Potassium 3-methoxy-3-oxopropanoate
- CAS No.
- 38330-80-2
- Chemical Name:
- Potassium 3-methoxy-3-oxopropanoate
- Synonyms
- METHYL POTASSIUM MALONATE;MONOMETHYL MONOPOTASSIUM MALONATE;POTASSIUM MONOMETHYL MALONATE;POTASSIUM METHYL MALONATE;Monomethyl Potassium Malonate;MONO-METHYL MALONATE POTASSIUM SALT;KMM;Potassium 3-methoxy-;Potassiummonomethylmallonate;Methyl potassium malonate 98%
- CBNumber:
- CB6123891
- Molecular Formula:
- C4H5KO4
- Molecular Weight:
- 156.18
- MDL Number:
- MFCD00014021
- MOL File:
- 38330-80-2.mol
- MSDS File:
- SDS
| Melting point | 200 °C |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in methanol. |
| form | Crystalline Powder |
| color | White |
| PH | pH(50g/l, 25℃) : 5.5～8.0 |
| BRN | 3633585 |
| InChI | InChI=1S/C4H6O4.K/c1-8-4(7)2-3(5)6;/h2H2,1H3,(H,5,6);/q;+1/p-1 |
| InChIKey | WWTULTKUWBKVGV-UHFFFAOYSA-M |
| SMILES | C(=O)(OC)CC([O-])=O.[K+] |
| CAS DataBase Reference | 38330-80-2(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H304 | |||||||||
| Precautionary statements | P501-P331-P301+P310-P405 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3 | |||||||||
| HS Code | 29171910 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Potassium 3-methoxy-3-oxopropanoate price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 63405 | Methyl potassium malonate ≥99.0% (NT) | 38330-80-2 | 50g | $191 | 2026-04-30 | Buy |
| Sigma-Aldrich | 63405 | Methyl potassium malonate ≥99.0% (NT) | 38330-80-2 | 250g | $217 | 2026-04-30 | Buy |
| TCI Chemical | M2149 | Monomethyl Potassium Malonate >98.0%(T) | 38330-80-2 | 25g | $42 | 2026-04-30 | Buy |
| TCI Chemical | M2149 | Monomethyl Potassium Malonate >98.0%(T) | 38330-80-2 | 250g | $241 | 2026-04-30 | Buy |
| Usbiological | 278997 | Hydrogen methyl malonate potassium salt | 38330-80-2 | 50g | $342 | 2026-06-03 | Buy |
Potassium 3-methoxy-3-oxopropanoate Chemical Properties, Uses, Production
Chemical Properties
White crystalline powder
Uses
Methyl potassium malonate is a protein advanced glycosylation inhibitor.
Uses
Methyl potassium malonate can be used in the total synthesis of (±)-vincorine, an akuammiline alkaloid which can find applications in biology. It can also be used to synthesize a key keto proline ester intermediate to prepare acutumine.
Synthesis
108-59-8
38330-80-2
The general procedure for the synthesis of monomethyl malonate potassium salt from dimethyl malonate was as follows: referring to the literature method, dimethyl malonate (40.0 mmol), water (40.0 mmol), and ethanol (45 mL) were added to a 250 mL two-necked round-bottomed flask, and the mixture was stirred and mixed. The mixture was reacted in an oil bath at 40°C for 2 hours. Subsequently, a solution of potassium tert-butoxide (40.0 mmol) in ethanol (45 mL) was slowly added dropwise over 30 minutes. After the dropwise addition, the reaction was continued with stirring in a 40°C oil bath until the feedstock was completely consumed (the progress of the reaction was monitored by GC analysis). Upon completion of the reaction, the ethanol solvent was slowly evaporated using a rotary evaporator, followed by the addition of 20 mL of diethyl ether. The resulting solid product was collected by filtration and washed sequentially with a 1:1 mixture of ether and ethanol (5 mL × 2) and pure ether (10 mL × 3). The washed solid was transferred to a round-bottomed flask and dried under vacuum at 50 °C for 10 h. The final potassium salt of monomethyl malonate was obtained in 85% yield.
References
[1] Tetrahedron, 2012, vol. 68, # 9, p. 2113 - 2120
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 19, p. 4470 - 4474
[3] Patent: CN106467492, 2017, A. Location in patent: Paragraph 0129; 0130; 0131
[4] Journal of Physical Chemistry, 1987, vol. 91, # 19, p. 5129 - 5134
[5] Patent: US6172257, 2001, B2
Potassium 3-methoxy-3-oxopropanoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Weifang Mingran Chemical Co., Ltd. | QQ117761326 QQ2829453795 15063661899; | mingranchem@163.com | China | 493 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| MedicalChem(Yancheng)Manuf.Co.,Ltd | +86-515-84383180 | sales@medicalchem.com | China | 80 | 69 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Ark Pharm, Inc. | 847-367-3680 | sales@arkpharminc.com | United States | 1669 | 56 |
| Beijing dtftchem Technology Co., Ltd. | 010-60275820 13031183356 | elainezt@sina.com | China | 1386 | 62 |
View Latest Price from Potassium 3-methoxy-3-oxopropanoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | Potassium 3-methoxy-3-oxopropanoate
38330-80-2
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-04-20 | Methyl potassium malonate
38330-80-2
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-03-20 | Potassium 3-methoxy-3-oxopropanoate
38330-80-2
|
$9.90 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd |
-
- Potassium 3-methoxy-3-oxopropanoate
38330-80-2
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Methyl potassium malonate
38330-80-2
- $1520.00-2500.00
- TargetMol Chemicals Inc.
-
- Potassium 3-methoxy-3-oxopropanoate
38330-80-2
- $9.90
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
