6-Chloronicotinoyl chloride
- CAS No.
- 58757-38-3
- Chemical Name:
- 6-Chloronicotinoyl chloride
- Synonyms
- SKL1253;BUTTPARK 96\50-26;6- chloridesMokechloride;6-Chloronicotinoyl Chlorid;6-CHLORONICOTINYL CHLORIDE;6-Chloronicotinoyl chloride;6-Chloronicotinoylchloride,98%;6-Chloronicotinoyl Chloride >6-CHLOROPYRIDINE-3-CARBONYL CHLORIDE;2-CHLOROPYRIDINE-5-CARBONYL CHLORIDE
- CBNumber:
- CB5331396
- Molecular Formula:
- C6H3Cl2NO
- Molecular Weight:
- 176
- MDL Number:
- MFCD00051775
- MOL File:
- 58757-38-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 48-51 °C(lit.) |
|---|---|
| Boiling point | 84-85°C 3mm |
| Density | 1.454±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | soluble in Toluene |
| pka | -2.65±0.10(Predicted) |
| form | Solid |
| color | White to off-white |
| Sensitive | Moisture Sensitive |
| BRN | 115927 |
| CAS DataBase Reference | 58757-38-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H318-H290-H314 | |||||||||
| Precautionary statements | P234-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P390-P405-P406-P501-P260h-P301+P330+P331-P303+P361+P353-P305+P351+P338-P501a | |||||||||
| Hazard Codes | Xi,C | |||||||||
| Risk Statements | 36/37/38-34 | |||||||||
| Safety Statements | 26-36-45-36/37/39 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 2933399990 | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
6-Chloronicotinoyl chloride price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C1726 | 6-Chloronicotinoyl Chloride >98.0%(T) | 58757-38-3 | 5g | $42 | 2026-04-30 | Buy |
| TCI Chemical | C1726 | 6-Chloronicotinoyl Chloride >98.0%(T) | 58757-38-3 | 25g | $122 | 2026-04-30 | Buy |
| Usbiological | 267405 | 6-Chloronicotinoyl chloride Asreported | 58757-38-3 | 5g | $322 | 2026-06-03 | Buy |
| Usbiological | 267405 | 6-Chloronicotinoyl chloride Asreported | 58757-38-3 | 10g | $452 | 2026-06-03 | Buy |
| Usbiological | 267405 | 6-Chloronicotinoyl chloride Asreported | 58757-38-3 | 25g | $612 | 2026-06-03 | Buy |
6-Chloronicotinoyl chloride Chemical Properties,Uses,Production
Uses
6-Chloronicotinoyl chloride serves as an acylating agent for synthesizing N-(6-chloronicotinoyl)-β-aminobutyric acid via Schotten–Baumann reaction with β-aminobutyric acid and NaOH at –7 to –5°C, yielding the product in over 60% yield[1]. The reagent acylates steroidal substrates, including 3β,5α,6β-trihydroxysteroids, 3β,5-dihydroxy-6-ketosteroids, and 20-hydroxyecdysone (in pyridine at room temperature), to produce new esters containing 6-chloropyridine groups[2][3].
Synthesis
6-Chloronicotinoyl chloride is prepared by reacting 6-methoxynicotinic acid with thionyl chloride in refluxing DMF, followed by vacuum distillation to afford the product in high yield[2].
References
[1]Kovganko, N. V., Sokolov, S. N., & Chernov, Y. G. (2011). Synthesis of α-chloropyridine derivatives of γ-aminobutyric acid. Chemistry of Natural Compounds, 47(5), 781–782. https://doi.org/10.1007/s10600-011-0057-4
[2]Kovganko, N. V., Chernov, Y. G., Sokolov, S. N., Kashkan, Z. N., & Survilo, V. L. (2009). Synthesis of 6-chloronicotinates of steroidal 3β,5α,6β-triols and 3β,5-dihydroxy-6-ketones. Chemistry of Natural Compounds, 45(2), 200–204. https://doi.org/10.1007/s10600-009-9265-6
[3]Bobaev, I. D., Kovganko, N. V., Chernov, Y. G., Utaeva, Z. R., Sokolov, S. N., Kashkan, Z. N., & Ramazanov, N. S. (2009). Synthesis of 20-hydroxyecdysone 6-chloronicotinates. Chemistry of Natural Compounds, 45(3), 385–388. https://doi.org/10.1007/s10600-009-9338-6
6-Chloronicotinoyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
View Lastest Price from 6-Chloronicotinoyl chloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 6-CHLORONICOTINOYL CHLORIDE
58757-38-3
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2019-07-06 | 6-CHLORONICOTINOYL CHLORIDE
58757-38-3
|
$2.00 | 1KG | 99% | Career Henan Chemical Co |
-
- 6-CHLORONICOTINOYL CHLORIDE
58757-38-3
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 6-CHLORONICOTINOYL CHLORIDE
58757-38-3
- $2.00
- 99%
- Career Henan Chemical Co
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