tert-Butyl N-(3-aminopropyl)-N-methylcarbamate
- CAS No.
- 150349-36-3
- Chemical Name:
- tert-Butyl N-(3-aminopropyl)-N-methylcarbamate
- Synonyms
- N-(3-Aminopropyl)-N-methylcarbamic acid tert-butyl ester citrate;BUTTPARK 90\06-20;BOC-N-ME-1,3-DIAMINOPROPANE;Boc-N-Me-1,3-diaminopropane·HCl;N-Boc-N-Methyl-1,3-diaMinopropane;3-(N-Boc-N-methylamino)propylamine;N1-BOC-N1-METHYL-1,3-PROPANEDIAMINE;1-N-BOC-1-N-METHYL-1,3-DIAMINOPROPANE;N-Boc-N-methyl-1,3-diaminopropane,95%;1-N-BOC-1-N-Methyl-1,3-DIAMINOPROPANE-HCl
- CBNumber:
- CB5242948
- Molecular Formula:
- C9H20N2O2
- Molecular Weight:
- 188.27
- MDL Number:
- MFCD01631189
- MOL File:
- 150349-36-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 254.6±19.0 °C(Predicted) |
|---|---|
| Density | 0.982±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| pka | 10.06±0.10(Predicted) |
| form | Liquid |
| color | Pale yellow |
| Water Solubility | Slightly soluble in water. |
| CAS DataBase Reference | 150349-36-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HS Code | 2924190090 | |||||||||
| NFPA 704 |
|
tert-Butyl N-(3-aminopropyl)-N-methylcarbamate price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 467117 | tert-Butyl 3-Aminopropyl(methyl) Carbamate | 150349-36-3 | 250mg | $305 | 2026-06-03 | Buy |
| Usbiological | 467117 | tert-Butyl 3-Aminopropyl(methyl) Carbamate | 150349-36-3 | 500mg | $389 | 2026-06-03 | Buy |
| Usbiological | 265587 | Boc-N-Me-1,3-diaminopropane·HCl Asreported | 150349-36-3 | 500mg | $333 | 2026-06-03 | Buy |
| Usbiological | 265587 | Boc-N-Me-1,3-diaminopropane·HCl Asreported | 150349-36-3 | 1g | $470 | 2026-06-03 | Buy |
| Usbiological | 265587 | Boc-N-Me-1,3-diaminopropane·HCl Asreported | 150349-36-3 | 2g | $679 | 2026-06-03 | Buy |
tert-Butyl N-(3-aminopropyl)-N-methylcarbamate Chemical Properties, Uses, Production
Uses
It is an important raw material and intermediate used in organic synthesis, agrochemicals and dyestuff.
Synthesis
24424-99-5
6291-84-5
150349-36-3
GENERAL STEPS: Preparation Example 1 Synthesis of tert-butyl-N-(3-aminopropyl)-N-methylcarbamate (2). N-methyl-1,3-propanediamine (1) (3.26 g, 37.03 mmol) was dissolved in methanol (100 ml), and a 35% hydrochloric acid solution was slowly added at 0 °C, followed by stirring. The reaction solution was stirred at room temperature for 30 min, then cooled to -10 °C and di-tert-butyl dicarbonate (10.51 g, 48.14 mmol) was slowly added. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and alkalized with 10% aqueous sodium hydroxide solution. The alkalized solution was extracted with dichloromethane and the organic phase was dried with anhydrous magnesium sulfate. The dried organic phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent ratio: dichloromethane: methanol: ammonia = 100:9:1, v/v/v) to give tert-butyl N-(3-aminopropyl)-N-methylcarbamate (2). Yield: 3.03 g (43%).1H NMR (400 MHz, CDCl3) δ 3.29 (2H, br, -CH2-NH2), 2.83 (3H, s, -N-CH3), 2.69 (2H, t, J = 6Hz, -N-CH2-CH2-), 1.64 (2H, m, -CH2-CH2-CH2-). 1.46 (9H, s, (CH3)3C-O-CO-), 1.38 (2H, s, -CH2-CH2-NH2).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 3, p. 1073 - 1079
[2] Patent: US2017/81291, 2017, A1. Location in patent: Paragraph 0023; 0046; 0047; 0048
[3] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 6, p. 1565 - 1570
tert-Butyl N-(3-aminopropyl)-N-methylcarbamate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Boc Chemical Co.,Ltd | 021-34975603-808 18721111801 | sales@bocpharma.com | China | 991 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
View Latest Price from tert-Butyl N-(3-aminopropyl)-N-methylcarbamate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-01-04 | 3-(N-Boc-N-methylamino)propylamine
150349-36-3
|
1g | 98%min | 100kgs/month | Shanghai Rlavie Technology Co ltd | ||
 |
2020-01-14 | tert-Butyl N-(3-aminopropyl)-N-methylcarbamate
150349-36-3
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3-(N-Boc-N-methylamino)propylamine
150349-36-3
- 98%min
- Shanghai Rlavie Technology Co ltd
-
- tert-Butyl N-(3-aminopropyl)-N-methylcarbamate
150349-36-3
- $7.00
- 99%
- Career Henan Chemical Co
