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Seocalcitol

Seocalcitol Structure
Seocalcitol structure
CAS No.
134404-52-7
Chemical Name:
Seocalcitol
Synonyms
Seocalcitol;Theocalcitriol;(1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R,3E,5E)-7-Ethyl-7-hydroxynona-3,5-dien-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol;(1R,3S,5Z)-5-((2E)-((1R,3aS,7aR)-1-((1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol;1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-;EB 1089,(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol
CBNumber:
CB61179727
Molecular Formula:
C30H46O3
Molecular Weight:
454.68
MDL Number:
MFCD00871599
MOL File:
134404-52-7.mol
Last updated:2025-08-21 22:16:43
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Seocalcitol Properties

Melting point 123-125°
Boiling point 608.5±55.0 °C(Predicted)
Density 1.06±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form solid
pka 14.29±0.29(Predicted)
color White
NCI Dictionary of Cancer Terms seocalcitol
FDA UNII Q0OZ0D9223
UNSPSC Code 12352200
NACRES NA.77

Seocalcitol price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1727 EB1089 ≥98% (HPLC) 134404-52-7 1 mg $240 2025-07-31 Buy
Cayman Chemical 21579 EB 1089 ≥98% 134404-52-7 500μg $97 2024-03-01 Buy
Cayman Chemical 21579 EB 1089 ≥98% 134404-52-7 1mg $184 2024-03-01 Buy
Cayman Chemical 21579 EB 1089 ≥98% 134404-52-7 5mg $773 2024-03-01 Buy
TRC E320200 EB1089 134404-52-7 10mg $1105 2021-12-16 Buy
Product number Packaging Price Buy
SML1727 1 mg $240 Buy
21579 500μg $97 Buy
21579 1mg $184 Buy
21579 5mg $773 Buy
E320200 10mg $1105 Buy

Seocalcitol Chemical Properties,Uses,Production

Description

EB 1089 is a synthetic vitamin D analog that is 50-200 times more potent than calcitriol at inhibiting cell proliferation and differentiation, yet displays reduced calcemic activity compared to that of calcitriol. It has been shown to promote tumor regression in vitro by inducing apoptosis.

Uses

EB 1089 is an analogue of Calcitriol (C144500), which is a biologically active form of Vitamin D3 (1). It can be used in androgen receptor-targeted therapy research for breast cancer (2). EB 1089 exhibits anti-cancer properties.

in vivo

Seocalcitol (EB1089), a synthetic vitamin D analog, exhibits reduced hypercalcemic activity relative to 1,25(OH)2VD3. In another study, long-term intraperitoneal (IP) administration of Seocalcitol at a dose of 0.5 μg/kg body weight every other day in C3H/Sy mice exertes a very strong inhibitory effect on hepatocellular carcinoma (HCC) development[4]. Seocalcitol (EB 1089) is administered daily to postnatal rats from 4 to 12 days of age (P4 to P12) by intraperitoneal injection at either 0.38 or 1.25 μg/kg body weight (BW)/day. Only the highest dose of Seocalcitol (1.25 μg/kg BW) causes a significant reduction in weight gain when administered alone or in conjunction with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid[5].

References

[1] C M HANSEN. Seocalcitol (EB 1089): a vitamin D analogue of anti-cancer potential. Background, design, synthesis, pre-clinical and clinical evaluation.[J]. Current pharmaceutical design, 2000, 6 7: 803-828. DOI: 10.2174/1381612003400371
[2] S Y JAMES. EB1089, a synthetic analogue of vitamin D, induces apoptosis in breast cancer cells in vivo and in vitro.[J]. British Journal of Pharmacology, 1998, 125 5: 953-962. DOI: 10.1038/sj.bjp.0702103

Seocalcitol Preparation Products And Raw materials

Raw materials

Preparation Products

Seocalcitol Suppliers

Global( 102)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29734 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 13090 58
Nanjing Dolon Biotechnology Co.,Ltd. 		18905173768 52513593@qq.com CHINA 2972 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29800 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32432 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
CR Corporation Limited 		+8613062833949 fred.wen@crcorporation.cn China 8647 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Nanjing Dolon Biotechnology Co.,Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
CR Corporation Limited 		58

View Lastest Price from Seocalcitol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Seocalcitol pictures 2025-08-21 Seocalcitol
134404-52-7
 US $2790.00-667.00 / mg 10g TargetMol Chemicals Inc.
Seocalcitol pictures 2025-08-21 Seocalcitol
134404-52-7
 US $0.00-0.00 / g 10g 99.0%min. HPLC 10000 HangZhou RunYan Pharma Technology Co.,LTD.
Seocalcitol pictures 2020-02-14 Seocalcitol
134404-52-7
 US $7.00 / KG 1KG 99% 100kg Career Henan Chemical Co
  • Seocalcitol pictures
  • Seocalcitol
    134404-52-7
  • US $2790.00-667.00 / mg
  • TargetMol Chemicals Inc.
  • Seocalcitol pictures
  • Seocalcitol
    134404-52-7
  • US $0.00-0.00 / g
  • 99.0%min. HPLC
  • HangZhou RunYan Pharma Technology Co.,LTD.
  • Seocalcitol pictures
  • Seocalcitol
    134404-52-7
  • US $7.00 / KG
  • 99%
  • Career Henan Chemical Co

134404-52-7(Seocalcitol)Related Search:

Vitamin D3 (5R)-ethyl 5-((1R,3aS,7aR)-4-((E)-2-((3S,5R)-3,5-bis(tert-butyldiMethylsilyloxy)-2-Methylenecyclohexylidene)ethyl)-7a-Methyloctahydro-1H-inden-1-yl)hexanoate FALECALCITRIOL N,5-bis(4-chlorophenyl)-3-iMino-3,5-dihydrophenazin-2-aMine 5-(4-{2-[5-(tert-Butyl-dimethyl-silanyloxy)-2-methylene-cyclohexylidene]-ethylidene}-7a-methyl-octahydro-inden-1-yl)-hexanoic acid ethyl ester
methylene calcitriol Paricalcitol Alfacalcidol ELOCALCITOL INECALCITOL
Lexacalcitol Seocalcitol

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(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol Seocalcitol (1R,3S,5Z)-5-((2E)-((1R,3aS,7aR)-1-((1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol EB 1089,(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-Ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]-octahydro-7α-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-1,3-cyclohexanediol 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)- (1R,3S,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R,3E,5E)-7-Ethyl-7-hydroxynona-3,5-dien-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol Theocalcitriol 134404-52-7