5-(4-Hydroxyphenyl)-2,4-imidazolidinedione
- CAS No.
- 2420-17-9
- Chemical Name:
- 5-(4-Hydroxyphenyl)-2,4-imidazolidinedione
- Synonyms
- 4-HYDROXYPHENYL HYDANTOIN;5-(4-hydroxyphenyl)imidazolidine-2,4-dione;P-hydantoin;RARECHEM AP KH 0026;Hydantoin Impurity 29;Hydroxyphenylhydantoin;4-Hydroxyphenyhydantoin;4-Hydroxybenzohydantoin;p-Hydroxyphenylhydantoin;DL-p-Hydroxybenzohydantoin
- CBNumber:
- CB5779592
- Molecular Formula:
- C9H8N2O3
- Molecular Weight:
- 192.17
- MDL Number:
- MFCD00044002
- MOL File:
- 2420-17-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | >260°C |
|---|---|
| Boiling point | 273.7℃[at 101 325 Pa] |
| Density | 1.408 |
| vapor pressure | 0Pa at 25℃ |
| storage temp. | Inert atmosphere,Room Temperature |
| form | powder to crystal |
| pka | 8.67±0.10(Predicted) |
| color | White to Almost white |
| Water Solubility | 1.29g/L at 20℃ |
| InChI | InChI=1S/C9H8N2O3/c12-6-3-1-5(2-4-6)7-8(13)11-9(14)10-7/h1-4,7,12H,(H2,10,11,13,14) |
| InChIKey | UMTNMIARZPDSDI-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(C2=CC=C(O)C=C2)C(=O)N1 |
| LogP | -0.03 at 20℃ |
| CAS DataBase Reference | 2420-17-9(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS07,GHS09 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302+H312-H315-H318-H411 | |||||||||
| Precautionary statements | P264-P270-P273-P280-P301+P312+P330-P302+P352+P312-P305+P351+P338+P310-P332+P313-P391-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 26-39 | |||||||||
| RIDADR | UN3077 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 2933.21.0000 | |||||||||
| HazardClass | 9 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Aquatic Acute 1 Aquatic Chronic 1 |
|||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H0806 | 5-(4-Hydroxyphenyl)hydantoin >98.0%(N) | 2420-17-9 | 5g | $28 | 2026-04-30 | Buy |
| TCI Chemical | H0806 | 5-(4-Hydroxyphenyl)hydantoin >98.0%(N) | 2420-17-9 | 25g | $114 | 2024-03-01 | Buy |
| Chem-Impex | 42971 | 5-(4-Hydroxyphenyl)hydantoin ≥98% | 2420-17-9 | 5G | $60.79 | 2026-05-19 | Buy |
| Chem-Impex | 42971 | 5-(4-Hydroxyphenyl)hydantoin ≥98% | 2420-17-9 | 25G | $206.21 | 2026-05-19 | Buy |
| Synthonix | H51419 | 5-(4-Hydroxyphenyl)imidazolidine-2,4-dione 98% | 2420-17-9 | 1g | $12 | 2026-05-06 | Buy |
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione Chemical Properties, Uses, Production
Uses
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione is used in the synthesis of D-p-hydroxyphenylglycine, it is an important pharmaceutical intermediate in the production of amoxicillin, cephalosporins, etc. As a side chain of β-lactam semi-synthetic antibiotics, it is used in the production of antibiotics such as amoxicillin, which have broad-spectrum antibacterial properties and are convenient to use.
Flammability and Explosibility
Non flammable
Synthesis
Add 4.0 g of glyoxylic acid monohydrate (0.04 mol), 1.2 g of urea (0.02 mol), and 10 mL of 10% hydrochloric acid into the beaker. Stir evenly. After releasing the heat, pour it into a dropping funnel and set aside. Add 3.6 g (0.06 mol) of urea, 5.6 g (0.06 mol) of phenol, and 10% hydrochloric acid, and stir evenly in a three-necked flask. Heat to 90 ℃, slowly add the glyoxylic acid-urea mixture dropwise and control the dropping speed for about 4 hours. After the dropwise addition is completed, continue the heat preservation reaction for 2 hours to complete the reaction. Change the reaction device to a vacuum distillation device to recover excess phenol. After evaporating about 1/3 of the volume of the solution, cool to about 15°C to crystallize, filter, and use the filter cake. Wash with water 2 to 3 times until neutral and dry to obtain 5.8 g of white solid 5-(4-Hydroxyphenyl)-2,4-imidazolidinedione.
5-(4-Hydroxyphenyl)-2,4-imidazolidinedione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Mingde Biotechnology Co., Ltd | 15553348166 | m15553348166@163.com | China | 2027 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from 5-(4-Hydroxyphenyl)-2,4-imidazolidinedione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 4-Hydroxyphenyl hydantoin
2420-17-9
|
$55.00-550.00 | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2026-06-30 | 5-(4-Hydroxyphenyl)-2,4-imidazolidinedione
2420-17-9
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | 4-Hydroxyphenyl Hydantoin
2420-17-9
|
$19.00 | 1KG | 99.% | 50 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- 4-Hydroxyphenyl hydantoin
2420-17-9
- $55.00-550.00
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- 5-(4-Hydroxyphenyl)-2,4-imidazolidinedione
2420-17-9
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 4-Hydroxyphenyl Hydantoin
2420-17-9
- $19.00
- 99.%
- Hebei Chuanghai Biotechnology Co,.LTD
