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FMOC-D-Valine

FMOC-D-Valine structure

CAS No.: 84624-17-9

Chemical Name:: FMOC-D-Valine

Synonyms: FMOC-D-VAL-OH;FMOC-D-VAL;(R)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-Methylbutanoic acid;N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-D-VALINE;FMOC-D-VALINE;FMco-D-Val-OH;N-FMOC-D-VALINE;FMOC-D-VALINE 98%;(R)-N-Fmoc-valine;Fmoc-D-Val-OH,98%

CBNumber:: CB6133511

Molecular Formula:: C20H21NO4

Molecular Weight:: 339.39

MDL Number:: MFCD00062953

MOL File:: 84624-17-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-13 19:59:05

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FMOC-D-Valine Properties

Melting point	143-144 °C(lit.)
alpha	17 º (c=1, DMF)
Boiling point	551.8±33.0 °C(Predicted)
Density	1.229±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMF (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	3.90±0.10(Predicted)
color	White
optical activity	Consistent with structure
Water Solubility	Solubility in methanol (almost transparency). Slightly soluble in water.
BRN	6489548
Major Application	peptide synthesis
InChI	1S/C20H21NO4/c1-12(2)18(19(22)23)21-20(24)25-11-17-15-9-5-3-7-13(15)14-8-4-6-10-16(14)17/h3-10,12,17-18H,11H2,1-2H3,(H,21,24)(H,22,23)/t18-/m1/s1
InChIKey	UGNIYGNGCNXHTR-GOSISDBHSA-N
SMILES	CC(C)[C@@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(O)=O
CAS DataBase Reference	84624-17-9(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335-H319

Precautionary statements

P271-P261-P280-P403+P233

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

22-24/25

WGK Germany

HS Code

2924 29 70

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

FMOC-D-Valine price More Price(91)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52152	Fmoc-D-Val-OH Novabiochem?	84624-17-9	5G	$110	2026-04-30	Buy
Sigma-Aldrich	8.52152	Fmoc-D-Val-OH Novabiochem?	84624-17-9	25g	$443	2026-04-30	Buy
Sigma-Aldrich	8.52152	Fmoc-D-Val-OH Novabiochem^®	84624-17-9	100 g	$1070	2026-04-30	Buy
Sigma-Aldrich	8.52152	Fmoc-D-Val-OH Novabiochem^®	84624-17-9	1 kg	$3590	2026-04-30	Buy
Sigma-Aldrich	47481	Fmoc-D-Val-OH ≥98.0% (HPLC)	84624-17-9	5g	$81.5	2025-07-31	Buy

Product number	Packaging	Price	Buy
8.52152	5G	$110	Buy
8.52152	25g	$443	Buy
8.52152	100 g	$1070	Buy
8.52152	1 kg	$3590	Buy
47481	5g	$81.5	Buy

FMOC-D-Valine Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

N-Fmoc-D-valine is an N-Fmoc-protected form of D-Valine (V094200). D-Valine (an isomer of the essential amino acid L-Valine [V094205])exhibited inhibitory effects on fibroblasts that contaminated mammalian kidney cultures, allowing for selective growth epithelial cells. D-Valine is also known for its presence in the structure of Actinomycin D, an antitumour drug. D-Valine is naturally synthesized by Streptomyces antibioticus.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

640-68-6

28920-43-6

84624-17-9

General procedure for the synthesis of Fmoc-D-valine from D-valine and chloroformic acid-9-fluorenylmethyl ester: A 500 mL three-necked flask was taken, and D-valine (4.5 g, 38.9 mmol), dioxane (40 mL), and 10% aqueous sodium carbonate (100 mL) were added sequentially. The reaction system was placed in an ice bath and mechanical stirring was initiated. A dioxane solution (100 mL) of methyl chloroformate-9-fluorenyl (10.0 g, 38.8 mmol) was prepared in a dropping funnel and slowly added dropwise to the reaction vial. After the dropwise addition was completed, it was gradually brought to room temperature and stirring was continued overnight. After completion of the reaction, 100 mL of water was added to the reaction mixture and extracted three times with 50 mL of ether and the organic phase was discarded. The aqueous phase was cooled in an ice bath, and the pH was adjusted to 1 by slowly adding 1 M dilute hydrochloric acid, followed by extracting the aqueous phase with 50 mL ethyl acetate three times, combining the organic phases and drying with anhydrous magnesium sulfate. The desiccant was removed by filtration and the organic phase was concentrated under reduced pressure to give the white solid product Fmoc-D-valine (12.6 g, 96% yield).

References

[1] Patent: CN106588987, 2017, A. Location in patent: Paragraph 0172; 0173; 0174
[2] Chemistry - A European Journal, 2014, vol. 20, # 21, p. 6526 - 6531

FMOC-D-Valine Preparation Products And Raw materials

Raw materials

D-Valine 9-Fluorenylmethyl chloroformate 1,4-Dioxane Sodium carbonate

Preparation Products

FMOC-D-Valine Suppliers

Global Suppliers ( 377)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64

View Latest Price from FMOC-D-Valine manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-15	Fmoc-D-Val-OH 84624-17-9	1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-09-11	FMOC-D-Valine 84624-17-9	1KG	98.0%	500kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-07-13	FMOC-D-Valine 84624-17-9	1KG	98%	1000kgs	Shaanxi Dideu New Materials Co. Ltd

Fmoc-D-Val-OH
84624-17-9
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

FMOC-D-Valine
84624-17-9
$0.00
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

FMOC-D-Valine
84624-17-9
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

FMOC-D-Valine Spectrum

FMOC-D-Valine(84624-17-9)¹HNMR

84624-17-9 (FMOC-D-Valine) Related Search:

Fmoc-OSu Fmoc-D-glutamic acid gamma-tert-butyl ester Fmoc-Lys(Boc)-OH Fmoc-D-Ile-OH Valine

Fmoc-Aib-OH L-Valine Fmoc-Asp(OtBu)-OH 9-Fluorenylmethyl chloroformate D-Valine

Fmoc-Phe-OH 1,1'-Carbonyldiimidazole L-Fmoc-Aspartic acid alpha-tert-butyl ester Glycine FMOC-L-Valine

Fmoc Carbonyl iron powder Nickel carbonyl

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Fmoc-D-Val-OH >=98.0% (HPLC) Fmoc-D-valine≥ 99% (HPLC) N-FMOC-D-VALINE 2-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-3-methylbutanoic acid (R)-2-(Fmoc-amino)-3-methylbutyric Acid (2R)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methylbutanoic acid N-9-FLUORENYLMETHYLOXYCARBONYL-D-VALINE N-(9-FLUORENYLMETHOXYCARBONYL)-D-VALINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-D-VALINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-D-VALINE N-ALPHA-FMOC-D-VALINE FMOC-D-VALINE 9-FLUORENYLMETHOXYCARBONYL-D-VALINE FMOC-D-VALINE 98% FLUORENYLMETHOXYCARBONYL-D-VALINE(FMOC-D-VAL-OH) FMOC-D-VALINE extrapure N-(9-Fluorenylmethoxycarbonyl)-D-valine, Fmoc-D-valine Nα-(9-Fluorenylmethyloxycarbonyl)-D-valine ,99% 2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-methylbutanoic acid Fmoc-D-valine ,99% FMco-D-Val-OH N-Fmoc-D-valine Fmoc-D-Val-OH (9H-Fluoren-9-yl)MethOxy]Carbonyl D-Val-OH FMoc-D-Val-OH ,99% N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-valine> D-Valine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- FMOC-D-Valine USP/EP/BP (R)-N-Fmoc-valine Fmoc-D-Val-OH,98% Valine Impurity 2 (Fmoc-D-Val-OH) Ensitrelvir Impurity 39 Fmoc-D-Val-OH N-(9-fluorene methoxycarbonyl)- D-valine Fmoc-D-Val-OH 98% D-Valine, N-FMOC protected ((((9H-fluoren-9-yl)methoxy)carbonyl)-D-valyl)oxonium (R)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-Methylbutanoic acid FMOC-D-VAL-OH FMOC-D-VAL N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-D-VALINE 84624-17-9 4624-17-9 Valine Peptide Synthesis Specialty Synthesis Amino Acid Derivatives Valine [Val, V] Fmoc-Amino Acids and Derivatives Amino Acids (N-Protected) Biochemistry Fmoc-Amino Acids Fmoc-Amino acid series Fluorenes, Flurenones Amino Acid Derivatives Amino Acids