OXAMFLATIN
- CAS No.
- 151720-43-3
- Chemical Name:
- OXAMFLATIN
- Synonyms
- CS-2473;Metacept 3;Oxamflatin【O3139】;METACEPT 3;OXAMFLATIN;Oxamflatin (Metacept-3);Oxamflatin, HDAC inhibitor;(E)-N-hydroxy-5-(3-(phenylsulfonaMido)phenyl)pent-2-en-4-ynaMide;(2E)-N-Hydroxy-5-[3-[(Phenylsulfonyl)Amino]Phenyl]-2-Penten-4-Ynamide;2-Penten-4-ynamide, N-hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-, (2E)-
- CBNumber:
- CB3504059
- Molecular Formula:
- C17H14N2O4S
- Molecular Weight:
- 342.37
- MDL Number:
- MFCD00949087
- MOL File:
- 151720-43-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 98-100°C |
|---|---|
| Density | 1.44±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 13 mg/mL, soluble |
| form | solid |
| pka | 7.75±0.10(Predicted) |
| color | Light yellow to yellow |
| Stability | Light sensitive |
| InChI | 1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+ |
| InChIKey | QRPSQQUYPMFERG-LFYBBSHMSA-N |
| SMILES | ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1 |
| UNSPSC Code | 12352203 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
OXAMFLATIN price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | O3139 | Oxamflatin ≥98% (HPLC), solid | 151720-43-3 | 1mg | $205 | 2026-04-30 | Buy |
| Sigma-Aldrich | O3139 | Oxamflatin ≥98% (HPLC), solid | 151720-43-3 | 5mg | $723 | 2026-04-30 | Buy |
| Cayman Chemical | 13176 | Oxamflatin ≥95% | 151720-43-3 | 1mg | $85 | 2026-04-30 | Buy |
| Cayman Chemical | 13176 | Oxamflatin ≥95% | 151720-43-3 | 5mg | $374 | 2026-04-30 | Buy |
| Cayman Chemical | 13176 | Oxamflatin ≥95% | 151720-43-3 | 10mg | $663 | 2026-04-30 | Buy |
OXAMFLATIN Chemical Properties, Uses, Production
Chemical Properties
Red-Brown Solid
Uses
Histone deacetylase inhibitor. A cell-permeable, aromatic sulfonamide derivative with a hydroxamic acid group that potently inhibits mammalian HDAC by binding to the active site zinc.
Definition
ChEBI: 5-[3-(benzenesulfonamido)phenyl]-N-hydroxypent-2-en-4-ynamide is a sulfonamide.
Biological Activity
Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.', 'Histone deacetylase inhibitor; anti-cancer agent.
Enzyme inhibitor
This anti-tumor agent (FW = 342.38 g/mol; CAS 151720-43-3; Solubility: 13 mg/mL DMSO, methanol, acetonitrile, 10 mg/mL), also known as (2E)- 5-[3-[(phenylsulfonyl)amino]phenyl]-pent-2-en-4-ynohydroxamate, inhibits histone deacetylase. Oxamflatin shows antiproliferative activity in vitro against various mouse and human tumor cell lines, attended by drastic changes in the cell morphology and in vivo antitumor activity against B16 melanoma. Oxamflatin causes an elongated cell shape with filamentous protrusions as well as arrest of the cell cycle at the G1 phase in HeLa cells. These phenotypic changes in HeLa cells were similar to those induced by trichostatin A (TSA), a specific inhibitor of histone deacetylase (HDAC).
OXAMFLATIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Hubei Chuangliankangcheng Pharmaceutical Co., Ltd. | 027-65388397 18164111589 | 3321478047@qq.com | China | 2002 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
View Latest Price from OXAMFLATIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | Oxamflatin
151720-43-3
|
$56.00-156.00 | 98.25% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-25 | Oxamflatin
151720-43-3
|
$100.00 | 1KG | 98% | 100KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | Oxamflatin
151720-43-3
|
$100.00 | 1KG | 99% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- Oxamflatin
151720-43-3
- $56.00-156.00
- 98.25%
- TargetMol Chemicals Inc.
-
- Oxamflatin
151720-43-3
- $100.00
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- Oxamflatin
151720-43-3
- $100.00
- 99%
- Hong Kong Tiansheng New Material Trading Co., Ltd
