Swertisin
- CAS No.
- 6991-10-2
- Chemical Name:
- Swertisin
- Synonyms
- Tris(1;SWERTISIN;SWERTISIN(P);Swertisin-RM;Swertia flavin;Genkwanin 6-C-Glucoside;Swertisin, 10 mM in DMSO;3-dichloroisopropyl)phosphate;APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER;4',5-Dihydroxy-7-methoxy-6-β-D-glucopyranosylflavone
- CBNumber:
- CB5724709
- Molecular Formula:
- C22H22O10
- Molecular Weight:
- 446.4
- MDL Number:
- MFCD32003920
- MOL File:
- 6991-10-2.mol
- MSDS File:
- SDS
| Melting point | 245-246℃ |
|---|---|
| Boiling point | 716.6±60.0 °C(Predicted) |
| Density | 1.583±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Soluble in DMSO; sparingly soluble in methanol; |
| form | powder |
| pka | 5.76±0.40(Predicted) |
| color | White-pale yellow |
| Water Solubility | slightly soluble in water |
| Major Application | food and beverages |
| InChI | 1S/C22H22O10/c1-30-13-7-14-16(11(25)6-12(31-14)9-2-4-10(24)5-3-9)19(27)17(13)22-21(29)20(28)18(26)15(8-23)32-22/h2-7,15,18,20-24,26-29H,8H2,1H3 |
| InChIKey | ABRULANJVVJLFI-UHFFFAOYSA-N |
| SMILES | O1C(C(C(C(C1c2c(c3c(cc2OC)OC(=CC3=O)c4ccc(cc4)O)O)O)O)O)CO |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
Swertisin price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL83912 | Swertisin phyproof? Reference Substance | 6991-10-2 | 10MG | $595 | 2026-04-30 | Buy |
| Cayman Chemical | 34744 | Swertisin ≥98% | 6991-10-2 | 1mg | $83 | 2026-04-30 | Buy |
| Cayman Chemical | 34744 | Swertisin ≥98% | 6991-10-2 | 5mg | $330 | 2026-04-30 | Buy |
| Cayman Chemical | 34744 | Swertisin ≥98% | 6991-10-2 | 10mg | $578 | 2026-04-30 | Buy |
| Cayman Chemical | 34744 | Swertisin ≥98% | 6991-10-2 | 25mg | $1032 | 2026-04-30 | Buy |
Swertisin Chemical Properties, Uses, Production
Chemical Properties
Swertisin is a flavonoid compound that appears as a light yellow powder or crystalline powder at room temperature. Its chemical formula is C22H22O10, with a molecular weight of 446. it is soluble in organic solvents such as methanol and dimethyl sulfoxide. It has antioxidant,anti-diabetic, anti-depressant, anti-inflammatory, anti-viral, and anti-radiation pharmacological effects.
Uses
food and beverages
Definition
ChEBI: Swertisin is a flavone C-glycoside that is 7-O-methylapigenin in which the hydrogen at position 6 has been replaced by a beta-D-glucosyl residue. It has a role as a plant metabolite, an adenosine A1 receptor antagonist, an anti-inflammatory agent, an antioxidant and a hypoglycemic agent. It is a flavone C-glycoside, a monosaccharide derivative, a polyphenol, a monomethoxyflavone and a dihydroxyflavone. It is functionally related to an apigenin.
Biological Activity
Swertisin is a flavonoid C-glycoside that has been found in Swertia japonica and has diverse biological activities. It inhibits sodium-glucose cotransporter 2 (SGLT2) in HEK293 cells when used at a concentration of 7.5 μg/ml and is an adenosine A1 receptor antagonist (IC50 = 137 μM). Swertisin (0.2-5 μM) inhibits hepatitis B virus (HBV) replication in HepG2 2.2.15 cells. It decreases blood glucose levels in a mouse model of diabetes induced by streptozotocin (Item No. 13104), as well as prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.
in vivo
Swertisin (30 mg/kg, orally, single dose) helps improve symptoms of schizophrenia in mice, including sensory motor gating disruptions and cognitive impairments[1].
Swertisin (2.5 mg/kg, intraperitoneally, once daily, days) reduces the expression of SGLT2 in mouse kidney tissue and can quickly lower blood sugar[2].
Swertisin (0-10 mg/kg, intraperitoneally, every other day, 20 days) significantly inhibits HBV replication in a HBV transgenic mouse model[3].
| Animal Model: | Mice induced by MK801 (HY-15084B)[1] |
| Dosage: | 30 mg/kg; single dose |
| Administration: | Oral gavage (p.o.) |
| Result: | Alleviated the pre-pulse inhibition defect, reversed memory recognition impairment, and the elevated phosphorylation levels of Akt and GSK-3β signaling molecules in the prefrontal cortex restore normal function. |
| Animal Model: | BALB/c mice induced by STZ (HY-13753)[2] |
| Dosage: | 2.5 mg/kg; daily; 15 days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Improved overall glucose homeostasis, reduced SGLT2 expression in renal tissue, reduced PKC expression, and had a rapid hypoglycemic effect. |
| Animal Model: | HBV transgenic mice[3] |
| Dosage: | 0, 5, 10 mg/kg; every other day; 20 days |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Showed that there was no significant weight loss, no significant changes in serum ALT and AST levels, and reduced serum HBsAg and HBeAg levels. |
IC 50
SGLT2
References
[1] GURPRIT BHARDWAJ . Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy[J]. Archives of biochemistry and biophysics, 2021, 710: Article 108995. DOI:10.1016/j.abb.2021.108995.
[2] K. PATEL D. P. Biological importance and therapeutic benefit of swertisin: An overview of medicinal importance and pharmacological activities[J]. Current Bioactive Compounds, 2022. DOI:10.2174/1573407218666220801113334.
[3] HONG-YAN XU . Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim[J]. Journal of ethnopharmacology, 2020, 257: Article 112787. DOI:10.1016/j.jep.2020.112787.
Swertisin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Cheng Du Pufeide Biotechnology Co., Ltd. | 028-82610909 13388174823 | scglp@glp-china.com | China | 1064 | 58 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Shanghai Aspire Biological Technology Co., Ltd. | 021-61317773 | sales@aspirebio.com | China | 2880 | 58 |
| Shanghai Yongye Biotechnology Co., Ltd. | 86-021-61559134 15921386130 | 3423497944@qq.com | China | 8135 | 55 |
| ALB Technology Limited | 702-983-3769 | sales@albtechnology.com | United States | 2992 | 55 |
View Latest Price from Swertisin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | Swertisin
6991-10-2
|
$64.00-393.00 | 99.89% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Swertisin
6991-10-2
|
20mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2020-02-21 | APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER
6991-10-2
|
$8.00 | 1g | ＞98% HPLC | Career Henan Chemical Co |
-
- Swertisin
6991-10-2
- $64.00-393.00
- 99.89%
- TargetMol Chemicals Inc.
-
- Swertisin
6991-10-2
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER
6991-10-2
- $8.00
- ＞98% HPLC
- Career Henan Chemical Co
