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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester structure

CAS No.: 206989-61-9

Chemical Name:: 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester

Synonyms: tert-Butyl 4-acetylpiperidine-1-carboxylate;N-Boc-4-acetylpiperidine;1-Boc-4-acetyL;N-Boc-4-Acetypiperidine;Zanubrutinib Impurity 6;Zanubrutinib impurity-22;1-BOC-4-ACETYL-PIPERIDINE;-N-Boc-4-Acetylpiperidine;1-N-Boc-4-Acetylpiperidine;1-BOC-ESTER4-ACETYL-PIPERIDINE

CBNumber:: CB7704363

Molecular Formula:: C12H21NO3

Molecular Weight:: 227.3

MDL Number:: MFCD08437655

MOL File:: 206989-61-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:46:54

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4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Properties

Boiling point	312.4±35.0 °C(Predicted)
Density	1.052±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-2.23±0.40(Predicted)
form	solid
Appearance	Colorless to off-white Liquid
InChI	InChI=1S/C12H21NO3/c1-9(14)10-5-7-13(8-6-10)11(15)16-12(2,3)4/h10H,5-8H2,1-4H3
InChIKey	HNVBBNZWMSTMAZ-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCC(C(C)=O)CC1
UNSPSC Code	12352200
NACRES	NA.21

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P301+P310
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 2811 6.1 / PGIII
HazardClass	IRRITANT
HS Code	2933399990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Oral

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SYX00409	tert-Butyl 4-acetylpiperidine-1-carboxylate	206989-61-9	1g	$32.7	2026-04-30	Buy
Usbiological	232744	4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester ≥97% (GC) ≥97%(GC)	206989-61-9	250mg	$192	2026-06-03	Buy
Usbiological	232744	4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester ≥97% (GC) ≥97%(GC)	206989-61-9	1g	$233	2026-06-03	Buy
Usbiological	232744	4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester ≥97% (GC) ≥97%(GC)	206989-61-9	5g	$482	2026-06-03	Buy
Usbiological	232744	4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester ≥97% (GC) ≥97%(GC)	206989-61-9	25g	$1310	2026-06-03	Buy

Product number	Packaging	Price	Buy
SYX00409	1g	$32.7	Buy
232744	250mg	$192	Buy
232744	1g	$233	Buy
232744	5g	$482	Buy
232744	25g	$1310	Buy

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Uses,Production

Appearance

Light yellow oil

Uses

tert-Butyl 4-Acetylpiperidine-1-carboxylate is a useful research chemical.

Synthesis

Tert-butyl-4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate (2.29 g, 8.32 mmol) was dissolved in 30 ml of tetrahydrofuran (THF), and the resulting solution was cooled to -78 °C. To the solution, methylmagnesium bromide (3.0 M) (7.73 ml, 10.82 mmol) was slowly added, and the solution was stirred at 0 °C for 1 hr. After the reaction was completed with a 2 N hydrochloric acid aqueous solution, 6 N sodium hydroxide solution was added to adjust the pH to 10. Then the solution was extracted with dichloromethane. The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated. The resulting residue was isolated and purified by silica gel column chromatography (dichloromethane/methanol = 10/1) to give 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester (6.36 g, 94.0 percent).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 4, p. 935 - 939
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 5, p. 1299 - 1305
[3] Patent: EP3255042, 2017, A2. Location in patent: Paragraph 0209; 0212
[4] Patent: WO2008/17461, 2008, A1. Location in patent: Page/Page column 62
[5] Patent: WO2008/42925, 2008, A1. Location in patent: Page/Page column 96

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester synthesis

Synthesis of 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester from 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

4-(2-ETHOXYCARBONYL-ACETYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine Methylmagnesium Bromide

Preparation Products

2-bromo-1-(1-Boc-piperidin-4-yl)ethanone TERT-BUTYL 4-(1-AMINOETHYL)PIPERIDINE-1-CARBOXYLATE tert-butyl 4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)piperidine-1-carboxylate

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Suppliers

Global( 228)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan Argalbio Technology Co,.Ltd	028-028-60651388 13980413900	slyu@hengkangtech.com	China	575	58
Shanghai Hobor Chemical Co., Ltd	13918007836	sales@hoborchem.com	China	423	60
Shanghai Kahn Pharmaceutical Co., Ltd.	021-34979681; 17701870669	41513101@qq.com	China	1785	55
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Tetranov Biopharm	13526569071	sales@leadmedpharm.com	China	7882	64
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59

Supplier	Advantage
Sichuan Argalbio Technology Co,.Ltd	58
Shanghai Hobor Chemical Co., Ltd	60
Shanghai Kahn Pharmaceutical Co., Ltd.	55
Anhui Dexinjia Biopharm Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Capot Chemical Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Tetranov Biopharm	64
Adamas Reagent, Ltd.	59

View Lastest Price from 4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	Tert-Butyl 4-Acetylpiperidine-1-Carboxylate 206989-61-9	$1.60-6.60	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-06-30	4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester 206989-61-9		1kg	99%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2019-07-06	N-Boc-4-piperidineacetate 206989-61-9	$1.00	1KG	98%	500kg	Career Henan Chemical Co

Tert-Butyl 4-Acetylpiperidine-1-Carboxylate
206989-61-9
$1.60-6.60
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester
206989-61-9
$0.00
99%
Shaanxi Dideu New Materials Co. Ltd

N-Boc-4-piperidineacetate
206989-61-9
$1.00
98%
Career Henan Chemical Co

4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester Spectrum

4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(206989-61-9)¹HNMR 4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(206989-61-9)FT-IR

206989-61-9(4-Acetyl-piperidine-1-carboxylic acid tert-butyl ester)Related Search:

1-Piperidinecarboxylic acid, 4-[3-(dimethylamino)-1-oxo-2-propen-1-yl]-, 1,1-dim Propanedinitrile, 2-[hydroxy(4-phenoxyphenyl)Methylene]- Propanedinitrile, 2-[Methoxy(4-phenoxyphenyl)Methylene]- tert-butyl 4-(3-cyano-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate 5-aMino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile

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tert-butyl 4-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate tert-Butyl 3,8-diazabicyclo[3.2.1]octane-8-carboxylate hydrochloride 2-OXO-2,5-DIHYDRO-PYRROLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

1of4

4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-4-Acetylpiperidine 1-tert-Butoxycarbonyl-4-acetylpiperidine 1-Piperidinecarboxylic acid, 4-acetyl-, 1,1-dimethylethyl ester 1-BOC-4-ACETYL-PIPERIDINE N-Boc-4-Acetypiperidine 1-BOC-ESTER4-ACETYL-PIPERIDINE 4-acetyl-piperidine-1-carboxylic acid Mono t-butyl ester 4-acetyl-1-piperidinecarboxylic acid tert-butyl ester tert-butyl 4-ethanoylpiperidine-1-carboxylate 4-acetyl-1-(t-butoxycarbonyl)piperidine 1-Boc-4-acetyL Zanubrutinib Related Compound 4 Zanubrutinib Impurity 6 -N-Boc-4-Acetylpiperidine 7-(1-benzoylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide Zanubrutinib benzoyl amide impurity Zanubrutinib impurity-22 tert-Butyl 4-acetylpiperidine-1-carboxylate 1-(tert-Butoxycarbonyl)piperidin-4-yl methyl ketone N-Boc-4-acetylpiperidine tert-Butyl 4-acetylpiperidine-1-carboxylate 206989-61-9 206979-61-9 C12H20NO4