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2-((4-Chlorophenyl)acetyl)benzoic acid

2-((4-Chlorophenyl)acetyl)benzoic acid structure

CAS No.: 53242-76-5

Chemical Name:: 2-((4-Chlorophenyl)acetyl)benzoic acid

Synonyms: 2-[2-(4-chlor;Einecs 258-444-8;AZELASTINE EP IMP C;Azelastine Impurity C;Azelastine EP IMpurity C;Azelastine HCl EP Impurity C;Chlorophenylacetylbenzoic acid;2-(p-Chlorphenacetyl)-Benzoesaeure;2-(4-CHLOROPHENYLACETO)BENZOIC ACID;2-[(4-Chlorophenyl)acetyl]benzoic A

CBNumber:: CB5735002

Molecular Formula:: C15H11ClO3

Molecular Weight:: 274.7

MDL Number:: MFCD07369702

MOL File:: 53242-76-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:16:59

Product description	Number	Pack Size	Price
2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC)	TRC-C375450-2.5G	2.5g	$238
2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC)	TRC-C375450-1G	1g	$156
2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC)	TRC-C375450-10G	10g	$683
2-(4-Chlorophenyl-acetyl)benzoic acid	FC151136	250g	$687.5
2-(4-Chlorophenyl-acetyl)benzoic acid	FC151136	500g	$965
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2-((4-Chlorophenyl)acetyl)benzoic acid Properties

Melting point	137-141°C
Boiling point	456.8±30.0 °C(Predicted)
Density	1.332±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
pka	3.36±0.36(Predicted)
form	Solid
color	White to Off-White
InChI	InChI=1S/C15H11ClO3/c16-11-7-5-10(6-8-11)9-14(17)12-3-1-2-4-13(12)15(18)19/h1-8H,9H2,(H,18,19)
InChIKey	BDSINYHJZLINDJ-UHFFFAOYSA-N
SMILES	C(O)(=O)C1=CC=CC=C1C(CC1=CC=C(Cl)C=C1)=O
CAS DataBase Reference	53242-76-5(CAS DataBase Reference)
FDA UNII	32I72UN2JY

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

2-((4-Chlorophenyl)acetyl)benzoic acid price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-C375450-2.5G	2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC)	53242-76-5	2.5g	$238	2026-06-03	Buy
TRC	TRC-C375450-1G	2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC)	53242-76-5	1g	$156	2026-06-03	Buy
TRC	TRC-C375450-10G	2-[(4-Chlorophenyl)acetyl]benzoic Acid >95%(HPLC)	53242-76-5	10g	$683	2026-06-03	Buy
Biosynth	FC151136	2-(4-Chlorophenyl-acetyl)benzoic acid	53242-76-5	250g	$687.5	2026-06-04	Buy
Biosynth	FC151136	2-(4-Chlorophenyl-acetyl)benzoic acid	53242-76-5	500g	$965	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-C375450-2.5G	2.5g	$238	Buy
TRC-C375450-1G	1g	$156	Buy
TRC-C375450-10G	10g	$683	Buy
FC151136	250g	$687.5	Buy
FC151136	500g	$965	Buy

2-((4-Chlorophenyl)acetyl)benzoic acid Chemical Properties,Uses,Production

Uses

2-[(4-Chlorophenyl)acetyl]benzoic Acid is an impurity of Azelastine (A808250).

Uses

2-[(4-Chlorophenyl)acetyl]benzoic Acid (Azelastine EP Impurity C) is an impurity of Azelastine (A808250).

Synthesis

1878-66-6

85-44-9

53242-76-5

P-chlorobenzene acetic acid, phthalic anhydride and freshly melted sodium acetate were added to the reaction kettle in a certain ratio. The reaction was rapidly heated to about 250 °C and continuously stirred at 240-250 °C for 3 h. The water generated during the reaction was discharged through the tail of the reactor. Subsequently, the reaction mixture was transferred to an open heat-resistant vessel and continued to be heated. After the reaction mixture cooled, cold anhydrous ethanol was added. The mixture was heated until the solid was as dissolved as possible, then cooled and filtered. The filter cake was washed with anhydrous ethanol, filtered again and dried. The dried solid was dissolved in aqueous sodium hydroxide solution and stirred under reflux conditions for 4 hours. After completion of the reaction, the mixture was cooled, diluted with water and acidified with 20% hydrochloric acid to pH 2-3. After stirring and cooling, a solid oily precipitate was formed. The precipitate was filtered and dried to give the crude product. The crude product was evaporated from acetone by dissolving in acetone and filtering out the insoluble material. The residue was recrystallized with ethyl acetate to give the final target product 2-(4-chlorophenylacetyl)benzoic acid. The product had a melting point of 142-144 °C and a yield of 80%.

References

[1] Patent: CN108003005, 2018, A. Location in patent: Paragraph 0010; 0011; 0012

2-((4-Chlorophenyl)acetyl)benzoic acid Preparation Products And Raw materials

Raw materials

4-Chlorophenylacetic acid Phthalic anhydride Sodium hydroxide Water

Preparation Products

2-((4-Chlorophenyl)acetyl)benzoic acid Suppliers

Global( 236)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6366	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Dideu Industries Group Limited	+86-86-15536356810 +8617392712697	1022@dideu.com	China	29068	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58

View Lastest Price from 2-((4-Chlorophenyl)acetyl)benzoic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-27	2-((4-Chlorophenyl)acetyl)benzoic acid 53242-76-5		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2021-07-13	N-(2,3-epoxypropyl)phthalimide 53242-76-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2021-07-10	N-(2,3-epoxypropyl)phthalimide 53242-76-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd

2-((4-Chlorophenyl)acetyl)benzoic acid
53242-76-5
99%
Hebei Chuanghai Biotechnology Co., Ltd

N-(2,3-epoxypropyl)phthalimide
53242-76-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

N-(2,3-epoxypropyl)phthalimide
53242-76-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

2-((4-Chlorophenyl)acetyl)benzoic acid Spectrum

2-((4-Chlorophenyl)acetyl)benzoic acid(53242-76-5)¹HNMR

53242-76-5(2-((4-Chlorophenyl)acetyl)benzoic acid)Related Search:

1,2,4-Trichlorobenzene 4-Aminobenzoic acid Acetylacetone Acetyl coenzyme A sodium salt Azelastine-d4 HCl

4-Acetylbenzoic acid Acetyl chloride N-ACETYL-L-TYROSINE ETHYL ESTER Benzoic acid tributyl acetocitrate

Anthranilic acid Azelastine azelastine hydrochloride Azelastine Hydrochloride IMpurity D Azelastine EP Impurity E

Benzoyl hydrazine 4-(4-CHLOROBENZYL)-2-(2-(1-METHYLPYRROLIDIN-2-YL)ETHYL)PHTHALAZIN-1(2H)-ONE Benzoic acid, 2-(hexahydro-1-Methyl-1H-azepin-4-yl)hydrazide

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2-(4-CHLOROPHENYL-ACETYL)BENZOIC ACID 2-(4-CHLOROPHENYLACETO)BENZOIC ACID 2-[2-(4-Chlorophenyl)acetyl]benzoic acid 2-[(4-CHLOROPHENYL) ACETYL] BENZOIC ACID,98+% 2-(2-(4-CHLOROPHENYL)-2-OXOETHYL)BENZOIC ACID Einecs 258-444-8 Azelastine EP IMpurity C 2-[2-(4-chlorophenyl)-acetyl]-benzoic acid (intermediate of azelastine hcl) Azelastine HCl EP Impurity C Chlorophenylacetylbenzoic acid NA###2-((4-Chlorophenyl)acetyl)benzoic acid Benzoic acid,2-[2-(4-chlorophenyl)acetyl]- Azelastine Impurity C 2-[(4-Chlorophenyl)acetyl]benzoic Acid, >=99% 2-[2-(4-chlor 2-[2-(4-chlorophenyl)-1-oxoethyl]benzoic acid 2-(p-Chlorphenacetyl)-Benzoesaeure Azelastine Impurity 5(EP Impurity C) 2-[(4-Chlorophenyl)acetyl]benzoic A Azelastine Impurity 5(Azelastine EP Impurity C) Azelastine Hydrochloride Impurity C Azelastine Hydrochloride EP Impurity C 2-(2-(4-Chlorophenyl)acetyl)benzoicaci AZELASTINE EP IMP C 2-(2-(4-Chlorophenyl)acetyl)benzoic acid (Azelastine Impurity) 10. : 2-((4-Chlorophenyl)acetyl)benzoic acid 53242-76-5 C15Cl11ClO3 Aromatics Impurities Intermediates & Fine Chemicals Pharmaceuticals Organic acids (intermediate of azelastine hcl)