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ChemicalBook >> CAS DataBase List >>Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate

Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate

Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate Structure
Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate structure
CAS No.
100491-29-0
Chemical Name:
Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate
Synonyms
ETHYL 1-(2;RRR-α-Tocopherolum;Tosufloxacin Impurity;Tosufloxacin Impurity 2;3-B] PYRIDINE-3-CARBOXYLATE;Ethyl 7-chloro-1-(2,4-difluorophenyl);4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2;-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate;ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYR...;ethyl1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxohydropyridino
CBNumber:
CB2461449
Molecular Formula:
C17H10ClF3N2O3
Molecular Weight:
382.72
MDL Number:
MFCD01863285
MOL File:
100491-29-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:18
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Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate Properties

Melting point 212-215 °C
Boiling point 502.5±50.0 °C(Predicted)
Density 1.4752 (estimate)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
form Solid
pka -3.23±0.70(Predicted)
color White to Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)Environment (GHS09)
GHS07,GHS09
Signal word  Warning
Hazard statements  H317-H411
Precautionary statements  P501-P261-P273-P272-P280-P302+P352-P391-P362+P364-P333+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  37/39-26
HS Code  29339980
REACH Registrations Inactive
NFPA 704
0
2 0

Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical E1180 Ethyl 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate >98.0%(HPLC)(N) 100491-29-0 5g $35 2026-04-30 Buy
TCI Chemical E1180 Ethyl 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate >98.0%(HPLC)(N) 100491-29-0 25g $104 2026-04-30 Buy
TRC TRC-C366350-5G 7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 100491-29-0 5g $167 2026-06-03 Buy
TRC TRC-C366350-1G 7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 100491-29-0 1g $65 2026-06-03 Buy
TRC TRC-C366350-10G 7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 100491-29-0 10g $294 2026-06-03 Buy
Product number Packaging Price Buy
E1180 5g $35 Buy
E1180 25g $104 Buy
TRC-C366350-5G 5g $167 Buy
TRC-C366350-1G 1g $65 Buy
TRC-C366350-10G 10g $294 Buy

Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate Chemical Properties, Uses, Production

Chemical Properties

almost white powder

Uses

An intermediate of Trovafloxacin (T893000) and analogs.

Synthesis

3-Pyridinepropanoic acid, 2-[(2,4-difluorophenyl)amino]-5-fluoro-6-methoxy-β-oxo-, ethyl ester

105152-47-4

ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE

100491-29-0

(1) 250 mg of phosphoryl chloride was slowly added dropwise to 4 mL of N,N-dimethylformamide followed by 200 mg of 2-[2-(2,4-difluorophenylamino)-5-fluoro-6-methoxynicotinoyl]ethyl acetate under cooling conditions in an ice bath and stirred for 10 min keeping the same temperature. Next, ethyl acetate was added to the reaction mixture. The reaction system was warmed up to 50-60°C for 3.5 hours. Upon completion of the reaction, the mixture was poured into 50 mL of ice water and extracted by adding 20 mL of chloroform, the organic layer was separated, washed with 20 mL of water and subsequently dried with anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure, 5 mL of ether was added to the residue, and the crystals were collected by filtration to afford 150 mg (72.2% yield) of ethyl 7-chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-diazanaphthalene-3-carboxylate, melting point 217-220 °C. The solvent was concentrated under reduced pressure. Crystals with melting points of 219-221°C were obtained by recrystallization from acetone-methanol solvent mixture (1:1, v/v). Elemental analysis (C17H10N2O3ClF3) Calculated values (%): C, 53.35; H, 2.63; N, 7.32. Measured values (%): C, 53.61; H, 2.47; N, 6.96.

References

[1] Patent: US4704459, 1987, A

Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

3-Pyridinepropanoic acid, 2-[(2,4-difluorophenyl)amino]-5-fluoro-6-methoxy-β-oxo-, ethyl ester Ethyl-2-(2,6-dichlor-5-fluorpyridin-3-carbonyl)-3-(2,4-difluorphenylamino)-acrylat Water Diethyl ether trichlorophosphate
N,N-Dimethylformamide Chloroform

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Preparation Products

Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate Suppliers

Global Suppliers ( 149)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Chemexcel (Zhangjiakou) Fine Chemicals Co., Ltd 86-10-62944695-809 sales@chemexcel.com.cn China 80 62
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
Beijing Isomersyn Technology CO;LTD 010-82954736 13391601435 sales@isomersyn.com China 3294 57
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Hunan Hui Bai Shi Biotechnology Co., Ltd. 0731-85526065 13308475853 ivy@hnhbsj.com China 7236 62
Tongchuang Pharma(Suzhou). Co., Ltd. 0512-63263366 18912765016 tongtf110@sina.com China 984 62
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Chemexcel (Zhangjiakou) Fine Chemicals Co., Ltd 62
Energy Chemical 61
Jia Xing Isenchem Co.,Ltd 66
Chemsky (shanghai) International Co.,Ltd 60
Beijing Isomersyn Technology CO;LTD 57
Shanghai Ennopharm Co., Ltd. 65
Hunan Hui Bai Shi Biotechnology Co., Ltd. 62
Tongchuang Pharma(Suzhou). Co., Ltd. 62

View Latest Price from Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE pictures 2026-08-20 ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE
100491-29-0
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE pictures 2025-12-29 ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE
100491-29-0
 1kg 99% Changzhou waston chemical technology Co.,Ltd
Tosufloxacin Impurity pictures 2025-12-16 Tosufloxacin Impurity
100491-29-0
 10mg 95%+ 100000 Moxin Chemicals

100491-29-0 (Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate) Related Search:

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ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CL-6-F-4-O-HYDROPYRIDINO[2,3-B]PYRIDINE-3-CARBOXYLATE Ethyl 1-(2,4-difluorophenyl)-7-Cl-6-F-4-O-hydropyridino[2,3-b]pyridine-3-carboxylate,99% Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate Ethyl 1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxohydropyridino[2,3-b]pyridine-3-Carboxylate ethyl1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxohydropyridino[2,3-b]pyridine-3-c ETHYL 7-CHLORO-1-(2,4-DIFLUOROPHENYL)-6-FLUORO-1,4-DIHYDRO-4-OXONAPHTHYRIDINE-3-CARBOXYLATE 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester Ethyl 1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxopyridino[2,3-b]pyridine-3-carboxylate 7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Ethyl Ester 7-Chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester 95+% Ethyl 1-(2,4-difluorophenyl)-7-Cl-6-F-4-O-hydropyridino[2,3-b]pyridine-3-carboxylate, 99% 5GR 1,8-Naphthyridine-3-carboxylic acid 7-chloro-1- (2,4- difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-, ethyl ester -6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate Ethyl 7-chloro-1-(2,4-difluorophenyl) 1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4 -oxopyridino[2,3-b]pyridine-3-carboxylate Tosufloxacin Impurity 2 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE ethyl1-(2,4-difluorophenyl)-7-chloro-6-fluoro-4-oxohydropyridino ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE ISO 9001：2015 REACH ETHYL 1-(2 4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2 3-B] PYRIDINE-3-CARBOXYLATE ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYR... 100491-29-0 ETHYL 1-(2,4-DIFLUOROPHENYL)-7-CHORO-6-FLUORO-4-OXO-HYDROPYRIDINO[2,3-B] PYRIDINE-3-CARBOXYLATE Ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate RRR-α-Tocopherolum Ethyl 7-Chloro-6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate Tosufloxacin Impurity Ethyl 1-(2,4-difluorophenyl)-7-choro-6-fluoro-4-oxo-hydropyridino[2,3-b] pyridine-3-carboxylate 100491-29-0 C17H10ClF3N2O3 Intermediates & Fine Chemicals Pharmaceuticals Heterocycles Intermediates