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SCRIPTAID

SCRIPTAID structure

CAS No.: 287383-59-9

Chemical Name:: SCRIPTAID

Synonyms: CS-1136;GCK 1026;Scriptide;Scriptaid (GCK1026);Scriptaid, Scriptide;Scriptaid, 10 mM in DMSO;Scriptaid, HDAC inhibitor;GCK 1026; SCRIPTIDE; GCK1026; GCK-1026;6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide;1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo-

CBNumber:: CB5504770

Molecular Formula:: C18H18N2O4

Molecular Weight:: 326.35

MDL Number:: MFCD00386477

MOL File:: 287383-59-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-22 18:57:36

Product description	Number	Pack Size	Price
Scriptaid ≥95%, solid	S7817	1MG	$164
Scriptaid ≥95%, solid	S7817	5MG	$558
Scriptaid - CAS 287383-59-9 - Calbiochem A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.	565730	5MG	$194
Scriptaid	C4037	100MG	$261
Scriptaid ≥98%	10572	1mg	$40
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SCRIPTAID Properties

Melting point	160-161 °C
Density	1.338±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 4 mg/ml).
form	Yellow solid.
pka	9.46±0.20(Predicted)
color	White
biological source	synthetic (organic)
Sensitive	Light Sensitive
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI	InChI=1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
InChIKey	JTDYUFSDZATMKU-UHFFFAOYSA-N
SMILES	C1(=O)C2=C3C(C=CC=C3C(=O)N1CCCCCC(NO)=O)=CC=C2
FDA UNII	EJQ8CD8BSV
UNSPSC Code	12352203
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

SCRIPTAID price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S7817	Scriptaid ≥95%, solid	287383-59-9	1MG	$164	2026-04-30	Buy
Sigma-Aldrich	S7817	Scriptaid ≥95%, solid	287383-59-9	5MG	$558	2026-04-30	Buy
Sigma-Aldrich	565730	Scriptaid - CAS 287383-59-9 - Calbiochem A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.	287383-59-9	5MG	$194	2022-05-15	Buy
TCI Chemical	C4037	Scriptaid	287383-59-9	100MG	$261	2026-04-30	Buy
Cayman Chemical	10572	Scriptaid ≥98%	287383-59-9	1mg	$40	2026-04-30	Buy

Product number	Packaging	Price	Buy
S7817	1MG	$164	Buy
S7817	5MG	$558	Buy
565730	5MG	$194	Buy
C4037	100MG	$261	Buy
10572	1mg	$40	Buy

SCRIPTAID Chemical Properties,Uses,Production

Description

Scriptaid is a histone deacetylase inhibitor that has an optimal concentration of 6-8 μM in a cell-based assay, is less toxic than trichostatin A, and works in a wide variety of biological systems. It induces cell cycle arrest in colon cancer cells in culture and inhibits tumor growth in vitro and in vivo. Scriptaid also facilitates the cloning of inbred mouse strains produced by somatic cell nuclear transfer.

Uses

Scriptaid has been used in post activation of oocytes and embryo culture.

Uses

Histone deacetylase inhibitor. A cell-permeable, relatively non-toxic HDAC inhibitor that facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner.

Definition

ChEBI: 6-(1,3-dioxo-2-benzo[de]isoquinolinyl)-N-hydroxyhexanamide is a member of isoquinolines.

General Description

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Biological Activity

Novel histone deacetylase inhibitor. Produces > 100-fold increase in histone acetylation and displays relatively low toxicity.

Biochem/physiol Actions

Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.

References

[1] G H SU. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.[J]. Cancer research, 2000, 60 12: 3137-3142.
[2] KELLY HUBER. Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells.[J]. The Journal of Biological Chemistry, 2011: 22211-22218. DOI:10.1074/jbc.m110.180224
[3] EUN JU LEE. Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells.[J]. International journal of oncology, 2008, 15 1: 767-776. DOI:10.3892/ijo\_00000063
[4] VITOR BRAGA RISSI. Inhibition of RNA synthesis during Scriptaid exposure enhances gene reprogramming in SCNT embryos.[J]. Reproduction, 2019, 157 2: 123-133. DOI:10.1530/rep-18-0366
[5] SONG HUANG. Scriptaid/exercise-induced lysine acetylation is another type of posttranslational modification occurring in titin.[J]. Journal of applied physiology, 2020: 276-285. DOI:10.1152/japplphysiol.00617.2019

SCRIPTAID Preparation Products And Raw materials

Raw materials

Preparation Products

SCRIPTAID Suppliers

Global( 150)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32466	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471;	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hebei Fengjia New Material Co., Ltd	+86-0311-87836622 +86-18712993135	sales01@tairunfaz.com	China	8051	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39039	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8615965530500	nickzhang@hangyubiotech.com	China	9952	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hebei Fengjia New Material Co., Ltd	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Zibo Hangyu Biotechnology Development Co., Ltd	58

View Lastest Price from SCRIPTAID manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-04-22	Scriptaid 287383-59-9	US $65.00-215.00 / mg		96.74%	10g	TargetMol Chemicals Inc.
	2020-01-10	6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide 287383-59-9	US $0.01 / KG	1KG	98%; 99%	500g;1kg； 25kg	Career Henan Chemical Co

Scriptaid
287383-59-9
US $65.00-215.00 / mg
96.74%
TargetMol Chemicals Inc.

6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
287383-59-9
US $0.01 / KG
98%; 99%
Career Henan Chemical Co

SCRIPTAID Spectrum

SCRIPTAID(287383-59-9)¹HNMR

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6-(1,3-dioxobenzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide GCK 1026; SCRIPTIDE; GCK1026; GCK-1026 CS-1136 GCK 1026 1H-Benz[de]isoquinoline-2(3H)-hexanamide, N-hydroxy-1,3-dioxo- Scriptide 6-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-N-hydroxyhexanaMide Scriptaid, Scriptide Scriptide N-Hydroxy-1,3-dioxo-1H-benz[de]isoquinoline-2(3H)-hexanamide Scriptaid (GCK1026) Scriptaid, HDAC inhibitor Scriptaid, 10 mM in DMSO N-?HYDROXY-?1,?3-?DIOXO-?1H-?BENZ[DE]ISOQUINOLINE-?2(3H)-?HEXANANMIDE 287383-59-9 Inhibitor Amines Aromatics Inhibitors Intermediates & Fine Chemicals Pharmaceuticals