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8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE structure

CAS No.: 149771-44-8

Chemical Name:: 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE

Synonyms: (1R,5S)-tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate;8-t-butoxycarbonyl-3,8-diazabicyclo[3.2.1]octane;tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylatelate;1,1-Dimethylethyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate;3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 1,1-diMethylethyl ester;EOS-62177;8-BOC-3,8-DIAZA;8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE;1H-Imidazole-4-carboxaldehyde,4-methyl-;149771-44-8

CBNumber:: CB5214428

Molecular Formula:: C11H20N2O2

Molecular Weight:: 212.29

MDL Number:: MFCD04115137

MOL File:: 149771-44-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:47:31

Product description	Number	Pack Size	Price
tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate min. 98.0 %	D6459	1G	$39
tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate min. 98.0 %	D6459	5G	$158
8-Boc-3,8-diaza-bicyclo[3.2.1]octane Asreported	263597	25mg	$355
8-Boc-3,8-diaza-bicyclo[3.2.1]octane Asreported	263597	50mg	$489
8-Boc-3,8-diaza-bicyclo[3.2.1]octane Asreported	263597	100mg	$672

Request For Quotation

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Properties

Boiling point	295.4±15.0 °C(Predicted)
Density	1.076±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	9.53±0.20(Predicted)
form	solid
color	White to off-white
InChI	InChI=1S/C11H20N2O2/c1-11(2,3)15-10(14)13-8-4-5-9(13)7-12-6-8/h8-9,12H,4-7H2,1-3H3
InChIKey	HNINFCBLGHCFOJ-UHFFFAOYSA-N
SMILES	C12N(C(OC(C)(C)C)=O)C(CC1)CNC2

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H319
Precautionary statements	P305+P351+P338
HS Code	2933599590

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE price More Price(89)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D6459	tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate min. 98.0 %	149771-44-8	1G	$39	2026-04-30	Buy
TCI Chemical	D6459	tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate min. 98.0 %	149771-44-8	5G	$158	2026-04-30	Buy
Usbiological	263597	8-Boc-3,8-diaza-bicyclo[3.2.1]octane Asreported	149771-44-8	25mg	$355	2026-06-03	Buy
Usbiological	263597	8-Boc-3,8-diaza-bicyclo[3.2.1]octane Asreported	149771-44-8	50mg	$489	2026-06-03	Buy
Usbiological	263597	8-Boc-3,8-diaza-bicyclo[3.2.1]octane Asreported	149771-44-8	100mg	$672	2026-06-03	Buy

Product number	Packaging	Price	Buy
D6459	1G	$39	Buy
D6459	5G	$158	Buy
263597	25mg	$355	Buy
263597	50mg	$489	Buy
263597	100mg	$672	Buy

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Chemical Properties,Uses,Production

Uses

tert-Butyl 3,8-Diazabicyclo[3.2.1]octane-8-carboxylate is used in preparation of isoquinolinone derivatives and pharmaceutical compounds thereof for prevention or treatment of poly(ADP-ribose)polymerase-1 (PARP-1)-associated diseases.

Synthesis

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE

149771-43-7

149771-44-8

The hydrogenation reaction of tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate (13.0 g, 43.0 mmol) was carried out in ethanol (100 mL, 99%) in the presence of palladium carbon (4.0 g, 5%) catalyst. Upon completion of the reaction, the mixture was filtered through diatomaceous earth and the filtrate was dried and the solvent evaporated to afford the white powdery product tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate. The yield was 8.4 g (92% yield) and the melting point was 103.4-106°C. The product was obtained as follows.

References

[1] Journal of Medicinal Chemistry, 1998, vol. 41, # 5, p. 674 - 681
[2] Patent: US2002/128271, 2002, A1
[3] Patent: EP1213289, 2002, A1. Location in patent: Page 13
[4] Patent: WO2006/106090, 2006, A1. Location in patent: Page/Page column 16
[5] Tetrahedron Letters, 2002, vol. 43, # 5, p. 899 - 902

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Preparation Products And Raw materials

Raw materials

3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 3-(2,2,2-trifluoroacetyl)-, 1,1-diMethylethyl ester TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE Ethanol Hydrogen

Preparation Products

TERT-BUTYL 3-BENZYL-3,8-DIAZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE 4-BOC-1-(5-BROMO-2-PYRIDYL)PIPERAZINE

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Suppliers

Global( 261)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Labnetwork lnc.	+86-27-50766799 +86-18062016861	contact@labnetwork.com	China	19981	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	14032	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10399	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8491	58
Accela ChemBio Inc.	+1-858-6993322 +86-18019713315	info@accelachem.com	United States	21189	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
career henan chemical co	+86-0371-86658258	factory@coreychem.com	China	29780	58
Jinan Liheng Biotechnology Co., Ltd.	15865262812	info@lihengpharm.com	CHINA	937	58
ENBRIDGE PHARMTECH CO., LTD.	+8613812269233	tinayang@enbridgepharm.com	China	308	58

Supplier	Advantage
Labnetwork lnc.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Jinan Liheng Biotechnology Co., Ltd.	58
ENBRIDGE PHARMTECH CO., LTD.	58

Related Qustion

Ask a question

Q:What is the synthesis and use of 8-Boc-3,8-diaza-bicyclo[3.2.1]octane?Zora - Dec 29，2025

A:8-Boc-3,8-diaza-bicyclo[3.2.1]octane is used as a versatile synthetic intermediate in the realm of organic chemistry, particularly in the synthesis of complex molecules and potential catalysts. It is synthesized by hydrogenation in ethanol in the presence of palladium on carbon catalyst, using 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester as the raw material.

View Lastest Price from 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE 149771-44-8	1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-04-04	8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE 149771-44-8	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
2022-02-09	8-Boc-3,8-diaza-bicyclo[3.2.1]octane 149771-44-8	1KG	98.7%	100 tons	Honest Joy Holdings Limited

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE
149771-44-8
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE
149771-44-8
98%
Henan Aochuang Chemical Co.,Ltd.

8-Boc-3,8-diaza-bicyclo[3.2.1]octane
149771-44-8
$0.00
98.7%
Honest Joy Holdings Limited

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE Spectrum

8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE(149771-44-8)¹HNMR

149771-44-8(8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE)Related Search:

1-Oxa-7-azaspiro[4.5]decane-7-carboxylic acid, 3-oxo-, 1,1-diMethylethyl ester TERT-BUTYL 5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,6-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate hydrochloride tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

tert-butyl 6-hydroxy-3-azabicyclo[3.1.0]hexane-3-carboxylate 3-AMINO-1-[(1,1-DIMETHYLETHOXY)CARBONYL]-3-PIPERIDINEACETIC ACID METHYL ESTER TERT-BUTYL N-ALLYLCARBAMATE 1-Boc-3-methyl-3-hydroxyp... 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

N-BOC-3-METHYLENE-PIPERIDINE tert-butyl 3,3a,4,5-tetrahydro-5-oxocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl carbazate tert-butyl 3,8-diazabicyclo[3.2.1]octane-3-carboxylate tert-butyl 2-oxo-6-azaspiro[3.5]nonane-6-carboxylate

(R)-1-N-Boc-2-methylpiperazine (R)-2-(Aminomethyl)-1-N-Boc-pyyrolidine (S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine

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8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE 3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 8-BOC protected 97+% 1,1-Dimethylethyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate EOS-62177 8-Boc-3,8-diaza-bicyclo[3.2.1]octane hydrochloride 3,8-Diazabicyclo[3.2.1]octan-8-carboxylic acid tert-butyl ester 8-(tert-Butoxycarbonyl)-3,8-diazabicyclo[3.2.1]octane tert-butyl (1S,5R)-3,8-diazabicyclo[3.2.1]octane-8-carboxylate 3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester 8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE ISO 9001：2015 REACH 1H-Imidazole-4-carboxaldehyde,4-methyl- ert-Butyl3,8-diazabicyclo[3.2.1]octane-8-carboxylate 3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 1,1-dimethylethyl ester (9CI, ACI) 149771-44-8 8-BOC-3,8-DIAZA 3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 8-BOC protected 8-Boc-3,8-diaza-bicyclo[3.2.1]octane - [D14360] tert-Butyl 3,8-diazabicyclo[3.2.1]octan-8-carboxylate 8-BOC-8-BOC-3,8-DIAZA-BICYCLO[3.2.1]OCTANE 8-t-butoxycarbonyl-3,8-diazabicyclo[3.2.1]octane (1R,5S)-tert-butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate 3,8-Diazabicyclo[3.2.1]octane-8-carboxylic acid, 1,1-diMethylethyl ester tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylatelate 149771-44-8 pharmaceutical 1