby@chuanghaibio.com | China | 8773 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +8613288715578 | sales@hbmojin.com | China | 12371 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5251 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29734 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 12930 | 58 |
| Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 988 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29855 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
View Lastest Price from 4-Bromo-2-methylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-15 | 4-Bromo-2-methylbenzoic acid
68837-59-2
|
US $0.00 / Kg/Bag | 1KG | 98%min | 500KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-08-08 | 4-Bromo-2-methylbenzoic acid
68837-59-2
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-06-24 | 4-Bromo-2-methylbenzoic acid
68837-59-2
|
US $10.00 / kg | 1kg | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 4-Bromo-2-methylbenzoic acid
68837-59-2
- US $0.00 / Kg/Bag
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 4-Bromo-2-methylbenzoic acid
68837-59-2
- US $0.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 4-Bromo-2-methylbenzoic acid
68837-59-2
- US $10.00 / kg
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
