2-(Trifluoromethyl)benzoyl chloride
- CAS No.
- 312-94-7
- Chemical Name:
- 2-(Trifluoromethyl)benzoyl chloride
- Synonyms
- alpha,alpha,alpha-Trifluoro-o-toluoyl chloride;à;OTF-BOC;TIMTEC-BB SBB006689;TrifluoroMethyl)benzoyl chlori;α,α,α-trifluoro-o-toluoyl chloride;à,à,à-trifluoro-o-toluoyl chloride;2-(TrifluoroMehtyl)benzoylcholride;2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE;O-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
- CBNumber:
- CB5193552
- Molecular Formula:
- C8H4ClF3O
- Molecular Weight:
- 208.57
- MDL Number:
- MFCD00000667
- MOL File:
- 312-94-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | -22 °C |
|---|---|
| Boiling point | 84-85 °C16 mm Hg(lit.) |
| Density | 1.416 g/mL at 25 °C(lit.) |
| vapor pressure | 60.66Pa at 25℃ |
| refractive index |
n |
| Flash point | 204 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Liquid |
| Specific Gravity | 1.416 |
| color | Clear pink or yellow |
| Water Solubility | decomposes |
| Sensitive | Lachrymatory |
| BRN | 881040 |
| InChI | 1S/C8H4ClF3O/c9-7(13)5-3-1-2-4-6(5)8(10,11)12/h1-4H |
| InChIKey | MXIUWSYTQJLIKE-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1ccccc1C(Cl)=O |
| LogP | 2.086 |
| CAS DataBase Reference | 312-94-7(CAS DataBase Reference) |
| FDA UNII | D01D0B64EQ |
| NIST Chemistry Reference | 2-(Trifluoromethyl)benzoyl chloride(312-94-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H290-H318-H314 | |||||||||
| Precautionary statements | P309-P280-P305+P351+P338-P310-P234-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501 | |||||||||
| PPE | Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-37-29 | |||||||||
| Safety Statements | 26-36/37/39-45-8 | |||||||||
| RIDADR | UN 3265 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 19-21 | |||||||||
| Hazard Note | Corrosive/Lachrymatory | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 8A - Combustible corrosive hazardous materials | |||||||||
| Hazard Classifications | Skin Corr. 1B | |||||||||
| Toxicity | skn-rbt 500 mg/24H MOD FCTXAV 13,681,75 | |||||||||
| REACH Registrations | Inactive | |||||||||
| Limited Quantities | 1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
2-(Trifluoromethyl)benzoyl chloride price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 249483 | 2-(Trifluoromethyl)benzoyl chloride 99% | 312-94-7 | 25g | $271 | 2023-01-07 | Buy |
| TCI Chemical | T1280 | 2-(Trifluoromethyl)benzoyl Chloride >98.0%(GC)(T) | 312-94-7 | 25g | $36 | 2026-04-30 | Buy |
| TRC | TRC-T791135-25G | 2-(Trifluoromethyl)benzoyl Chloride | 312-94-7 | 25g | $220 | 2026-06-03 | Buy |
| TRC | TRC-T791135-10G | 2-(Trifluoromethyl)benzoyl Chloride | 312-94-7 | 10g | $167 | 2026-06-03 | Buy |
| TRC | TRC-T791135-100G | 2-(Trifluoromethyl)benzoyl Chloride | 312-94-7 | 100g | $661 | 2026-06-03 | Buy |
2-(Trifluoromethyl)benzoyl chloride Chemical Properties, Uses, Production
Chemical Properties
colorlesstolightyellowliqui
Uses
2-(Trifluoromethyl)benzoyl chloride may be used in chemical synthesis.
Safety Profile
A skin irritant. When heated todecomposition it emits acrid smoke and irritating fumes.
Synthesis
433-97-6
312-94-7
Step 2: Synthesis of 2-(trifluoromethyl)benzoyl chloride Oxalyl chloride (36.72 mg, 0.29 mmol) was slowly added to a stirred solution of 2-(trifluoromethyl)benzoic acid (50 mg, 0.26 mmol) in dichloromethane (3 mL) followed by dropwise addition of N,N-dimethylformamide (DMF, 4 drops). The resulting reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and 2-(trifluoromethyl)benzoyl chloride (95.6 mg, 100% yield) was obtained quantitatively, which was used directly in the subsequent reaction without purification.
References
[1] Patent: US2010/160323, 2010, A1. Location in patent: Page/Page column 28
[2] Journal of the American Chemical Society, 1947, vol. 69, p. 2352
[3] Bulletin de la Societe Chimique de France, 1962, p. 587 - 593
[4] Journal of Medicinal Chemistry, 1982, vol. 25, # 2, p. 145 - 152
[5] Journal of Medicinal Chemistry, 1999, vol. 42, # 6, p. 981 - 991
2-(Trifluoromethyl)benzoyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Xinyang Ruihe Chemical Technology Co., Ltd. | 13720181483 13720181483 | 366443693@QQ.COM | China | 994 | 58 |
| Zouping Innovation Pharmaceutical Co., Ltd. | 13561560789 | xinxiaoxiao2008@126.com | China | 686 | 58 |
| Jinan Junhe Pharmaceutical Co., Ltd | 13475558980 13475558980 | 644535754@qq.com | China | 345 | 58 |
| Qingdao Baiyi Chemical Co., Ltd | 13953303907 | 2338367690@qq.com | China | 103 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Latest Price from 2-(Trifluoromethyl)benzoyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | 2-(Trifluoromethyl)benzoyl chloride
312-94-7
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | 2-(Trifluoromethyl)benzoyl chloride
312-94-7
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-06-30 | 2-(Trifluoromethyl)benzoyl chloride
312-94-7
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-(Trifluoromethyl)benzoyl chloride
312-94-7
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 2-(Trifluoromethyl)benzoyl chloride
312-94-7
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-(Trifluoromethyl)benzoyl chloride
312-94-7
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
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