Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
- CAS No.
- 118853-60-4
- Chemical Name:
- Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
- Synonyms
- Methyl 6-aminopyrazine-2-carboxylate;6-Aminopyrazine-2-carboxyL;methyl 6-aminopyrazine-2-car;Methyl 6-amino-2-pyrazinecarboxylate;6-Aminopyrazinecarboxylic acid methyl ester;2-Pyrazinecarboxylic acid, 6-amino-, methyl ester;Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
- CBNumber:
- CB91064150
- Molecular Formula:
- C6H7N3O2
- Molecular Weight:
- 153.14
- MDL Number:
- MFCD10697802
- MOL File:
- 118853-60-4.mol
- MSDS File:
- SDS
| Boiling point | 341.2±37.0 °C(Predicted) |
|---|---|
| Density | 1.319 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 1.22±0.10(Predicted) |
| Appearance | Yellow to brown Solid |
| InChI | InChI=1S/C6H7N3O2/c1-11-6(10)4-2-8-3-5(7)9-4/h2-3H,1H3,(H2,7,9) |
| InChIKey | MFQOPTGQOOILCR-UHFFFAOYSA-N |
| SMILES | C1(C(OC)=O)=NC(N)=CN=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2922390090 |
Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR302497 | Methyl 6-aminopyrazine-2-carboxylate 95% | 118853-60-4 | 100mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | OR302497 | Methyl 6-aminopyrazine-2-carboxylate 95% | 118853-60-4 | 250mg | $30 | 2026-06-04 | Buy |
| Apolloscientific | OR302497 | Methyl 6-aminopyrazine-2-carboxylate 95% | 118853-60-4 | 1g | $70 | 2026-06-04 | Buy |
| Apolloscientific | OR302497 | Methyl 6-aminopyrazine-2-carboxylate 95% | 118853-60-4 | 5g | $293 | 2026-06-04 | Buy |
| Matrix Scientific | 303612 | Methyl 6-aminopyrazine-2-carboxylate | 118853-60-4 | 1.00g | $84 | 2026-05-19 | Buy |
Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) Chemical Properties, Uses, Production
Uses
Methyl 6-Aminopyrazine-2-carboxylate is used in preparation of bicyclic compounds for use in antibacterial applications.
Synthesis
23611-75-8
118853-60-4
General procedure for the synthesis of methyl 6-amino-2-pyrazinecarboxylate from methyl 6-chloropyrazine-2-carboxylate: methyl 6-chloropyrazine-2-carboxylate (2 g, 0.0115 mol) was dissolved in 80 mL of dimethylsulfoxide (DMSO). To this solution, sodium azide (3 g, 0.0463 mol) and triphenylphosphine (4.6 g, 0.01738 mol) were sequentially added, followed by refluxing the reaction mixture at 120 °C for 4 hours. Upon completion of the reaction, 20 mL of 1 N hydrochloric acid solution was added to the mixture and the reaction was continued at 120 °C for 2 hours. At the end of the reaction, the mixture was cooled to room temperature and neutralized with aqueous sodium bicarbonate solution, followed by extraction of the target product with ethyl acetate. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated, and the residue was washed with n-pentane to give 1.4 g of methyl 6-amino-2-pyrazinecarboxylate as a yellow solid in 82.4% yield. The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 8.28-8.27 (m, 1H), 8.07 (s, 1H), 6.90 (s, 2H), 3.84 (s, 3H). Molecular weight of the molecular formula C6H7N3O2 is 153.14; mass spectrum (ESI) m/z: [M + H]+: 154.05.
References
[1] European Journal of Pharmaceutical Sciences, 2018, vol. 124, p. 165 - 181
Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Kohn & Shawn Pharmatech Co.,Ltd | 0943-8293106 | sales@kyxpharma.com | China | 297 | 55 |
| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
| Cantotech Chemicals, Ltd. | 86-0755-86635001 | cantotech@126.com | China | 4554 | 55 |
| JIANGYIN CANAL PHARMTECH CO.,LIMITED. | +86-18921203887 | sales@canalpharm.net | China | 288 | 58 |
View Latest Price from Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-07-06 | Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
118853-60-4
|
$1.00 | 1KG | 98% | 150KG | Career Henan Chemical Co |
-
- Pyrazinecarboxylic acid, 6-amino-, methyl ester (9CI)
118853-60-4
- $1.00
- 98%
- Career Henan Chemical Co
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