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4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE structure

CAS No.: 90035-34-0

Chemical Name:: 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE

Synonyms: AKOS BAR-0197;4-[4-(TRIFLUOROMETHYL)PHENYL]BENZALDEHYDE;4'-Trifluoromethyl-biphenyl-4-carbaldehyde;4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE;4'-Trifluoromethylbiphenyl-4-carboxaldehyde;4'-(Trifluoromethyl)-Biphenyl-4-Carboxaldehyde;4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBALDEHYDE;4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carbaldehyde;4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXALDEHYDE;[1,1'-Biphenyl]-4-carboxaldehyde,4'-(trifluoroMethyl)-

CBNumber:: CB5482973

Molecular Formula:: C14H9F3O

Molecular Weight:: 250.22

MDL Number:: MFCD01862519

MOL File:: 90035-34-0.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:50

Product description	Number	Pack Size	Price
4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxaldehyde >98.0%(GC)	T3755	1g	$52
4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxaldehyde >98.0%(GC)	T3755	5g	$181
4'-Trifluoromethylbiphenyl-4-carbaldehyde	291337	500mg	$333
4''-Trifluoromethyl-biphenyl-4-carbaldehyde	T797165	100mg	$75
4'-(Trifluoromethyl)[1,1'-biphenyl]-4-carbaldehyde >95%	042875	5g	$120
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4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE Properties

Melting point	70-72°C
Boiling point	319.7±42.0 °C(Predicted)
Density	1.251±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	powder to crystal
color	White to Light yellow
CAS DataBase Reference	90035-34-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2916399090

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T3755	4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxaldehyde >98.0%(GC)	90035-34-0	1g	$52	2025-07-31	Buy
TCI Chemical	T3755	4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-carboxaldehyde >98.0%(GC)	90035-34-0	5g	$181	2025-07-31	Buy
Usbiological	291337	4'-Trifluoromethylbiphenyl-4-carbaldehyde	90035-34-0	500mg	$333	2021-12-16	Buy
TRC	T797165	4''-Trifluoromethyl-biphenyl-4-carbaldehyde	90035-34-0	100mg	$75	2021-12-16	Buy
Matrix Scientific	042875	4'-(Trifluoromethyl)[1,1'-biphenyl]-4-carbaldehyde >95%	90035-34-0	5g	$120	2021-12-16	Buy

Product number	Packaging	Price	Buy
T3755	1g	$52	Buy
T3755	5g	$181	Buy
291337	500mg	$333	Buy
T797165	100mg	$75	Buy
042875	5g	$120	Buy

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE Chemical Properties,Uses,Production

Synthesis

128796-39-4

1122-91-4

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE

90035-34-0

Step A: To a round bottom flask was added 4-bromobenzaldehyde (69.6 g, 376 mmol), 4-(trifluoromethyl)phenylboronic acid (75.0 g, 395 mmol), and 1-propanol (appropriate amount), and the reaction mixture was stirred for 15 min at 70 °C until a clarified solution was obtained. Triphenylphosphine (888 mg, 3.38 mmol), palladium(II) acetate (256 mg, 1.13 mmol), 2M aqueous sodium carbonate (226 mL, 451 mmol), and water (138 mL) were sequentially added to the resulting solution. The reaction system was heated and refluxed for 1 hour, keeping the system open to air. Upon completion of the reaction, water (900 mL) was added and the reaction mixture was cooled to 7°C. Stirring was continued for 30 minutes until 4'-(trifluoromethyl)biphenyl-4-carbaldehyde was completely precipitated. The precipitate was collected by filtration and the solid was washed with cold water (~600 mL). The solid was dissolved in diethyl ether (500 mL), filtered through a pad of diatomaceous earth and silica, and the filter cake was washed with diethyl ether (2 x 500 mL). The filtrate was concentrated under reduced pressure to give 4'-(trifluoromethyl)biphenyl-4-carbaldehyde (90.0 g, 96% yield) as a pure white solid. The product was confirmed structurally by 1H NMR (400 MHz, CDCl3, δ): 7.75 (s, 4H), 7.76-7.79 (m, 2H), 7.96-8.04 (m, 2H), 10.10 (s, 1H). Mass spectrometry (MS) showed [M + 1] peak at 250.3.

References

[1] Patent: US2012/165343, 2012, A1. Location in patent: Page/Page column 15
[2] Applied Organometallic Chemistry, 2012, vol. 26, # 9, p. 478 - 482
[3] Patent: WO2005/118542, 2005, A1. Location in patent: Page/Page column 43; 55-56
[4] Green Chemistry, 2011, vol. 13, # 1, p. 169 - 177
[5] ChemMedChem, 2016, p. 2194 - 2204

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE Preparation Products And Raw materials

Raw materials

4-Trifluoromethylphenylboronic acid 4-Bromobenzotrifluoride 4-Formylphenylboronic acid 4-Bromobenzaldehyde 4-Formylphenylboronic acid pinacol cyclic ester

Water 1-Propanol Sodium carbonate

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Preparation Products

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE Suppliers

Global( 159)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29734	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13456	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29799	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Apeloa Pharmaceutical Co., Ltd.	+86-0571-87635730 +8615858229168	chem1022@hengdian-group.com	China	1478	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Jinan Carbotang Biotech Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Antai Fine Chemical Technology Co.,Limited	58
Apeloa Pharmaceutical Co., Ltd.	58

View Lastest Price from 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2022-12-02	4'-Trifluoromethyl-biphenyl-4-carbaldehyde 90035-34-0	US $200.00 / g	10g	99%	1000t/month	Hebei Best Biological Technology Co., Ltd
2022-05-23	4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE 90035-34-0	US $1.10 / g	1g	99.0% Min	100 Tons	Dideu Industries Group Limited
2021-07-09	4-PHENYL]BENZALDEHYDE;AKOS BAR-0197 90035-34-0		1KG	98%	500 Ton/Tons per Month	Hebei Xibaijie Biotechnology Co., Ltd.

4'-Trifluoromethyl-biphenyl-4-carbaldehyde
90035-34-0
US $200.00 / g
99%
Hebei Best Biological Technology Co., Ltd

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE
90035-34-0
US $1.10 / g
99.0% Min
Dideu Industries Group Limited

4-PHENYL]BENZALDEHYDE;AKOS BAR-0197
90035-34-0
98%
Hebei Xibaijie Biotechnology Co., Ltd.

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE Spectrum

4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE(90035-34-0)¹HNMR 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE(90035-34-0)¹⁹FNMR

90035-34-0(4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE)Related Search:

4'-TRIFLUOROMETHYLBIPHENYL-4-CARBOXYLIC ACID 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE 2'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE,2'-Trifluoromethyl-biphenyl-4-carbaldehyde 4-(TRIFLUOROMETHYL)-BIPHENYL 1-(4'-TRIFLUOROMETHYL-BIPHENYL-4-YL)-ETHANONE

4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBALDEHYDE 3'-TRIFLUOROMETHYL-BIPHENYL-2-CARBALDEHYDE 3',5'-DI-(TRIFLUOROMETHYL)-BIPHENYL-4-CARBALDEHYDE 2'-TRIFLUOROMETHYL-BIPHENYL-2-CARBALDEHYDE 4'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE,4'-Trifluoromethyl-biphenyl-3-carbaldehyde

2'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE,2'-Trifluoromethyl-biphenyl-3-carbaldehyde 3',5'-DI-(TRIFLUOROMETHYL)-BIPHENYL-3-CARBALDEHYDE 3'-Trifluoromethyl-biphenyl-4-carbaldehyde 4'-FLUORO-3'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE 4'-FLUORO-3'-TRIFLUOROMETHYL-BIPHENYL-3-CARBALDEHYDE

AKOS BAR-2205 RARECHEM AL BI 1218 AKOS BAR-2067

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4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBALDEHYDE 4'-(TRIFLUOROMETHYL)[1,1'-BIPHENYL]-4-CARBOXALDEHYDE 4-[4-(TRIFLUOROMETHYL)PHENYL]BENZALDEHYDE AKOS BAR-0197 [1,1'-Biphenyl]-4-carboxaldehyde,4'-(trifluoroMethyl)- 4'-(Trifluoromethyl)-Biphenyl-4-Carboxaldehyde 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE ISO 9001：2015 REACH 4'-(trifluoromethyl)-[1,1'-biphenyl]-4-carbaldehyde 4'-Trifluoromethyl-biphenyl-4-carbaldehyde 4'-Trifluoromethylbiphenyl-4-carboxaldehyde 4′-(Trifluoromethyl)-[1,1′-biphenyl]-4-carboxaldehyde, CAS 90035-34-0 4'-TRIFLUOROMETHYL-BIPHENYL-4-CARBALDEHYDE 90035-34-0 ALDEHYDE CHIRAL CHEMICALS Phenyls & Phenyl-Het pharmacetical Aldehydes Phenyls & Phenyl-Het Biphenyl & Diphenyl ether