2-((4-Chlorophenyl)acetyl)benzoic acid
- CAS No.
- 53242-76-5
- Chemical Name:
- 2-((4-Chlorophenyl)acetyl)benzoic acid
- Synonyms
- 2-[2-(4-chlor;Einecs 258-444-8;AZELASTINE EP IMP C;Azelastine Impurity C;Azelastine EP IMpurity C;Azelastine HCl EP Impurity C;Chlorophenylacetylbenzoic acid;2-(p-Chlorphenacetyl)-Benzoesaeure;2-(4-CHLOROPHENYLACETO)BENZOIC ACID;2-[(4-Chlorophenyl)acetyl]benzoic A
- CBNumber:
- CB5735002
- Molecular Formula:
- C15H11ClO3
- Molecular Weight:
- 274.7
- MDL Number:
- MFCD07369702
- MOL File:
- 53242-76-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 137-141°C |
|---|---|
| Boiling point | 456.8±30.0 °C(Predicted) |
| Density | 1.332±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.36±0.36(Predicted) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C15H11ClO3/c16-11-7-5-10(6-8-11)9-14(17)12-3-1-2-4-13(12)15(18)19/h1-8H,9H2,(H,18,19) |
| InChIKey | BDSINYHJZLINDJ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=CC=C1C(CC1=CC=C(Cl)C=C1)=O |
| CAS DataBase Reference | 53242-76-5(CAS DataBase Reference) |
| FDA UNII | 32I72UN2JY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
2-((4-Chlorophenyl)acetyl)benzoic acid price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-C375450-2.5G | 2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC) | 53242-76-5 | 2.5g | $238 | 2026-06-03 | Buy |
| TRC | TRC-C375450-1G | 2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC) | 53242-76-5 | 1g | $156 | 2026-06-03 | Buy |
| TRC | TRC-C375450-10G | 2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC) | 53242-76-5 | 10g | $683 | 2026-06-03 | Buy |
| Biosynth | FC151136 | 2-(4-Chlorophenyl-acetyl)benzoic acid | 53242-76-5 | 250g | $687.5 | 2026-06-04 | Buy |
| Biosynth | FC151136 | 2-(4-Chlorophenyl-acetyl)benzoic acid | 53242-76-5 | 500g | $965 | 2026-06-04 | Buy |
2-((4-Chlorophenyl)acetyl)benzoic acid Chemical Properties, Uses, Production
Uses
2-[(4-Chlorophenyl)acetyl]benzoic Acid is an impurity of Azelastine (A808250).
Uses
2-[(4-Chlorophenyl)acetyl]benzoic Acid (Azelastine EP Impurity C) is an impurity of Azelastine (A808250).
Synthesis
1878-66-6
85-44-9
53242-76-5
P-chlorobenzene acetic acid, phthalic anhydride and freshly melted sodium acetate were added to the reaction kettle in a certain ratio. The reaction was rapidly heated to about 250 °C and continuously stirred at 240-250 °C for 3 h. The water generated during the reaction was discharged through the tail of the reactor. Subsequently, the reaction mixture was transferred to an open heat-resistant vessel and continued to be heated. After the reaction mixture cooled, cold anhydrous ethanol was added. The mixture was heated until the solid was as dissolved as possible, then cooled and filtered. The filter cake was washed with anhydrous ethanol, filtered again and dried. The dried solid was dissolved in aqueous sodium hydroxide solution and stirred under reflux conditions for 4 hours. After completion of the reaction, the mixture was cooled, diluted with water and acidified with 20% hydrochloric acid to pH 2-3. After stirring and cooling, a solid oily precipitate was formed. The precipitate was filtered and dried to give the crude product. The crude product was evaporated from acetone by dissolving in acetone and filtering out the insoluble material. The residue was recrystallized with ethyl acetate to give the final target product 2-(4-chlorophenylacetyl)benzoic acid. The product had a melting point of 142-144 °C and a yield of 80%.
References
[1] Patent: CN108003005, 2018, A. Location in patent: Paragraph 0010; 0011; 0012
2-((4-Chlorophenyl)acetyl)benzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Anhui Qiushi Medical Technology Co., Ltd | 15005516438 | sales1@qiushipharm.com | China | 51 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-4000505016 13380397412 | 3001272453@qq.com | China | 5000 | 50 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
View Latest Price from 2-((4-Chlorophenyl)acetyl)benzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-27 | 2-((4-Chlorophenyl)acetyl)benzoic acid
53242-76-5
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2021-07-13 | N-(2,3-epoxypropyl)phthalimide
53242-76-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | N-(2,3-epoxypropyl)phthalimide
53242-76-5
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 2-((4-Chlorophenyl)acetyl)benzoic acid
53242-76-5
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- N-(2,3-epoxypropyl)phthalimide
53242-76-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- N-(2,3-epoxypropyl)phthalimide
53242-76-5
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
