5-Fluoro-3-methyl-pyridin-2-ylamine
- CAS No.
- 886365-56-6
- Chemical Name:
- 5-Fluoro-3-methyl-pyridin-2-ylamine
- Synonyms
- 2-Amino-5-fluoro-3-methylpyridine;2-AMINO-5-FLUORO-3-PICOLINE;5-fluoro-3-Methyl-2-pyridinaMine;5-Fluoro-3-methylpyridin-2-amine;2-Pyridinamine, 5-fluoro-3-methyl-;5-Fluoro-3-methyl-pyridin-2-ylamine;5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE ISO 9001：2015 REACH
- CBNumber:
- CB5798511
- Molecular Formula:
- C6H7FN2
- Molecular Weight:
- 126.13
- MDL Number:
- MFCD07375130
- MOL File:
- 886365-56-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| HS Code | 2933399990 |
5-Fluoro-3-methyl-pyridin-2-ylamine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC911092 | 5-Fluoro-3-methylpyridin-2-ylamine >98% | 886365-56-6 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC911092 | 5-Fluoro-3-methylpyridin-2-ylamine >98% | 886365-56-6 | 1g | $39 | 2026-06-04 | Buy |
| Apolloscientific | PC911092 | 5-Fluoro-3-methylpyridin-2-ylamine >98% | 886365-56-6 | 5g | $146 | 2026-06-04 | Buy |
| Apolloscientific | PC911092 | 5-Fluoro-3-methylpyridin-2-ylamine >98% | 886365-56-6 | 25g | $682 | 2026-06-04 | Buy |
| Apolloscientific | PC911092 | 5-Fluoro-3-methylpyridin-2-ylamine >98% | 886365-56-6 | 100g | $2590 | 2026-06-04 | Buy |
5-Fluoro-3-methyl-pyridin-2-ylamine Chemical Properties, Uses, Production
Synthesis
38186-84-4
886365-56-6
To a solution of 2-chloro-3-methyl-5-fluoropyridine (0.50 g, 2.82 mmol) in anhydrous toluene (12.5 mL) was added sequentially sodium tert-butoxide (0.462 g, 4.81 mmol), tris(dibenzylideneacetone)dipalladium (0.315 g, 0.344 mmol), 2,2'-bis(diphenylphosphinato)-1,1'-binaphthyl ( BINAP, 0.642 g, 1.031 mmol) and benzophenoneimine (0.692 mL, 4.12 mmol). The reaction mixture was degassed (three evacuation/nitrogen filling cycles) and subsequently heated to 80 °C and stirred for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with ether (400 mL) and filtered through a pad of diatomaceous earth. The filtrate was concentrated under reduced pressure and the residue was dissolved in tetrahydrofuran (34 mL) and 2 M aqueous hydrochloric acid (1.408 mL, 2.82 mmol) was added. After stirring for 1.5 h at room temperature, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate and diluted with dichloromethane (200 mL). The aqueous phase was back-extracted with dichloromethane (2 x 50 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel (Biotage SP4 12M, cyclohexane/ethyl acetate 60/40). The target fraction was collected to give 2-amino-3-methyl-5-fluoropyridine (0.20 g, 1.554 mmol, 55.2% overall yield in two steps) as an orange solid. Mass spectrum (electrospray positive ion mode) m/z: 127 ([M+H]+). Elemental analysis calculated value (C6H7FN2): 126.1. 1H NMR (400 MHz, DMSO-d6) δ (ppm): 7.73 (d, 1H), 7.23 (dd, 1H), 5.60 (broad peak, 2H), 2.04 (s, 3H).
References
[1] Patent: US2009/22670, 2009, A1. Location in patent: Page/Page column 20
[2] Patent: WO2010/72722, 2010, A1. Location in patent: Page/Page column 27
5-Fluoro-3-methyl-pyridin-2-ylamine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Hebei Summedchem Co.,Ltd | 0319-5801333-8008 15630992918 | sales@summedchem.com | China | 1000 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ChongQing Purel Bio-Pharmaceutical Technology Co., Ltd. | 023-89130144 18523560356 | zhyong1011@163.com | China | 297 | 58 |
View Latest Price from 5-Fluoro-3-methyl-pyridin-2-ylamine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-25 | 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE
886365-56-6
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE
886365-56-6
|
$1.00 | 1kg | 98% | 200KG | Career Henan Chemical Co |
-
- 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE
886365-56-6
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 5-FLUORO-3-METHYL-PYRIDIN-2-YLAMINE
886365-56-6
- $1.00
- 98%
- Career Henan Chemical Co
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