3-N-Butylphthalide
- CAS No.
- 6066-49-5
- Chemical Name:
- 3-N-Butylphthalide
- Synonyms
- butylphthalide;3-Butylphthalide;3-n-Butylphathlide;3-Butylisobenzofuran-1(3H)-one;FEMA 3334;Butylphathlide;3-butyl-1(3H)-Isobenzofuranone;n-Butylphthalide;BUTYLPHTHALIDE, 3-n-(P);CL234
- CBNumber:
- CB5174179
- Molecular Formula:
- C12H14O2
- Molecular Weight:
- 190.24
- MDL Number:
- MFCD01704513
- MOL File:
- 6066-49-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3-N-Butylphthalide ≥98% (HPLC) | SMB00312 | 25 mg | $281 |
| Butylphthalide min. 98.0 % | B6520 | 1G | $69 |
| Butylphthalide min. 98.0 % | B6520 | 5G | $239 |
| DL-3-n-Butylphthalide ≥98% | 30284 | 500mg | $75 |
| DL-3-n-Butylphthalide ≥98% | 30284 | 1g | $134 |
| More product size | |||
| Boiling point | 265.75°C (rough estimate) |
|---|---|
| Density | 1.0527 (rough estimate) |
| refractive index | 1.5197 (estimate) |
| FEMA | 3334 | 3-N-BUTYLPHTHALIDE |
| FLAVIS Number | 10.025 | 3-Butylphthalide |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Chloroform (Slightly), Methanol (Slightly); Almost insoluble in water, soluble in alcohol and oils. |
| form | Oil |
| color | Colourless to Yellow |
| Odor | at 10.00 % in dipropylene glycol. herbal phenolic celery |
| Odor Type | herbal |
| JECFA Number | 1169 |
| Stability | Hygroscopic |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| Cosmetics Ingredients Functions | PERFUMING |
| InChI | 1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h4-7,11H,2-3,8H2,1H3 |
| InChIKey | HJXMNVQARNZTEE-UHFFFAOYSA-N |
| SMILES | O=C1C2=CC=CC=C2C(CCCC)O1 |
| LogP | 2.80 |
| Substances Added to Food (formerly EAFUS) | 3-N-BUTYLPHTHALIDE |
| EWG's Food Scores | 1 |
| FDA UNII | 822Q956KGM |
| NIST Chemistry Reference | 3-Butylphthalide(6066-49-5) |
| EPA Substance Registry System | 1(3H)-Isobenzofuranone, 3-butyl- (6066-49-5) |
| UNSPSC Code | 12352205 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| target organs | Respiratory system |
| WGK Germany | WGK 3 |
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
3-N-Butylphthalide price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00312 | 3-N-Butylphthalide ≥98% (HPLC) | 6066-49-5 | 25 mg | $281 | 2026-04-30 | Buy |
| TCI Chemical | B6520 | Butylphthalide min. 98.0 % | 6066-49-5 | 1G | $69 | 2026-04-30 | Buy |
| TCI Chemical | B6520 | Butylphthalide min. 98.0 % | 6066-49-5 | 5G | $239 | 2026-04-30 | Buy |
| Cayman Chemical | 30284 | DL-3-n-Butylphthalide ≥98% | 6066-49-5 | 500mg | $75 | 2026-04-30 | Buy |
| Cayman Chemical | 30284 | DL-3-n-Butylphthalide ≥98% | 6066-49-5 | 1g | $134 | 2026-04-30 | Buy |
3-N-Butylphthalide Chemical Properties,Uses,Production
Chemical Properties
3-N-Butylphthalide has a warm, spicy herbaceous odor.
Occurrence
Reported found in Levisticum officinale (lovage) and L. acutilobum; also in celery oil.
Uses
3-Butylphthalide is a cardiovascular drug used for the treatment of cerebral ischemic stroke. This interesting Lactone finds use in the composing of meat flavors, spice blends, etc.
Definition
ChEBI: Butylphthalide is a member of benzofurans.
Preparation
From celery oil; from phthalide via bromination and subsequent reaction of the resulting phthalidic acid with n-butyl magnesium bromide.
Aroma threshold values
Detection: 5 ppb
Biological Activity
3-N-Butylphthalide (NBP), a family of compounds initially isolated from the seeds of Apium graveolens Linn., has shown significant neuroprotective effects.[1]
References
[1] A Review of Recent Advances in Neuroprotective Potential of 3-N-Butylphthalide and Its Derivatives. DOI:10.1155/2016/5012341
3-N-Butylphthalide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Dowell Chemical Co.,Ltd | +86-17692413312 | sell@dowechem.com | China | 89 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +86-15988602810 | sales@anbuchem.com | China | 3107 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7240 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3618 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Jinan Chenghui-Shuangda Chemical Co.,Ltd | +86-531-58897082 | ericqiao@jnchsd.com | CHINA | 158 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
Related articles
- 3-n-Butylphthalide: a promising therapeutic drug for inflammatory disease
- 3-n-Butylphthalide (NBP), a pure component extracted from Apium graveolens Linn, was approved by the China Food and Drug Admin....
- Dec 10，2024
View Lastest Price from 3-N-Butylphthalide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-13 | 3-n-Butylphthalide
6066-49-5
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-07-27 | Butylphthalide
6066-49-5
|
$29.00 | 98.34% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | 3-N-BUTYLPHTHALIDE
6066-49-5
|
$1.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- 3-n-Butylphthalide
6066-49-5
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Butylphthalide
6066-49-5
- $29.00
- 98.34%
- TargetMol Chemicals Inc.
-
- 3-N-BUTYLPHTHALIDE
6066-49-5
- $1.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
